FlyBase Allele Report: Dmel\aop[S2382]

General Information

Symbol

Dmel\aop^S2382

Species

D. melanogaster

Name

FlyBase ID

FBal0042854

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

Carried in Construct

Also Known As

yan^S2382

Key Links

Allele class

gain of function allele

neomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Rebay et al., 2000, Karim et al., 1996, Rebay and Rubin, 1995)

neomorphic allele - genetic evidence

(Rebay and Rubin, 1995)

Mutagen

Progenitor genotype

Cytology

Description

5bp deletion at nucleotide 2649 that shifts the open reading frame thereby replacing C terminal 162 amino acids with a new 86 amino acid tail.

(Rebay and Rubin, 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Karim et al., 1996, Rebay and Rubin, 1995)

visible | recessive

(Rebay et al., 2000)

Phenotype Manifest In

eye

(Rebay et al., 2000, Karim et al., 1996)

photoreceptor cell R1

(Karim et al., 1996)

photoreceptor cell R2

(Karim et al., 1996)

photoreceptor cell R3

(Karim et al., 1996)

photoreceptor cell R4

(Karim et al., 1996)

photoreceptor cell R5

(Karim et al., 1996)

photoreceptor cell R6

(Karim et al., 1996)

photoreceptor cell R7

(Karim et al., 1996, Rebay and Rubin, 1995)

Detailed Description

Statement

Reference

Eyes of homozygous flies have a slight roughening.

(Rebay et al., 2000)

Rough eye phenotype resulting from a failure of a proportion of R7 cells and outer photoreceptor cells to differentiate. Heterozygotes show a mild roughness near the anterior margin of the eye, and 25% of ommatidia are missing R7 cells. Homozygotes have slightly smaller eyes which are rough throughout the eye, and 75% of ommatidia are missing R7 cells and 20% are missing one or more outer photoreceptors.

(Karim et al., 1996)

Homozygous viable with a dominant rough eye phenotype due to missing photoreceptors, predominantly R7.

(Rebay and Rubin, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

aop^S2382/aop[+] is an enhancer of visible phenotype of lz^ts1

(Behan et al., 2002)

Other

Statement

Reference

aop^S2382, csw^lf has visible phenotype

(Firth et al., 2000)

aop^S2382, csw^lf has partially lethal phenotype

(Firth et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

aop^S2382 has eye phenotype, enhanceable by eya^G130

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by eya^A188

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by rl^A0648

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by Sos^D120

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by Sos^xB10

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by S^BA651

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by S^U132

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by EY2-6^AQR618

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by EY2-6^AC403

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by spen^AH393

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by spen^BU720

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by pnt^AP553

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by pnt^AF397

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by EY3-2^xAZ145

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by EY3-4^x1S805

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by EY3-5^xZB970

(Rebay et al., 2000)

aop^S2382 has eye phenotype, enhanceable by EY3-5^xKR845

(Rebay et al., 2000)

aop^S2382 has phenotype, enhanceable by Sos^EY2-3

(Chen et al., 1999)

NOT Enhanced by

Statement

Reference

aop^S2382 has phenotype, non-enhanceable by lilli^XS407

(Tang et al., 2001)

aop^S2382 has phenotype, non-enhanceable by lilli^XS575

(Tang et al., 2001)

aop^S2382 has phenotype, non-enhanceable by lilli^s35

(Tang et al., 2001)

aop^S2382 has phenotype, non-enhanceable by Su(Tpl)^DI998

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by Su(Tpl)^EZ1217

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by lilli^DE884

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by lilli^DR999

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by Sin3A^CY886

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by Sin3A^DW1046

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by Taf4^AG456

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by Taf4^I53

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by retn^B142

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by retn^x1N793

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY2-5^AH425

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by gl^DZ1053

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by gl^ER1085

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by stg^D115

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY2-5^DW1080

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY2-8^xCB204

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY2-8^EP1160

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY3-2^xCF301

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY3-2^xDF411

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY3-3^xBE183

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY3-3^xF6

(Rebay et al., 2000)

aop^S2382 has phenotype, non-enhanceable by EY3-4^xII790

(Rebay et al., 2000)

Suppressed by

Statement

Reference

aop^S2382 has eye phenotype, suppressible by stg^DD937

(Rebay et al., 2000)

NOT suppressed by

Statement

Reference

aop^S2382 has phenotype, non-suppressible by lilli^XS407

(Tang et al., 2001)

aop^S2382 has phenotype, non-suppressible by lilli^s35

(Tang et al., 2001)

aop^S2382 has phenotype, non-suppressible by lilli^XS575

(Tang et al., 2001)

aop^S2382 has phenotype, non-suppressible by EY2-5^AH425

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY2-5^DW1080

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by Su(Tpl)^EZ1217

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by lilli^DE884

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by lilli^DR999

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by Sin3A^CY886

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by Sin3A^DW1046

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by Taf4^AG456

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by Taf4^I53

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by retn^B142

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by retn^x1N793

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by gl^DZ1053

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY2-8^EP1160

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by gl^ER1085

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by stg^D115

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY2-8^xCB204

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY3-2^xCF301

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY3-2^xDF411

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY3-3^xBE183

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY3-3^xF6

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by EY3-4^xII790

(Rebay et al., 2000)

aop^S2382 has phenotype, non-suppressible by Su(Tpl)^DI998

(Rebay et al., 2000)

Enhancer of

Statement

Reference

aop^S2382/aop[+] is an enhancer of eye phenotype of lz^ts1

(Behan et al., 2002)

Suppressor of

Statement

Reference

aop^S2382 is a suppressor of phenotype of Ras85D^unspecified

(Rebay and Rubin, 1995)

Other

Statement

Reference

aop^S2382, csw^lf has ommatidium phenotype

(Firth et al., 2000)

aop^S2382, rl^AL528 has eye phenotype

(Rebay et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

aop^S2382/+ enhances the lz^ts1 phenotype at 29^oC, with defects extending throughout the eye.

(Behan et al., 2002)

csw^lf/Y ; aop^S2382/+ flies are poorly viable. Those flies that do eclose have extremely small, rough eyes.

(Firth et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Yan^S2382

(Rebay et al., 2000)

Yan^s2382

(Tang et al., 2001)

aop^S2382

yan^S2382

(Behan et al., 2002, Chen et al., 1999)

yan^XS-2382

(Firth et al., 2000)

yan^XS-S2382

(Karim et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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