FlyBase Allele Report: Dmel\EcR[A.hs]

General Information

Symbol

Dmel\EcR^A.hs

Species

D. melanogaster

Name

FlyBase ID

FBal0083502

Feature type

allele

Associated gene

Dmel\EcR

Associated Insertion(s)

Carried in Construct

P{hs-EcR.A}

Also Known As

hs-EcR.A

Key Links

Transgenic product class

wild_type

(Bender et al., 1997)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Bender et al., 1997)

Mutagen

in vitro construct

(Bender et al., 1997)

Progenitor genotype

Carried in construct

P{hs-EcR.A}

Cytology

Description

Construct: The EcR-A isoform is expressed under the control of a heat shock promoter.

(Bender et al., 1997)

Allele components

Component

Use(s)

Encoded product / tool

EcR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Kucherenko et al., 2012)

partially lethal | heat sensitive

(Schubiger et al., 2003)

Phenotype Manifest In

adult mushroom body beta-lobe

(Kucherenko et al., 2012)

female germline cell | increased number | heat sensitive

(König et al., 2011)

fusome | heat sensitive

(König et al., 2011)

lobe system of adult mushroom body

(Kucherenko et al., 2012)

Detailed Description

Statement

Reference

Animals expressing EcR^A.hs have defects in the mushroom body α/β lobes: the lobes may appear slim or underdeveloped, or the β lobes may be fused.

(Kucherenko et al., 2012)

Expression of EcR^A.hs using heat shock results in germaria that are filled with supernumerary germline cells containing a single spectrosome in females. After 7 days of heat shock treatment, 67% of germaria contain dumbbell-shaped fusomes.

(König et al., 2011)

Heat induced expression of EcR^A.hs (using a single heat shock for 45 minutes at 37^oC) has little effect on viability with only 15-25% of the animals dying when the heat shock is administered at the time of the ecdysone peak.

(Schubiger et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

EcR^A.hs partially rescues EcR^M554fs/EcR^V559fs

(Li and Bender, 2000)

Comments

Expression of EcR^A.hs via heat pulses every 12 hours during development can efficiently rescue EcR^M554fs/EcR^V559fs animals to the first larval instar stage (100% rescue).

(Li and Bender, 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4933

w¹¹¹⁸; P{hs-EcR.A}60.19

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

EcR^A.hs

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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