FB2020_06, released Dec 22, 2020

Allele: Dmel\hidH109

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General Information
Symbol
Dmel\hidH109
Species
D. melanogaster
Name
FlyBase ID
FBal0045276
Feature type
allele
Associated gene
Dmel\hid
Associated Insertion(s)
Carried in Construct
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Abbott and Lengyel, 1991)
Mutagen
gamma ray
(Abbott and Lengyel, 1991)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Whid-H109 heterozygotes show wild-type levels of survival when exposed to 0-8000 R of X-rays.

      (Jaklevic et al., 2008)

      The wing discs of Whid-H109/+ mutant third instar larvae exhibit reduced levels of apoptosis in response to X-ray induced irradiation with 4000 rads compared to controls.

      (Brodsky et al., 2004)

      Hemizygotes die before hatching and possess an improperly formed cephalopharyngeal skeleton, all components are present but do not show their normal spatial relationship to each other.

      (Abbott and Lengyel, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutant males can be ranked based on the severity of terminalia rotation: Df(3L)H99 > Whid-H109 > Whid-A22 > Whid-A206 > Whid-A329 > Whid-H89. The ranking is roughly similar to the one for the degree to which the alleles disrupt embryonic head development.

      (Abbott and Lengyel, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Whid-H109
      hidH109
      (Jaklevic et al., 2008, Brodsky et al., 2004, Abbott and Lengyel, 1991)
      hidhid-H109
      Name Synonyms
      Secondary FlyBase IDs
        References (4)