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General Information
Symbol
Dmel\gcmrA87
Species
D. melanogaster
Name
FlyBase ID
FBal0045767
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rA87, gcm-lacZ, gcm-lacZrA87
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of P{PZ} at position -82 from transcription start site.

P-element insertion 109bp 5' to the end of the longest cDNA.

Insertion components
P{PZ}gcmrA87
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

gcmrA87.P/gcmrA87 transheterozygous females present a significant reduction in the numbers of eggs laid and progeny, but the corresponding males present no defects in the number of progeny, as compared to controls; most of the female's spermathecae exhibit a complete loss of secretory cells, although some remain in a few cases.

Loss of gcm in gcmrA87 mutants results in embryonic lethality accompanied by the almost complete absence of glial cells and reduction in macrophages.

The total loss of glia in gcmrA87 mutant embryos causes neuronal pathfinding defects in stage 16 embryos. The cerebral trachea grows towards the dorsomedial surface of the neuropile normally. However, upon reaching the neuropile surface, it gives off numerous thick, long branches that are never observed in wild-type embryos.

Homozygotes exhibit an abnormal and variable number of ectopic sensory organs in the region of the twin sensillum on the wing margin (TSM).

Transheterozygotes with gcm- alleles are viable.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

gcm Dys double heterozygous flies (gcmrA87/Df(3R)Exel6184) do not exhibit indirect flight muscle degeneration.

One copy of gcmrA87 does not enhance the indirect flight muscle degeneration seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

One copy of gcmrA87 does not enhance the indirect flight muscle degeneration seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

gcmrA87 Dg323 double heterozygous flies do not exhibit indirect flight muscle degeneration.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Lethal excision lines have been generated by Δ2-3 mediated P-element excision, gcm26 and gcm34.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)