Open Close
General Information
Symbol
Dmel\dibunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0049409
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Mutant embryos have alterations in embryonic morphology. No epidermal folds are found below the ventral nerve cord. Instead of stretching dorsally, the ectoderm appears to fold like an accordion in the anterior-posterior axis. As a consequence the gut is frequently pushed outside the embryo. By the end of embryogenesis the ventral folding of the epidermis pushes the ventral nerve cord further deep into the embryo. Beside the dorsal closure phenotypes, defects are also seen during head involution and in gut morphology. Mutant embryos also typically have fused commissure phenotypes where anterior and posterior commissures are not separated. Longitudinal connectives are also often reduced and frequent gaps may be seen in tracts. Glial cell organisation is severely affected in mutants. Mutants have a significant increase in the number of midline glial cells. About 6 cells are seen per neuromere.

    Cuticle and head structures are undifferentiated in dibunspecified mutant embryos.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhanced by
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    In dibunspecified, BacA\p35Scer\UAS.cHa, Scer\GAL4sim.PS embryos, about 10 midline glial cells are seen per neuromere.

    Xenogenetic Interactions
    Statement
    Reference

    In dibunspecified, BacA\p35Scer\UAS.cHa, Scer\GAL4sim.PS embryos, about 10 midline glial cells are seen per neuromere.

    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Eleven alleles have been isolated.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    dibunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (5)