FlyBase Allele Report: Dmel\inv[E]

General Information

Symbol

Dmel\inv^E

Species

D. melanogaster

Name

FlyBase ID

FBal0045909

Feature type

allele

Associated gene

Dmel\inv

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tabata et al., 1995)

Mutagen

Progenitor genotype

Caused by aberration

Df(2R)en^E

Cytology

Description

Df(2R)en^E breaks at approximate coordinate 0 and -50 in the inv-en region.

(Gustavson et al., 1996)

Deletion removing the C-terminal three exons of inv.

(Tabata et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anterior-posterior compartment boundary of the wing blade

(Blair and Ralston, 1997)

larval longitudinal connective

(Siegler and Jia, 1999)

presumptive embryonic/larval muscle system

(Siegler and Jia, 1999)

symmetrical commissure | embryonic stage

(Siegler and Jia, 1999)

wing

(Blair and Ralston, 1997)

wing vein | ectopic

(Blair and Ralston, 1997)

Detailed Description

Statement

Reference

Con-positive longitudinal fascicles and commissures are grossly disturbed in Df(2R)en^E embryos (carrying both en^E and inv^E). The muscles are grossly abnormal.

(Siegler and Jia, 1999)

en^E inv^E double mutant clones of posterior origin show a variety of phenotypes in the wing. Clones distant from the A/P compartment boundary induce outgrowths and duplications both in and adjacent to the clones. Posterior clones at the A/P boundary sometimes cross into or displace the A/P boundary, while others straddle the normal site of the A/P restriction. Outgrowths and ectopic or disrupted venation are sometimes seen at the site of the normal A/P boundary. In a few rare cases, clones appear to obey the A/P lineage restriction from the posterior side. Posterior clone cells that have crossed or displaced the A/P boundary do not associate normally with anterior cells.

(Blair and Ralston, 1997)

Embryos fail to complete embryogenesis: defects are more extreme than for simple en mutant, en⁸ or simple inv allele, inv³⁰.

(Tabata et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

en^E, inv^E has embryonic hindgut phenotype

(Iwaki and Lengyel, 2002, Takashima and Murakami, 2001)

en^E, inv^E has neuroblast NB7-3 phenotype

(Deshpande et al., 2001)

en^E, inv^E has wing disc | posterior | somatic clone phenotype

(Dahmann and Basler, 2000)

ci⁹⁴, en^E, inv^E has wing disc | posterior | somatic clone phenotype

(Dahmann and Basler, 2000)

en^E, inv^E, smo³ has wing disc | posterior | somatic clone phenotype

(Dahmann and Basler, 2000)

en^E, inv^E has larval somatic muscle cell phenotype

(Martin-Bermudo and Brown, 2000)

en^E, inv^E has tendon cell phenotype

(Martin-Bermudo and Brown, 2000)

en^E, inv^E has larval RP2 motor neuron phenotype

(Bhat and Schedl, 1997)

en^E, inv^E, wg^hs.PN has larval RP2 motor neuron | ectopic phenotype

(Bhat and Schedl, 1997)

Df(2R)gsb, en^E, inv^E has neuroblast NB5-3 phenotype

(Bhat and Schedl, 1997)

Df(2R)gsb, en^E, inv^E has larval RP2 motor neuron | ectopic phenotype

(Bhat and Schedl, 1997)

Df(2R)gsb, en^E, inv^E has neuroblast NB5-6 phenotype

(Bhat and Schedl, 1997)

en^E, inv^E has neuroblast NB5-3 phenotype

(Bhat and Schedl, 1997)

en^E, inv^E has larval RP2 motor neuron | ectopic phenotype

(Bhat and Schedl, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Df(2R)en^E mutant embryos (carrying both inv^E and en^E) completely lack hindgut boundary cell rows and rings.

(Iwaki and Lengyel, 2002)

Neuroblast NB 7-3 is missing in 100% of Df(2R)en^E hemisegments (in which embryos are mutant for both en and inv).

(Deshpande et al., 2001)

Df(2R)en^E embryos (which are mutant for both en and inv) show slight overgrowth of the hindgut, although its overall morphology is almost normal. The border cells of the hindgut (which normally form an anterior and posterior ring at the ends of the hindgut and bilateral strands that connect the two rings) do not differentiate in these embryos.

(Takashima and Murakami, 2001)

Df(2R)en^E clones (mutant for both en and inv) of posterior origin in the wing disc sort, when in contact with anterior cells, into anterior territory. Df(2R)en^E; ci⁹⁴ double mutant clones of anterior origin in the wing disc straddle the anterior/posterior (A/P) boundary, similar to ci⁹⁴ single mutant clones. Unlike Df(2R)en^E single mutant posterior clones, however, Df(2R)en^E; ci⁹⁴ double mutant clones of posterior origin only partially sort into anterior territory and straddle the A/P boundary (similar to ci⁹⁴ or Df(2R)en^E; ci⁹⁴ clones originating in the anterior compartment). Df(2R)en^E; ci⁹⁴ double mutant clones of both anterior and posterior origin define straight borders with neighbouring wild-type anterior and posterior cells. Df(2R)en^E; ci⁹⁴ double mutant clones show smooth borders with adjacent wild-type cells when situated entirely within the posterior compartment. Unlike Df(2R)en^E single mutant clones, Df(2R)en^E smo³ double mutant clones of posterior origin in the wing disc invariably occupy only posterior territory and define straight borders to anterior cells at the normal position of the anterior/posterior (A/P) boundary. Df(2R)en^E smo³ double mutant clones of anterior origin also occupy posterior territory and define straight borders to anterior cells at the normal position of the A/P boundary.

(Dahmann and Basler, 2000)

The specification of the majority of tendon cells is eliminated in Df(2R)en^E embryos. Some muscles in these embryos have abnormal free ends.

(Martin-Bermudo and Brown, 2000)

en^E inv^E embryos have duplicated RP2 neurons in several hemisegments. This is due to the transformation of the NB5-3 neuroblast to a NB4-2 fate. en^E inv^E embryos expressing wg^hs.PN, or en^E inv^E Df(2R)gsb triple mutants have triplicated RP2 neurons. The triplication in en^E inv^E Df(2R)gsb embryos is due to transformation of the NB5-3 and NB5-6 neuroblasts to a NB4-2 fate. gsb^hs.PBH prevents the duplication of RP2 neurons seen in en^E inv^E embryos when expressed during stage 8. ptc⁹ en^E inv^E triple mutants lack RP2 neurons.

(Bhat and Schedl, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

2216

f^36a; Df(2R)en^E, inv^E en^E/CyO; mwh¹ jv¹ P{f⁺13}77A/TM2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

inv^E

(Bailetti et al., 2019, Bridi et al., 2019, Pérez et al., 2011, Joly et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (16)

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