FlyBase Allele Report: Dmel\chic[221]

General Information

Symbol

Dmel\chic²²¹

Species

D. melanogaster

Name

FlyBase ID

FBal0034343

Feature type

allele

Associated gene

Dmel\chic

Associated Insertion(s)

Carried in Construct

Also Known As

chickadee²²¹

Genomic Maps

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Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Johnson et al., 2008, Manseau et al., 1996, Doberstein et al., 1995, Verheyen and Cooley, 1994)

Mutagen

Delta2-3 transposase

(Verheyen and Cooley, 1994)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

deletion

2L:5,975,585..5,980,992 [-]

Linked to:

SalI-EcoRI restriction fragment

Comment:

The rough boundaries of the P excision mutation were mapped to a restriction fragment. The deletion takes out 5' noncoding and some coding sequence of chic. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator

(Verheyen and Cooley, 1994)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

chic⁰⁷⁸⁸⁶

(Verheyen and Cooley, 1994)

Cytology

Nature of the lesion

Statement

Reference

Deletion of 5' non-coding and some of coding region of chic.

(Verheyen and Cooley, 1994)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

actin filament & eye disc | somatic clone

(Benlali et al., 2000)

border follicle cell

(Verheyen and Cooley, 1994)

border follicle cell (with chic⁰¹³²⁰)

(Geisbrecht and Montell, 2004)

crossvein | ectopic

(Doberstein et al., 1995)

embryonic/first instar larval cuticle | dorsal

(Jasper et al., 2001)

embryonic/larval anterior midgut | embryonic stage 15

(Okumura et al., 2010)

embryonic/larval anterior midgut | embryonic stage 16

(Okumura et al., 2010)

embryonic/larval anterior midgut | embryonic stage 17

(Okumura et al., 2010)

embryonic/larval salivary gland

(Maybeck and Röper, 2009)

embryonic dorsal epidermis

(Jasper et al., 2001)

embryonic leading edge cell

(Jasper et al., 2001)

embryonic proventriculus | embryonic stage 15

(Okumura et al., 2010)

embryonic proventriculus | embryonic stage 16

(Okumura et al., 2010)

embryonic proventriculus | embryonic stage 17

(Okumura et al., 2010)

embryonic somatic muscle

(Kim et al., 2001)

filopodium (with chic^05205a)

(Gonçalves-Pimentel et al., 2011)

filopodium (with Df(2L)Gpdh1-A)

(Gonçalves-Pimentel et al., 2011)

germinal proliferation center hub (with chic⁰¹³²⁰)

(Shields et al., 2014)

intersegmental nerve

(Kim et al., 2001)

longitudinal connective

(Kim et al., 2001)

longitudinal connective (with chic^05205a)

(Wills et al., 1999)

male germline stem cell (with chic⁰¹³²⁰)

(Shields et al., 2014)

morphogenetic furrow | somatic clone

(Benlali et al., 2000)

motor neuron (with Df(2L)Gpdh1-A)

(Gonçalves-Pimentel et al., 2011)

nurse cell

(Verheyen and Cooley, 1994)

oocyte | oogenesis stage S8

(Manseau et al., 1996)

oocyte | oogenesis stage S9 (with chic⁰¹³²⁰)

(Dahlgaard et al., 2007)

photoreceptor cell & eye disc | somatic clone

(Benlali et al., 2000)

spermatocyte (with chic⁰¹³²⁰)

(Shields et al., 2014)

spermatogonium (with chic⁰¹³²⁰)

(Shields et al., 2014)

testis (with chic⁰¹³²⁰)

(Shields et al., 2014)

wing

(Doberstein et al., 1995)

Detailed Description

Statement

Reference

Germline stem cell number is significantly reduced in chic²²¹/chic⁰¹³²⁰ larval testes compared to controls. In contrast to wild type testes, elongated spermatid bundles are located close to the apical tip in newly eclosed flies. Spermatogonia and spermatocytes are rare or not detected.

chic²²¹ mutant germline stem cell (GSC) clones are seen next to the hub in the testes at 3 days post clone induction, but this number decreases over time; in contrast to wild type clones, by 11 days post clone induction no chic²²¹ mutant GSCs are seen. chic²²¹ mutant GSCs are able to differentiate and progress to spermatocytes, but chic²²¹ mutant spermatid clones are observed, suggesting that the clones are unable to complete terminal differentiation.

(Shields et al., 2014)

Mean filopodium length is reduced compared to wild type in cultured primary neurons derived from chic²²¹/chic^05205a embryos.

Cultured primary neurons derived from chic²²¹/Df(2L)GpdhA embryos show a significant increase in the number of filopodia compared to control neurons. The mean length of the filopodia is reduced in the mutant neurons compared to controls.

chic²²¹/Df(2L)GpdhA embryos show stalling of motor axons compared to wild type.

(Gonçalves-Pimentel et al., 2011)

chic²²¹ homozygous stage 16 embryos show laterality defects in the proventriculus and anterior midgut. The laterality of the other parts of the embryonic gut, including the hindgut and the posterior part of the midgut is normal in these mutants. The proventriculus and the anterior midgut do not rotate (as in wild-type) in these mutants at stages 15 to 17.

(Okumura et al., 2010)

At a stage when the first cells have just invaginated from the salivary gland placode, cell shapes within mutant placodes often appear irregular compared to wild type. At later stages, the salivary glands invaginate but are irregular in shape, and the placodal and surrounding epidermal cells on the surface of the embryos appear disrupted.

(Maybeck and Röper, 2009)

Homozygous chic²²¹ mutants exhibit CNS defects in less than 10% of embryos.

(Matusek et al., 2008)

Stage 9 chic⁰¹³²⁰/chic²²¹ oocytes show premature cytoplasmic streaming.

(Dahlgaard et al., 2007)

Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for chic²²¹ do not show defects in the establishment or maintenance of dendritic tiling.

(Parrish et al., 2007)

chic²²¹ embryos show normal salivary glands.

(Chandrasekaran and Beckendorf, 2005)

16% of chic⁰¹³²⁰/chic²²¹ egg chambers have border follicle cell migration defects.

(Geisbrecht and Montell, 2004)

chic²²¹ homozygotes have thin cuticles, and approximately 30% of cuticle preps have dorsal holes, indicating varying degrees of dorsal closure defects. At stage 14-15 these embryos show incomplete cell stretching and misalignment of the two lateral epidermal cell sheets during dorsal closure. The prominent actin cable seen in leading edge cells at this stage in wild-type embryos is much reduced in chic²²¹ homozygotes.

(Jasper et al., 2001)

Mutant embryos show defects in motor axon extension, including the ISNb and ISN branches.

Homozygous embryos have slightly disorganised longitudinal connectives, although some have small gaps in the longitudinal connectives.

Mutant embryos have significant defects in muscle formation.

(Kim et al., 2001)

Homozygous clones in the eye disc cause a reduction in actin polymerisation. Homozygous clones that overlap the morphogenetic furrow disrupt the timing of photoreceptor differentiation. Large clones in the eye disc show a disorganisation and reduction of photoreceptor differentiation. Mutant cells in the region of the morphogenetic furrow do not undergo the normal shape changes and instead retain large apical profiles. Apical constriction of cells at the lateral edges of mutant clones in the eye disc is seen.

(Benlali et al., 2000)

Heterozygous flies have no structural brain abnormalities.

(Boquet et al., 2000)

Lethal in combination with chic^sand-1 or chic^sand-2. chic^05205a/chic²²¹ embryos show mild defects in the Fas2-positive longitudinal fascicles of the central nervous system.

(Wills et al., 1999)

Microtubules are bundled to the cortex of stage 8 egg chambers. Premature cytoplasmic streaming occurs in stage 8 egg chambers. Microtubule phenotype more closely resembles that of capu mutants than does that of the weaker chic⁰¹³²⁰ allele.

(Manseau et al., 1996)

Semilethal in combination with chic^gdh-5. 71% escapers have ectopic wing crossveins, held up wings and are male sterile.

(Doberstein et al., 1995)

The egg chambers of chic⁰¹³²⁰/chic²²¹ and chic⁰¹³²⁰/Df(2L)GpdhA females usually have too few nurse cells that are mostly binucleate. The variation in nurse cell number is great, with some chambers having as many as 30. 10% of egg chambers show a failure of border cell migration.

(Verheyen and Cooley, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

chic²²¹ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Khc::Ggal\MLCK^KA.ftz

(Kim et al., 2001)

NOT suppressed by

Statement

Reference

chic⁰¹³²⁰/chic²²¹ has decreased cell number phenotype, non-suppressible by Scer\GAL4^VP16.nos.UTR/Apc2^UAS.GFP

(Shields et al., 2014)

Enhancer of

Statement

Reference

chic[+]/chic²²¹ is an enhancer of abnormal axis specification | embryonic stage 16 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of abnormal axis specification | embryonic stage 15 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of abnormal axis specification | embryonic stage 17 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

(Johnson et al., 2008)

chic[+]/chic²²¹ is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex68

(Matusek et al., 2008)

chic[+]/chic²²¹ is an enhancer of lethal | embryonic stage | partially | recessive phenotype of peb³⁰⁸

(Wilk et al., 2004)

NOT Enhancer of

Statement

Reference

chic[+]/chic²²¹ is a non-enhancer of abnormal neuroanatomy phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}

(Matusek et al., 2008)

Suppressor of

Statement

Reference

chic[+]/chic²²¹ is a suppressor | partially of visible phenotype of twf¹¹⁰

(Wang et al., 2010)

chic²²¹ is a suppressor of abnormal neuroanatomy phenotype of Hsap\APP^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

chic[+]/chic²²¹ is a suppressor of abnormal neuroanatomy phenotype of Fmr1^Δ113M

(Reeve et al., 2005)

chic[+]/chic²²¹ is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

chic[+]/chic²²¹ is a suppressor | partially of abnormal developmental rate phenotype of cpb^F19/cpb^6.15

(Hopmann and Miller, 2003)

chic[+]/chic²²¹ is a suppressor | partially of partially lethal - majority die phenotype of cpb^F19/cpb^6.15

(Hopmann and Miller, 2003)

Other

Statement

Reference

Csk^GD9345, Scer\GAL4^ptc-559.1, chic[+]/chic²²¹ has abnormal cell migration phenotype

(Rudrapatna et al., 2014)

Csk^GD9345, chic²²¹ has lethal phenotype

(Rudrapatna et al., 2014)

chic[+]/chic²²¹, cib^P has sterile phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has visible phenotype

(Boquet et al., 2000)

chic²²¹, cib^P has sterile phenotype

(Boquet et al., 2000)

chic²²¹, cib^P has visible phenotype

(Boquet et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

chic⁰¹³²⁰/chic²²¹ has border follicle cell phenotype, enhanceable by Diap1^21-2s/th[+]

(Geisbrecht and Montell, 2004)

chic⁰¹³²⁰/chic²²¹ has border follicle cell phenotype, enhanceable by Diap1⁵/th[+]

(Geisbrecht and Montell, 2004)

chic²²¹ has intersegmental nerve phenotype, enhanceable by Khc::Ggal\MLCK^KA.ftz

(Kim et al., 2001)

chic^05205a/chic²²¹ has longitudinal connective phenotype, enhanceable by Abl²/Abl[+]

(Wills et al., 1999)

chic^05205a/chic²²¹ has longitudinal connective phenotype, enhanceable by Abl²/Abl⁴

(Wills et al., 1999)

NOT suppressed by

Statement

Reference

chic⁰¹³²⁰/chic²²¹ has male germline stem cell phenotype, non-suppressible by Scer\GAL4^VP16.nos.UTR/Apc2^UAS.GFP

(Shields et al., 2014)

chic⁰¹³²⁰/chic²²¹ has male germline stem cell phenotype, non-suppressible by Scer\GAL4^VP16.nos.UTR/shg^UAS.sgGFP

(Shields et al., 2014)

chic⁰¹³²⁰/chic²²¹ has oocyte | oogenesis stage S9 phenotype, non-suppressible by Scer\GAL4^VP16.nos.UTR/capu^ΔN.UASp.GFP

(Dahlgaard et al., 2007)

Enhancer of

Statement

Reference

chic[+]/chic²²¹ is an enhancer of embryonic/larval anterior midgut | embryonic stage 16 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of embryonic/larval anterior midgut | embryonic stage 15 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of embryonic/larval anterior midgut | embryonic stage 17 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of embryonic proventriculus | embryonic stage 16 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of embryonic proventriculus | embryonic stage 15 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of embryonic proventriculus | embryonic stage 17 phenotype of zip³

(Okumura et al., 2010)

chic[+]/chic²²¹ is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

(Johnson et al., 2008)

chic[+]/chic²²¹ is an enhancer of pigment cell phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

(Johnson et al., 2008)

chic[+]/chic²²¹ is an enhancer of cone cell phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

(Johnson et al., 2008)

chic[+]/chic²²¹ is an enhancer of neuropil phenotype of DAAM^Ex68

(Matusek et al., 2008)

chic[+]/chic²²¹ is an enhancer of fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

chic[+]/chic²²¹ is an enhancer of connective phenotype of DAAM^Ex68

(Matusek et al., 2008)

chic[+]/chic²²¹ is an enhancer of lateral longitudinal fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

chic[+]/chic²²¹ is an enhancer of embryo phenotype of DAAM^Ex68

(Matusek et al., 2008)

chic²²¹ is an enhancer of actin cytoskeleton phenotype of Btk29A^k00206

(Chandrasekaran and Beckendorf, 2005)

chic²²¹ is an enhancer of presumptive embryonic salivary gland phenotype of Btk29A^k00206

(Chandrasekaran and Beckendorf, 2005)

chic[+]/chic²²¹ is an enhancer of embryonic/first instar larval cuticle | dorsal | rescuable maternal effect phenotype of hep¹

(Jasper et al., 2001)

chic[+]/chic²²¹ is an enhancer of ellipsoid body phenotype of cib^P

(Boquet et al., 2000)

NOT Enhancer of

Statement

Reference

chic[+]/chic²²¹ is a non-enhancer of neuropil | embryonic stage phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}, Scer\GAL4^elav-C155

(Matusek et al., 2008)

chic[+]/chic²²¹ is a non-enhancer of fascicle | embryonic stage phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}, Scer\GAL4^elav-C155

(Matusek et al., 2008)

chic[+]/chic²²¹ is a non-enhancer of commissure | embryonic stage phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}, Scer\GAL4^elav-C155

(Matusek et al., 2008)

Suppressor of

Statement

Reference

chic²²¹ is a suppressor of ventral adult lateral neuron & axon phenotype of Hsap\APP^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

chic[+]/chic²²¹ is a suppressor of LNv neuron phenotype of Fmr1^Δ113M

(Reeve et al., 2005)

chic[+]/chic²²¹ is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

chic[+]/chic²²¹ is a suppressor | partially of macrochaeta phenotype of cpb^F19/cpb^6.15

(Hopmann and Miller, 2003)

chic[+]/chic²²¹ is a suppressor | partially of trichogen cell & actin filament & pupa phenotype of cpb^F19/cpb^6.15

(Hopmann and Miller, 2003)

chic[+]/chic²²¹ is a suppressor | partially of embryonic/first instar larval cuticle phenotype of Scer\GAL4^arm.PS, hep^Act.UAS

(Jasper et al., 2001)

Other

Statement

Reference

Csk^GD9345, Scer\GAL4^ptc-559.1, chic[+]/chic²²¹ has wing disc phenotype

(Rudrapatna et al., 2014)

Df(3R)X3F/+, chic²²¹ has embryonic epidermis | embryonic stage 5 phenotype

(Zheng et al., 2013)

chic²²¹, ena²³/ena[+] has filopodium phenotype

(Gonçalves-Pimentel et al., 2011)

chic²²¹, cib^P has mushroom body medial lobe phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has adult thorax & chaeta phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has fan-shaped body phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has mushroom body medial lobe phenotype

(Boquet et al., 2000)

chic²²¹, cib^P has adult thorax & chaeta phenotype

(Boquet et al., 2000)

chic²²¹, cib^P has fan-shaped body phenotype

(Boquet et al., 2000)

Abl², chic^05205a/chic²²¹ has longitudinal connective phenotype

(Wills et al., 1999)

Abl⁴, chic^05205a/chic²²¹ has longitudinal connective phenotype

(Wills et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

A chic²²¹ heterozygous mutant background modifies the actin remodelling and subsequent basolateral invasion of epithelial cells seen in flies expressing Csk^GD9345 in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4^ptc-559.1.

(Rudrapatna et al., 2014)

Expression of Apc2^{Scer\UAS.T:Avic\GFP} in germ cells under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} does not suppress the germline stem cell (GSC) loss seen in chic²²¹/chic⁰¹³²⁰ mutant testes.

Expression of shg^{Scer\UAS.T:Avic\GFP-rs} in germ cells under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} does not suppress the germline stem cell (GSC) loss seen in chic²²¹/chic⁰¹³²⁰ mutant testes.

(Shields et al., 2014)

Unlike wild-type embryos or Df(3R)X3F heterozygotes, heterozygous chic²²¹ embryos in a Df(3R)X3F/+ genetic background display multi-nucleation during cellularization even at 18[o]C.

(Zheng et al., 2013)

Cultured primary neurons derived from Sop2¹/+ chic²²¹/+ and DAAM^Ex68/+ chic²²¹/+ double heterozygous embryos have a normal number of filopodia.

Cultured primary neurons derived from chic²²¹/+ ena²³/+ double heterozygous embryos show a significant reduction in the number of filopodia compared to control neurons.

(Gonçalves-Pimentel et al., 2011)

A chic²²¹ heterozygous background enhances the loss of rotation in the proventriculus and anterior midgut seen in zip³ homozygotes.

(Okumura et al., 2010)

chic²²¹/+ partially rescues the bristle phenotype of twf¹¹⁰ homozygous animals.

(Wang et al., 2010)

A chic²²¹ heterozygous background partially suppresses the rough eye phenotype seen in Fmr1^sev.PW mutants.

(Estes et al., 2008)

A chic²²¹ heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

(Johnson et al., 2008)

The Scer\GAL4^elav-C155/DAAM^{C.Scer\UAS.P\T} gain-of-function phenotype (i.e the appearance of thicker commissures and nerve roots) is not affected by a chic²²¹/+ background.

A chic²²¹ heterozygous background increases the proportion of DAAM^Ex68 mutant embryos that exhibit CNS defects.

(Matusek et al., 2008)

Expression of capu^{ΔN.Scer\UAS.P\T.T:Avic\GFP} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} does not suppress the premature cytoplasmic streaming seen in stage 9 chic⁰¹³²⁰/chic²²¹ oocytes.

(Dahlgaard et al., 2007)

The Btk29A^k00206 salivary gland phenotype is enhanced in chic²²¹, Btk29A^k00206 double mutants as more cells remain on the surface at stage 14 compared with Btk29A^k00206 single mutants. The amount of actin disorganization that precedes the salivary gland phenotype is also increased in these double mutants. Additionally, chic²²¹, Btk29A^k00206 double mutants exhibit a higher level of uncoordinated endoreplication at early stage 12, prior to the invagination defects, than Btk29A^k00206 single mutants.

(Chandrasekaran and Beckendorf, 2005)

The increased LNv dorso-ventral and medio-lateral extension phenotype is suppressed in Fmr1^Δ113M brains that also carry a chic²²¹/+ mutation.

(Reeve et al., 2005)

77% of chic⁰¹³²⁰/chic²²¹ ; th⁵/+ egg chambers have border follicle cell migration defects. 48% of chic⁰¹³²⁰/chic²²¹ ; th^21-2s/+ egg chambers have border follicle cell migration defects.

(Geisbrecht and Montell, 2004)

The abnormal midline crossing of axons seen in robo¹ heterozygotes is suppressed if the embryos are also heterozygous for chic²²¹.

(Kim et al., 2001)

Clones in the eye disc which are doubly mutant for capt^E636 and chic²²¹ show predominantly the chic²²¹ mutant phenotype.

(Benlali et al., 2000)

cib^P/+ ; chic²²¹/+ double heterozygotes show a cib-like mutant phenotype, with a partially split fan-shaped body (it is split along the midline in 10% of flies), a ventrally opened ellipsoid body and a normal mushroom body. This interaction is synergistic. Addition of chic²²¹ to cib^P/Y flies exacerbates the cib^P phenotype; cib^P/Y ; chic²²¹/+ males have a fan-shaped body that is split in the middle, a strongly disturbed ellipsoid body (it is flat and very often split along the midline) and disorganised mushroom body medial lobes that rarely reach their normal position. cib^P/Y ; chic²²¹/+ males are also sterile and show a thoracic bristle defect with shorter and forked ends than normal.

(Boquet et al., 2000)

The severity of the central nervous system defects of chic^05205a/chic²²¹ embryos is enhanced by Abl²/+ and further enhanced by Abl²/Abl⁴.

(Wills et al., 1999)

Xenogenetic Interactions

Statement

Reference

Heterozygosity for chic²¹¹ suppresses the Scer\GAL4^P2.4.Pdf>Hsap\APP^{Scer\UAS.T:Hsap\MYC}-induced increase in axonal arborization.

(Leyssen et al., 2005)

The frequency of motor neuron axon stalls seen in chic²²¹ embryos is increased by Khc::Ggal\MLCK^KA.ftz.

One copy of chic²²¹ suppresses the frequency of midline crossovers seen in Khc::Ggal\MLCK^KA.ftz embryos. However, Khc::Ggal\MLCK^KA.ftz chic²²¹ double mutant embryos show major defects in the formation of the central nervous system axon scaffold, with gaps or thinning of the longitudinal connectives, as axon bundles appear to preferentially cross the midline.

(Kim et al., 2001)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4892

chic²²¹ cn¹/CyO; ry⁵⁰⁶

Kyoto

107932