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General Information
E. coli
FlyBase ID
Feature type
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ap-lacZ, aplacZ, aprK568, aprK568-lacZ, aprk560, aplacZ, apterous-lacZ, ap-Z
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
Additional Notes
(Li et al., 2016, Bieli et al., 2015, Lacin et al., 2014, Hasegawa et al., 2013, Li et al., 2013, Morante et al., 2013, Becam et al., 2011, Benito-Sipos et al., 2011, Chatterjee et al., 2011, Morante et al., 2011, Tripura et al., 2011, Karlsson et al., 2010, Baumgardt et al., 2009, Bejarano et al., 2008, Erclik et al., 2008, Erclik et al., 2008, Morante and Desplan, 2008, Baumgardt et al., 2007, de Navascu├ęs and Modolell, 2007, Soller et al., 2006, Campbell, 2005, Major and Irvine, 2005, McClure and Schubiger, 2005, del Alamo Rodriguez et al., 2004, Park et al., 2004, Yan et al., 2004, Allan et al., 2003, Baena-Lopez and Garcia-Bellido, 2003, Bernard et al., 2003, Janody et al., 2003, Milan and Cohen, 2003, Delanoue et al., 2002, Kozopas and Nusse, 2002, Zecca and Struhl, 2002, Zecca and Struhl, 2002, Milan et al., 2001, O'Keefe and Thomas, 2001, Weihe et al., 2001, Baonza et al., 2000, Ghazi et al., 2000, Roch and Akam, 2000, Wang et al., 2000, Brennan et al., 1999, Rauskolb et al., 1999, Rincon-Limas et al., 1999, Bachmann and Knust, 1998, Benveniste et al., 1998, de Celis et al., 1998, Klein et al., 1998, Maves and Schubiger, 1998, Milan et al., 1998, de Celis and Bray, 1997, Fleming et al., 1997, Gorfinkiel et al., 1997, Hukriede et al., 1997, Simmonds et al., 1997, de Celis et al., 1996, Doherty et al., 1996, Jonsson and Knust, 1996, Kadowaki et al., 1996, Larsen et al., 1996, Milan et al., 1996, Buratovich and Bryant, 1995, Diaz-Benjumea and Cohen, 1995, Rauskolb et al., 1995, Scanga et al., 1995, Blair, 1993, Williams et al., 1993, Cohen et al., 1992)
Associated Sequence Data
DNA sequence
Protein sequence
Progenitor genotype
Nature of the lesion
Insertion components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
No Assay Recorded
Tissue/Position (including subcellular localization)
distribution deduced from reporter
Tissue/Position (including subcellular localization)
distribution deduced from reporter (Gal4 UAS)
Tissue/Position (including subcellular localization)
Additional Information

At 12h APF, Ecol\lacZap-rK568 drives expression in one row of cells in the developing lamina, that co-expresses bsh protein. In adults, Ecol\lacZap-rK568 drives expression in lamina monopolar neuron L4, co-localising with bsh and dac.

Ecol\lacZap-rK568 transcript is expressed in both male and female genital discs of third instar larvae. Expression is more extensive and at a higher level in male than in female discs.

The expression of ey, ap, and Dll were compared in outer optic lobes (OPC) starting in late third instar larvae. At this stage they were expressed as three distinct cell populations. In anterior sections, the three genes are expressed a three parallele stripes of cells that represent rows of neurons that emerge from the OPC. They correspond to progeny from the youngest to oldest neuroblasts. In middle sections, Dll-positive cells are generated in the progeny of the oldest neuroblasts, with ey-positive and ap-positive cells often placed below Dll-positive (in cells that had emerged earlier from the these neuroblasts). By the beginning of pupation, the number of cells origination from the OPC increased. A major reorganization of optic lobe structure occurs around P20 such that the three stripes are no longer distinguishable and the three cell populations are extensively interspersed within the adult medulla cortex.

Ecol\lacZap-rK568 drives expression in the lamina monopolar L4 neurons and in 40% of the cells in the medulla cortex. Cells labeled with Ecol\lacZap-rK568 do not overlap with cells expressing Scer\GAL4ey-OK107 or Scer\GAL4Dll-md23.

Ecol\lacZap-rK568 is expressed in approximately 10 of the ~350 neurons in each hemisegment of the first instar larval ventral nerve cord. In each of the six thoracic hemisegments and in the third subesophageal hemisegments, Ecol\lacZap-rK568 is expressed in four or five cells.

Ecol\lacZ enhancer trap expression isobserved in larval and pupal imaginal discs. Expression is observedthroughout the parts of the of the wing and haltere discs that give riseto the dorsal surface of the wing and haltere blades, at lower levels inthe regions that form the notum and scutellum, and at the highest level inthe wing hinge region. Expression is also observed in the presumptivefourth tarsal segment of the ventral thoracic discs, in a central spot inthe antennal portion of the eye antennal disc, and in the larval brain.Ecol\lacZ expression can not be detected in the female germ line, the fatbody, or in Malpighian tubules.

Reporter construct used in assay
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Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
Disease-implicated variant(s)
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
External Data
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Xenogenetic Interactions
Complementation and Rescue Data
Images (0)
Stocks (1)
Notes on Origin
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (70)