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General Information
Symbol
Dmel\pebhnt-E8
Species
D. melanogaster
Name
FlyBase ID
FBal0031497
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hntE8
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The posterior half of the abdomen is folded back on the anterior half, due to a failure of germband retraction, resulting in an eponymous phenotype. At full germband extension A8 is often opposite A2. Head involution fails. Some components of the head skeleton are absent or rudimentary, including the dorsal arms, dorsal bridge and vertical plate. The filzkorper are often separated, though less so than for ush mutants. An anterior dorsal hole is also sometimes evident. peb mutants often show a head-back phenotype. Anti-β-tubulin staining reveals a premature loss of amnioserosa cells after stage 11. The amnioserosa undergoes programmed cell death.

    Within constraints of the embryo being folded due to the hnt mutation, the muscle pattern is normal and movement is vigorous and well coordinated.

    Longitudinal tracts are interrupted. Intersegmental gaps show in glial scaffold and in the midline, the glial scaffold retracts after initial extension, though the longitudinal glial morphogenesis is abnormal.

    Suppression of tor13D embryos: increase in proportion of embryos that formed cuticle with denticles and decrease in proportion of embryos that formed empty sacs.

    External Data
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    Xenogenetic Interactions
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    Complementation and Rescue Data
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    Images (0)
    Mutant
    Wild-type
    Stocks (2)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (9)