Meiosis appears to be unaffected in eggs derived from fzy6/fzy7 females raised at the permissive temperature of 22oC.
Eggs derived from fzy6/fzy7 females raised at the restrictive temperature of 29oC have defects in meiosis. 74% of these eggs contain two spindles near the cortex, indicative of a delay or arrest in meiosis II. In most cases, both spindles have two X-chromosome signals, indicating arrest in anaphase of meiosis II. The two X-chromosomes are often not aligned properly along the spindle axis, probably as a result of prolonged arrest. In rare cases, more than two X-chromosome signals per spindle are seen. One or more small spindles with associated chromatin are often seen near the two major spindles. 13% of embryos contain one or more spindles at the anterior cortex in addition to a polar body, suggesting partial completion of meiosis and only 6% of embryos appear to have completed meiosis. 8% of the eggs contain only a single spindle near the cortex, possibly indicating a meiosis I arrest.
Embryos derived from fzy6/fzy7 females do not develop beyond the 2nd or 3rd nuclear division and their nuclei arrest at the metaphase-anaphase transition (FBrf0058082). These nuclei often contain an excess of microtubules in their spindles, and astral microtubules are often missing.
At 25oC it is a pharate adult lethal, with macrochaetae and abdominal cuticle missing. At 18oC homozygotes are viable but female sterile, with normal eggs but embryos that fail to develop.