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General Information
Symbol
Dmel\hthC1
Species
D. melanogaster
Name
FlyBase ID
FBal0065835
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G10585928A

Reported nucleotide change:

G1793A

Amino acid change:

V181I

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G1793A. Amino acid replacement: V181I.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos show a reduction in the number of LCh5 neurons, loss of thoracic DCh3 neurons and an abnormal pattern of the axonal trajectories in the PNS.

Somatic clones in the head, induced during larval stages, lead to ectopic eye structures in the head. the ventral head region (gena and rostral membrane) is reduced as a consequence of the production of ectopic eyes, and the maxillary palps are frequently absent or abnormal in these clones.

Homozygous hthC1 somatic clones are capable of differentiating bristles.

Homozygous clones in the distal antenna show transformation to distal leg. Clones in tergites 2 and 3 in males result in a darkly pigmented cuticle, typical of a posterior tergite identity. Homozygous clones in anterior tergites in males also have a lower density of trichomes than surrounding wild-type cuticle, indicating a transformation to a more posterior identity.

Homozygous clones in the leg cause fusion of the coxa, trochanter and femur segments but do not cause defects in distal leg segments.

Clones in the antenna exhibit autonomous transformation to leg.

The normal pattern of the cuticle is disrupted in homozygous embryos and hthC1/Df(3R)hth embryos, with hthC1/Df(3R)hth embryos having a stronger phenotype than homozygous embryos. The denticle belts of the thoracic segments have an abdominal-like morphology in homozygous embryos, and the first abdominal segment is transformed to an identity resembling the fifth abdominal segment. In addition, segmental fusions are seen in hthC1/Df(3R)hth embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The abdominal segments of AntpNs-rvC3 ScrC1 abd-AM1 Abd-BM8 hthC1 mutant embryos all resemble the third abdominal segment. Ubiquitous expression of UbxIa.hs in hthC1/hthC1 embryos transforms all three thoracic segments and 2-3 head segments into A5-like segments. Cuticles secreted by exd1 embryos lacking both maternal and zygotic exd function appear indistinguishable from those secreted by exd1 embryos lacking both maternal and zygotic exd function and also hemizygous for hthC1. exd1/exd1; hthC1/hthC1 double mutant embryos have stronger transformations than either exd1/exd1 or hthC1/hthC1 single mutant embryos. The homozygous embryonic phenotype is partially rescued by Mmus\Meis1hs.T:Hsap\MYC.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Germ line clonal analysis indicates that hth function is not required maternally.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)