FB2025_01 , released February 20, 2025
Allele: Dmel\dsh75
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General Information
Symbol
Dmel\dsh75
Species
D. melanogaster
Name
FlyBase ID
FBal0034439
Feature type
allele
Associated gene
Dmel\dsh
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Park et al., 1996, Manoukian et al., 1995)

    loss of function allele

    (Neumann and Cohen, 1997)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        dsh75/+ flies display wild-type hair patterns on the wing, thorax and eyes.

        (Shami Shah et al., 2019)

        Homozygous clones in the wing result in ectopic bristles and notched wings.

        (Nakagoshi et al., 2002)

        Homozygous clones induced during the first larval instar show dramatic phenotypes in the dorsal wing hinge; dorsal hinge structures, with the exception of axillary sclerite 1, are obliterated if they fall within the clone. Homozygous clones in the proximal wing hinge result in duplication of the axillary pouch and the yellow club. The pleural wing process and pleural sclerite can also be missing.

        (Buratovich and Wilder, 2001)

        Embryos deficient for maternal and zygotic dsh show a dorsal-open phenotype.

        (McEwen et al., 2000)

        Embryos zygotically and maternally mutant for dsh75 show a complete absence of heart precursors. sggM11 dsh75 double mutant embryos have the same phenotype as sggM11 single mutant embryos.

        (Park et al., 1998)

        Homozygous clones in the anterior ventral region of the leg disc produce bifurcated or triplicated legs. Homozygous clones close to the proximal edge of the leg disc can produce a complete secondary leg. Clones located more distally can produce converging pattern triplications. Clones in the posterior compartment induce the formation of extra rows of mutant bristles. Clones in the dorsal third of the leg have no effect on pattern. sggM1-1 dsh75 double mutant clones behave like sggM1-1 single mutant clones.

        (Heslip et al., 1997)

        Embryos exhibit a lawn of denticle belts.

        (Manoukian et al., 1995)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Enhanced by
        Statement
        Reference

        dsh75 has phenotype, non-enhanceable by Apc2ΔS

        (McCartney et al., 1999)
        NOT suppressed by
        Statement
        Reference

        dsh75 has phenotype, non-suppressible by Apc2ΔS

        (McCartney et al., 1999)
        Other
        Statement
        Reference

        dsh75/dsh[+], kmr1 has wing hair phenotype

        (Shami Shah et al., 2019)

        dsh75/dsh[+], kmr1 has interommatidial bristle phenotype

        (Shami Shah et al., 2019)

        dsh75/dsh[+], kmr2 has notum phenotype

        (Shami Shah et al., 2019)

        dsh75/dsh[+], kmr1 has trichome phenotype

        (Shami Shah et al., 2019)

        dsh75/dsh[+], kmr1 has notum phenotype

        (Shami Shah et al., 2019)

        dsh75/dsh[+], kmr2 has wing hair phenotype

        (Shami Shah et al., 2019)

        dsh75/dsh[+], kmr2 has interommatidial bristle phenotype

        (Shami Shah et al., 2019)

        dsh75/dsh[+], kmr2 has trichome phenotype

        (Shami Shah et al., 2019)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Double-heterozygous flies of the genotype dsh[75]/+ together with either kmr1/+ or kmr2/+ display misoriented hair patterns on the wing, thorax and eyes, while single heterozygotes exhibit phenotypes similar to wild-type controls.

        (Shami Shah et al., 2019)

        Injection of nkddsRNA.cRa dsRNA has no effect on the dsh75 phenotype.

        (Rousset et al., 2001)

        The dsh75 mutant phenotype (embryos both maternally and zygotically homozygous for dsh75) is not affected if the embryos are also maternally and zygotically homozygous for Apc2ΔS.

        (McCartney et al., 1999)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer

        N. Perrimon.

        (Noordermeer et al., 1994)
        Comments
        Comments

        Used in mosaic analysis in the wing to examine the effect of inability to respond to wg signal.

        (Rulifson et al., 1996)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        dsh75
        (Clarembaux-Badell et al., 2022, Shami Shah et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (18)