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General Information
Symbol
Dmel\Fatp1k10307
Species
D. melanogaster
Name
FlyBase ID
FBal0064213
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)k10307, fatpk10307, dFatpK10307
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{lacW}Fatp1k10307
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Fatp1k10307 drives expression in the secondary and tertiary pigment cells, and in neurons in the adult retina. Expression is also detected at the level of the photoreceptors and in cells around the medulla and lamina.

 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones in the retina show progressive loss of photoreceptor cells in the adult. This defect is cell-autonomous. Significantly greater photoreceptor loss is seen in flies reared in normal light conditions compared to those reared in complete darkness.

The amplitude of the electroretinogram is increased in 8 day old adults containing homozygous retinas compared to that of control flies.

Heterozygous flies have significantly increased triglyceride and glycogen levels compared to age-matched control flies. Free fatty acid levels in the circulating hemolymph are significantly increased in heterozygous males compared to wild type.

Heterozygous flies show a significantly reduced feeding rate compared to controls.

Heterozygous females show an increase in lifespan compared to controls in two or three genetic backgrounds tested.

Heterozygous males and females aged on high-yeast or high-fatty acid (palmitic acid) diets live longer than controls.

Heterozygous males show significantly increased resistance to chronic heat stress (28[o]C) compared to controls. Heterozygous females, but not heterozygous males show significantly increased resistance to cold stress (4[o]C) compared to controls.

Heterozygous males and females show significantly increased resistance to oxidative stress (paraquat) compared to controls.

Heterozygous males and females show significantly increased resistance to starvation conditions compared to controls.

The rate of cardiac failure in response to pacing stress is significantly higher across ages in heterozygous adults compared to controls. The frequency of the heart rate is increased across ages in heterozygous flies compared to controls, and the mutant hearts show a reduction in fractional shortening.

Heterozygous flies show a significantly slower age-related decline in negative geotaxis ability compared to controls. Heterozygous males show a significant degree of improvement in negative geotaxis following a 3-week training period of endurance exercise, with the improvement being similar in magnitude to wild type.

The increased triglyceride levels seen in heterozygous flies are somewhat reduced by exercise training, although not to wild-type levels. The reduced feeding rate of heterozygous flies is unaffected by exercise. Exercise training of heterozygous flies results in a significant rescue of the fractional shortening defect of the heart, and the increased frequency of the heart rate seen in the mutant flies is also reduced.

Homozygous clones in the retina show loss of photoreceptor cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The photoreceptor degeneration observed in adult flies bearing ey>flip whole-eye clones mutant for either sicilyE or MarfB is improved by Fatpk10307 heterozygosity.

The presence of ninaEG69D/+ or of ninaE17/+ rescues the photoreceptor degeneration phenotype seen in Fatpk10307 clones in the retina.

The photoreceptor degeneration phenotype seen in Fatpk10307 clones in the retina is suppressed if the retinas are also mutant for Arr23.

Xenogenetic Interactions
Statement
Reference

Expression of BacA\p35GMR.PH suppresses the loss of photoreceptor cells which is seen in homozygous Fatpk10307 clones in the retina.

Complementation and Rescue Data
Comments

Expression of FatpScer\UAS.cDa under the control of Scer\GAL4ninaE.PT fully rescues the photoreceptor degeneration phenotype seen in Fatpk10307 clones in the retina.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Complements: RpS27A04820. Complements: l(2)k02605k02605. Complements: l(2)k03906ak03906a. Complements: l(2)k09015ak09015a. Complements: l(2)k09116k09116. Complements: UbcD2k13206.

Precise excision of the insertion reverts the mutant phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (14)