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General Information
Symbol
Dmel\Cyt-b5k09716
Species
D. melanogaster
Name
FlyBase ID
FBal0045504
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dpldMLB
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion within the 5' UTR of Cyt-b5, at position -65 relative to the translation start codon.

Insertion components
P{lacW}Cyt-b5k09716
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous and Cyt-b5k14202/Cyt-b5k09716 females and males produce few progeny, even when mated with wild-type flies, and the mutant females lay few eggs.

Cyt-b5k14202/Cyt-b5k09716 larvae contain large numbers of circulating lamellocytes (these are not found in normal larvae). Lamellocytes are more prevalent in larvae containing small melanotic tumours, while plasmatocytes are more abundant in larvae containing large melanotic tumours.

All larvae and adults exhibit melanotic tumour formation. Adult tumours are in the abdomen and occasionally in the head and thorax.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The melanotic tumour phenotype seen in Cyt-b5k14202/Cyt-b5k09716 animals is rescued by expression of Cyt-b5Scer\UAS.cKa under the control of Scer\GAL4He.PZ, but is not rescued when expression is driven by Scer\GAL4Sgs3.PD.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

Level of Ecol\lacZ expression and viability of adults is not altered by bacterial infection of adults.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)