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General Information
Symbol
Dmel\l(3)mbtunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0057055
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Larvae develop a brain tumour at 29oC and die around the time of puparium formation. The invasive tumour consists of adult optic neuroblasts and optic ganglion mother cells. The temperature-sensitive period for tumour formation spans the embryonic, first and second larval instar stages. During this time, brain tumour development is reversible upon shifting animals down to 22oC, but during the third larval instar stage the brain tumour becomes irreversibly established. Shifting to the restrictive temperature after the temperature-sensitive phase for tumour formation and during adult life causes female sterility. The defects in oogenesis correlate with the developmental time of the shift to the restrictive temperature. In the earliest temperature shifts, oogenesis is arrested at the stem cell stage, while germaria shifted at later stages show fused egg chambers. Ovaries that have differentiated germaria at the time of the temperature shift form individualised egg chambers, but the eggs are short and incapable of further development. About 25% of eggs from late shifted females develop into segmented embryos, most of which have head defects. About half of these embryos also have thoracic and abdominal segment abnormalities.

    External Data
    Interactions
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    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    l(3)mbtunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (1)