Open Close
General Information
Symbol
Dmel\kek1RM2
Species
D. melanogaster
Name
FlyBase ID
FBal0051472
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
RM2
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{lArB} insertion.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eggs derived from kek1RA5/kek1RM2 females have thin and widely spaced dorsal appendages.

kek1RA5/kek1RM2 animals have patches of ectopic vein in the wing (72.3% penetrance).

Eggs derived from kek1RA5/kek1RM2 females are mildly dorsalised; the spacing between the dorsal appendages is increased compared to wild-type. The eggs are slightly shorter and rounder than normal. This weak dorsalisation does not interfere with fertility.

No major abnormalities are seen in the CNS of homozygous embryos, although partial defasciculation of Fas2 expressing axon bundles is occasionally seen.

kek1RA5/kek1RM2 heterozygotes are viable, fertile, lay eggs with normal morphology and resulting adults have no obvious visible phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

kek1RA5/kek1RM2 is a suppressor of visible phenotype of Egfrt1/Egfrf24

Phenotype Manifest In
Enhanced by
Statement
Reference

kek1RA5/kek1RM2 has egg phenotype, enhanceable by grk+t9

Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Heterozygous kek1RM2 or kek1RA5 partially suppresses the rough eye phenotype seen Egfrflb-2E07/Egfrt1 animals. kek1RM2/kek1RA5 fully suppresses the phenotype.

The loss of wing vein L4 seen in Egfrt1/Egfrf24 animals is suppressed if they are also mutant for kek1 (kek1RA5/kek1RM2).

The dorsalised phenotype of eggs derived from kek1RA5/kek1RM2 females is enhanced by one copy of grk+t9. The ventralised phenotype of eggs derived from Egfrt1/Egfrflb-2E07 females is partially suppressed by kek1RA5/kek1RM2.

Extension of longitudinal axons through the intercommissural region is frequently abnormal in kek1RM2; Nrt5 and kek1RA5/kek1RM2 ; Nrt5 embryos. In addition, Fas2 expressing axons show defasciculation, stalling and guidance defects, including crossing of the midline. The stalling and misguidance phenotypes can be rescued by NrtScer\UAS.cSa expressed under the control of Scer\GAL4Mz1277.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)