FB2022_03, released June 9, 2022

Allele: Dmel\hidA22

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General Information
Symbol
Dmel\hidA22
Species
D. melanogaster
Name
FlyBase ID
FBal0045274
Feature type
allele
Associated gene
Dmel\hid
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Abbott and Lengyel, 1991)
Mutagen
X ray
(Abbott and Lengyel, 1991)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point_mutation
3L:18,173,375..18,173,375 [-]
Nucleotide change:

C18173375T

Reported nucleotide change:

C910T

Amino acid change:

P171S | hid-PA; P171S | hid-PB

Reported amino acid change:

P170S

(Grether et al., 1995)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Amino acid replacement: P170S.

      (Grether et al., 1995)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Surviving transheterozygotes with Whid-A22 or Whid-A206 have an abnormal wing phenotype. The mutant wing appears opaque by comparison to wild type and occasionally contains trapped fluid. Transheterozygous males also possess improperly positioned terminalia. Some hemizygotes die before hatching and most of those that hatch possess properly formed cephalopharyngeal skeleton.

      (Abbott and Lengyel, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutant males can be ranked based on the severity of terminalia rotation: Df(3L)H99 > Whid-H109 > Whid-A22 > Whid-A206 > Whid-A329 > Whid-H89. The ranking is roughly similar to the one for the degree to which the alleles disrupt embryonic head development.

      (Abbott and Lengyel, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (9)