FlyBase Allele Report: Dmel\zip[Ebr]

General Information

Symbol

Dmel\zip^Ebr

Species

D. melanogaster

Name

FlyBase ID

FBal0088529

Feature type

allele

Associated gene

Dmel\zip

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

2R:24,997,064..24,997,064 [-]

Nucleotide change:

G24997064A

Reported nucleotide change:

G14374A

Amino acid change:

Reported amino acid change:

R276H

(Halsell et al., 2000)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: R277H.

(Halsell and Kiehart, 2000)

Nucleotide substitution: G14374A. Amino acid replacement: R276H. Nucleotide coordinates are relative to the sequence record U35816. Amino acid coordinates are relative to the transcript published in FBrf0052857.

(Halsell et al., 2000)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Baumann, 2004, Bayer et al., 2003, Halsell et al., 2000, Halsell and Kiehart, 1998)

partially lethal - majority live (with zip^33-1)

(Bayer et al., 2003)

some die during embryonic stage (with zip²)

(Boettner and Van Aelst, 2007)

visible (with zip^33-1)

(Bayer et al., 2003)

visible (with zip⁰²⁹⁵⁷)

(Mizuno et al., 2002)

Phenotype Manifest In

embryo (with zip²)

(Boettner and Van Aelst, 2007)

eye (with zip⁰²⁹⁵⁷)

(Baumann, 2004)

leg (with zip^33-1)

(Bayer et al., 2003)

pigment cell (with zip⁰²⁹⁵⁷)

(Baumann, 2004)

retina (with zip⁰²⁹⁵⁷)

(Baumann, 2004)

rhabdomere (with zip⁰²⁹⁵⁷)

(Baumann, 2004)

wing (with zip⁰²⁹⁵⁷)

(Baumann, 2004, Mizuno et al., 2002)

Detailed Description

Statement

Reference

zip^Ebr/zip⁰²⁹⁵⁷ transheterozygotes are viable but have malformed wings with varying degrees of severity. Mutants also have rough eyes. In these retina the Mysoin-II system is disorganised . Some rhabdomeres have gaps along their lengths. Moreover, the rhabdomeres are not as straight as in wild-type, but appear to meander slightly. At the retinal floor of mutants, the hexagonal arrangement of the pigment cell pedicels exhibit irregularities, moreover, the retinal floor is not completely flattened but wrinkled in some areas.

(Baumann, 2004)

zip^Ebr/zip^33-1 animals have a severe leg malformation phenotype.

(Bayer et al., 2003)

About 70% of zip^Ebr/zip⁰²⁹⁵⁷ adults have malformed wings.

(Mizuno et al., 2002)

Mutants die as late embryos or early larvae.

(Halsell et al., 2000)

Lethality acts post-embryonically.

(Halsell and Kiehart, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

zip²/zip^Ebr has increased mortality during development phenotype, enhanceable by cno^mis1/cno²

(Boettner and Van Aelst, 2007)

zip²/zip^Ebr has increased mortality during development phenotype, enhanceable by PDZ-GEF^k13720/PDZ-GEF^C2

(Boettner and Van Aelst, 2007)

Suppressed by

Statement

Reference

Rho1^72BH, zip^Ebr has visible | dominant phenotype, suppressible by Mbs³

(Mizuno et al., 2002)

RhoGEF2⁰⁴²⁹¹, zip^Ebr has visible | dominant phenotype, suppressible by Mbs³

(Mizuno et al., 2002)

Rho1^72O, zip^Ebr has visible | dominant phenotype, suppressible | partially by Mbs³

(Mizuno et al., 2002)

zip⁰²⁹⁵⁷/zip^Ebr has visible phenotype, suppressible | partially by Mbs³/Mbs[+]

(Mizuno et al., 2002)

Rok², zip^Ebr has visible | dominant phenotype, suppressible by Mbs³

(Mizuno et al., 2002)

Enhancer of

Statement

Reference

zip²/zip^Ebr is an enhancer of increased mortality during development phenotype of cno^mis1/cno²

(Boettner and Van Aelst, 2007)

zip²/zip^Ebr is an enhancer of abnormal cell migration | embryonic stage phenotype of cno^mis1/cno²

(Boettner and Van Aelst, 2007)

zip²/zip^Ebr is an enhancer of increased mortality during development phenotype of PDZ-GEF^k13720/PDZ-GEF^C2

(Boettner and Van Aelst, 2007)

zip[+]/zip^Ebr is an enhancer of visible | dominant phenotype of Sb⁷⁰

(Chen et al., 2004)

zip[+]/zip^Ebr is an enhancer of visible | dominant phenotype of Sb^63b

(Chen et al., 2004)

zip[+]/zip^Ebr is an enhancer of visible | dominant phenotype of br¹

(Chen et al., 2004)

Suppressor of

Statement

Reference

zip^Ebr is a suppressor of lethal | recessive | larval stage phenotype of Moe^G0323

(Speck et al., 2003)

zip[+]/zip^Ebr is a suppressor of lethal | embryonic stage phenotype of Scer\GAL4^arm.PS, Rok^UAS.cMa

(Mizuno et al., 2002)

zip[+], zip^Ebr, Scer\GAL4[-] is a suppressor of lethal | maternal effect | embryonic stage phenotype of Mbs^EP3727/Df(3L)th117, Mbs³

(Mizuno et al., 2002)

zip[+], zip^Ebr, Scer\GAL4[-] is a suppressor of lethal | maternal effect | embryonic stage phenotype of Mbs³/Df(3L)th117, Mbs^EP3727

(Mizuno et al., 2002)

Other

Statement

Reference

Scer\GAL4^dpp.PU, fwe^{UASp.Lose-A.C.Tag:HA}, zip²/zip^Ebr has increased cell death phenotype

(Levayer et al., 2015)

PDZ-GEF^k13720/PDZ-GEF^C2, zip²/zip^Ebr has abnormal cell migration | embryonic stage phenotype

(Boettner and Van Aelst, 2007)

cno^mis1/cno², zip^Ebr has visible | adult stage phenotype

(Boettner and Van Aelst, 2007)

Sb⁷⁰, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

Rok², zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^4.1, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003, Halsell et al., 2000)

E(zip)18-5^18-5, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], zip^Ebr has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok², zip^Ebr has visible phenotype

(Bayer et al., 2003)

Rok¹, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003, Halsell et al., 2000)

Rho1^12-6, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^12-6, zip[+]/zip^Ebr has partially lethal phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, zip^Ebr has visible phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, zip^Ebr has visible phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6/E(zip)31-6[+], zip^Ebr has visible phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], zip^Ebr has visible phenotype

(Bayer et al., 2003)

RhoGEF2^1.1/RhoGEF2[+], zip^Ebr has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], zip^Ebr has visible phenotype

(Bayer et al., 2003)

RhoGEF2^4.1/RhoGEF2[+], zip^Ebr has visible phenotype

(Bayer et al., 2003)

Sb[+]/Sb⁷⁰, zip^Ebr has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, zip^Ebr has visible phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003, Halsell et al., 2000)

Sb^Ebr536, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

E(br)444^Ebr444, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

E(br)65^Ebr65, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

E(br)121^Ebr121/E(br)121[+], zip^Ebr has visible phenotype

(Ward et al., 2003)

E(br)160[+]/E(br)160^Ebr160, zip^Ebr has visible phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, zip^Ebr has visible phenotype

(Ward et al., 2003)

E(br)65^Ebr65/E(br)65[+], zip^Ebr has visible phenotype

(Ward et al., 2003)

Rho1^Ebr233/Rho1[+], zip^Ebr has visible phenotype

(Ward et al., 2003)

Rho1[+]/Rho1^Ebr246, zip^Ebr has visible phenotype

(Ward et al., 2003)

Sb[+]/Sb^Ebr20, zip^Ebr has visible phenotype

(Ward et al., 2003)

Sb[+]/Sb^Ebr448, zip^Ebr has visible phenotype

(Ward et al., 2003)

Sb[+]/Sb^Ebr48, zip^Ebr has visible phenotype

(Ward et al., 2003)

Sb[+]/Sb^Ebr536, zip^Ebr has visible phenotype

(Ward et al., 2003)

Sb^Ebr623/Sb[+], zip^Ebr has visible phenotype

(Ward et al., 2003)

Rho1^Ebr233, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

E(br)121^Ebr121, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Sb^Ebr48, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Sb^Ebr448, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Sb^Ebr623, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Rho1^Ebr246, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Sb^Ebr20, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

E(br)160^Ebr160, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Rho1^72O, zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002, Halsell et al., 2000)

RhoGEF2⁰⁴²⁹¹, zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002, Halsell et al., 2000)

Rho1^72BH, zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002)

Rho1^72BH/Rho1[+], zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002)

Rho1^72O/Rho1[+], zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002)

rok[+]/Rok², zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002)

Rok², zip^Ebr has visible | dominant phenotype

(Mizuno et al., 2002)

Df(2R)Jp8/+, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000, Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000, Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

Rho1^J3.8, zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell et al., 2000)

Rho1^J3.8, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

Rho1^72F, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

RhoGEF2^1.1, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

RhoGEF2^4.1, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

+/Df(2R)Jp4, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

Rho1^72O, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

Rho1^72F, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000, Halsell and Kiehart, 1998)

Rho1^E3.10, zip[+]/zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell et al., 2000)

vkg⁰¹²⁰⁹, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)JC70/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)RA2/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)v-L15/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

vkg^k09511, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)v-N48/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)HA85/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)r-D1/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)30A-C/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)H20/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)TW50/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

+/In(2R)bw^VDe2LCy^R, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)nap1/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)Jp1/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

In(2LR)Px⁴/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)W10/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)cl-h3/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)bw^VDe2LPx^KR/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)81k19/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)81k19/+, zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell and Kiehart, 1998)

+/Df(3L)st4, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)st7/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)st-b11/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Tm1[+]/Tm1^eg9, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

vkg[+]/vkg⁰¹²⁰⁹, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

vkg^k09511/vkg[+], zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Rho1^E3.10/Rho1[+], zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Rho1^E3.10/Rho1[+], zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8/Rho1[+], zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8/Rho1[+], zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)Jp8, zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)64c18/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has partially lethal - majority live phenotype

(Halsell and Kiehart, 1998)

Df(1)A113/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

+/Df(1)ct-J4, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)ct4b1/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Tm1^eg9, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)g/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Tm1^er4, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Rho1^E3.10, zip[+]/zip^Ebr has partially lethal - majority live phenotype

(Halsell and Kiehart, 1998)

Df(1)HF396/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)JS32/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)sc19-5/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)TE29Aa-11/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)J39/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2L)osp29/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

+/Df(2R)M41A4, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)B5/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)vg-C/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)CX1/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)PC4/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(2R)or-BR6/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)M21/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)HR370/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)HR119/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)GN24/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)AC1/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)Cat/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)rdgC-co2/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3L)Pc-MK/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(1)sc-J4/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Df(3R)ea/+, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

zip²/zip^Ebr has embryo phenotype, enhanceable by PDZ-GEF^k13720/PDZ-GEF^C2

(Boettner and Van Aelst, 2007)

NOT Enhanced by

Statement

Reference

zip^Ebr has phenotype, non-enhanceable by Eip74EF^DL-1

(Halsell and Kiehart, 1998)

zip^Ebr has phenotype, non-enhanceable by Eip74EF^neo24

(Halsell and Kiehart, 1998)

zip^Ebr has phenotype, non-enhanceable by Khc⁸

(Halsell and Kiehart, 1998)

zip^Ebr has phenotype, non-enhanceable by l(2)52Fb^D2.33

(Halsell and Kiehart, 1998)

zip^Ebr has phenotype, non-enhanceable by l(2)52Fc^D8.13

(Halsell and Kiehart, 1998)

zip^Ebr has phenotype, non-enhanceable by l(2)52Fd^E3.27

(Halsell and Kiehart, 1998)

zip^Ebr has phenotype, non-enhanceable by l(2)52Fe^E6.17

(Halsell and Kiehart, 1998)

Suppressed by

Statement

Reference

RhoGEF2⁰⁴²⁹¹, zip^Ebr has wing phenotype, suppressible by Mbs³

(Mizuno et al., 2002)

Rho1^72O, zip^Ebr has wing phenotype, suppressible | partially by Mbs³

(Mizuno et al., 2002)

Rho1^72BH, zip^Ebr has wing phenotype, suppressible by Mbs³

(Mizuno et al., 2002)

zip⁰²⁹⁵⁷/zip^Ebr has wing phenotype, suppressible | partially by Mbs³/Mbs[+]

(Mizuno et al., 2002)

Rok², zip^Ebr has wing phenotype, suppressible by Mbs³

(Mizuno et al., 2002)

Enhancer of

Statement

Reference

zip²/zip^Ebr is an enhancer of embryonic/first instar larval cuticle | embryonic stage phenotype of cno^mis1/cno²

(Boettner and Van Aelst, 2007)

zip²/zip^Ebr is an enhancer of ectoderm | embryonic stage phenotype of cno^mis1/cno²

(Boettner and Van Aelst, 2007)

zip²/zip^Ebr is an enhancer of embryo phenotype of PDZ-GEF^k13720/PDZ-GEF^C2

(Boettner and Van Aelst, 2007)

zip[+]/zip^Ebr is an enhancer of leg phenotype of Sb⁷⁰

(Chen et al., 2004)

zip[+]/zip^Ebr is an enhancer of leg phenotype of br¹

(Chen et al., 2004)

zip[+]/zip^Ebr is an enhancer of leg phenotype of Sb^63b

(Chen et al., 2004)

Other

Statement

Reference

Scer\GAL4^dpp.PU, fwe^{UASp.Lose-A.C.Tag:HA}, zip²/zip^Ebr has anterior-posterior compartment boundary of the wing disc phenotype

(Levayer et al., 2015)

PDZ-GEF^k13720/PDZ-GEF^C2, zip²/zip^Ebr has embryonic/first instar larval cuticle | embryonic stage phenotype

(Boettner and Van Aelst, 2007)

PDZ-GEF^k13720/PDZ-GEF^C2, zip²/zip^Ebr has ectoderm | embryonic stage phenotype

(Boettner and Van Aelst, 2007)

cno^mis1/cno², zip^Ebr has wing phenotype

(Boettner and Van Aelst, 2007)

E(zip)31-6^31-6, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

Sb⁷⁰, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rok², zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

RhoGEF2^4.1, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003, Halsell et al., 2000)

E(zip)18-5^18-5, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rok¹, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

Rok¹, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003, Halsell et al., 2000)

Rok², zip^Ebr has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rho1^12-6, zip^Ebr has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, zip^Ebr has wing phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, zip^Ebr has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, zip^Ebr has wing phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, zip^Ebr has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, zip^Ebr has wing phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, zip^Ebr has leg phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, zip^Ebr has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip^Ebr has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rok¹, zip^Ebr has leg phenotype

(Bayer et al., 2003)

Rok¹, zip^Ebr has wing phenotype

(Bayer et al., 2003)

Sb⁷⁰, zip^Ebr has wing phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, zip^Ebr has leg phenotype

(Bayer et al., 2003, Halsell et al., 2000)

RhoGEF2^1.1, zip^Ebr has leg phenotype

(Bayer et al., 2003, Halsell et al., 2000)

RhoGEF2^4.1, zip^Ebr has leg phenotype

(Bayer et al., 2003, Halsell et al., 2000)

RhoGEF2⁰⁴²⁹¹, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003, Halsell et al., 2000)

Sb^Ebr536, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)65^Ebr65, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)121^Ebr121, zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)160^Ebr160, zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)65^Ebr65, zip^Ebr has leg phenotype

(Ward et al., 2003)

Rho1^Ebr233, zip^Ebr has leg phenotype

(Ward et al., 2003)

Rho1^Ebr246, zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr20, zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr448, zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr48, zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr536, zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr623, zip^Ebr has leg phenotype

(Ward et al., 2003)

Rho1^Ebr233, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)121^Ebr121, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr48, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr448, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr623, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Rho1^Ebr246, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Sb^Ebr20, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)160^Ebr160, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Rho1^72BH, zip^Ebr has wing phenotype

(Mizuno et al., 2002)

Rho1^72BH/Rho1[+], zip^Ebr has wing phenotype

(Mizuno et al., 2002)

Rho1^72O/Rho1[+], zip^Ebr has wing phenotype

(Mizuno et al., 2002)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], zip^Ebr has wing phenotype

(Mizuno et al., 2002)

rok[+]/Rok², zip^Ebr has wing phenotype

(Mizuno et al., 2002)

Rho1^72O, zip^Ebr has wing phenotype

(Mizuno et al., 2002)

RhoGEF2⁰⁴²⁹¹, zip^Ebr has wing phenotype

(Mizuno et al., 2002)

Rok², zip^Ebr has wing phenotype

(Mizuno et al., 2002)

Df(2R)Jp8/+, zip^Ebr has leg phenotype

(Halsell et al., 2000)

RhoGEF2^4.1, zip[+]/zip^Ebr has femur phenotype

(Halsell et al., 2000)

RhoGEF2^4.1, zip[+]/zip^Ebr has tibia phenotype

(Halsell et al., 2000)

RhoGEF2^4.1, zip[+]/zip^Ebr has wing phenotype

(Halsell et al., 2000)

Rho1^J3.8, zip[+]/zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip^Ebr has femur phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip^Ebr has tibia phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip^Ebr has wing phenotype

(Halsell et al., 2000)

Rho1^J3.8, zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^72F, zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^72F, zip^Ebr has wing vein phenotype

(Halsell et al., 2000)

Rho1^72F, zip^Ebr has wing phenotype

(Halsell et al., 2000)

Rho1^72O, zip^Ebr has leg phenotype

(Halsell et al., 2000)

RhoGEF2^4.1, zip^Ebr has femur phenotype

(Halsell et al., 2000)

RhoGEF2^4.1, zip^Ebr has tibia phenotype

(Halsell et al., 2000)

RhoGEF2^4.1, zip^Ebr has wing phenotype

(Halsell et al., 2000)

+/Df(2R)Jp4, zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^72O, zip[+]/zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^72F, zip[+]/zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^72F, zip[+]/zip^Ebr has wing vein phenotype

(Halsell et al., 2000)

Rho1^72F, zip[+]/zip^Ebr has wing phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip[+]/zip^Ebr has femur phenotype

(Halsell et al., 2000, Halsell and Kiehart, 1998)

Rho1^E3.10, zip[+]/zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^E3.10, zip[+]/zip^Ebr has tibia phenotype

(Halsell et al., 2000, Halsell and Kiehart, 1998)

Rho1^E3.10, zip[+]/zip^Ebr has wing phenotype

(Halsell et al., 2000)

vkg⁰¹²⁰⁹, zip[+]/zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3R)ea/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3R)ea/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)JC70/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)JC70/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)RA2/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)RA2/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)v-L15/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)v-L15/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)v-N48/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)v-N48/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)HA85/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)HA85/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)r-D1/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)r-D1/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

vkg^k09511, zip[+]/zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)30A-C/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)30A-C/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)H20/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)H20/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)TW50/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)TW50/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

vkg^k09511, zip[+]/zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

+/In(2R)bw^VDe2LCy^R, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

+/In(2R)bw^VDe2LCy^R, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)nap1/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)nap1/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)Jp1/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)Jp1/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

In(2LR)Px⁴/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

In(2LR)Px⁴/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)W10/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)W10/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)cl-h3/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)cl-h3/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)bw^VDe2LPx^KR/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)bw^VDe2LPx^KR/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)Jp8/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)Jp8/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)81k19/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)81k19/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

+/Df(3L)st4, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

+/Df(3L)st4, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)st7/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)st7/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)st-b11/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)st-b11/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Tm1[+]/Tm1^eg9, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Tm1[+]/Tm1^eg9, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

vkg[+]/vkg⁰¹²⁰⁹, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

vkg[+]/vkg⁰¹²⁰⁹, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

vkg^k09511/vkg[+], zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

vkg^k09511/vkg[+], zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Rho1^E3.10/Rho1[+], zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Rho1^E3.10/Rho1[+], zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8/Rho1[+], zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8/Rho1[+], zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

vkg⁰¹²⁰⁹, zip[+]/zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)64c18/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)64c18/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)A113/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)A113/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

+/Df(1)ct-J4, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

+/Df(1)ct-J4, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Tm1^eg9, zip[+]/zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Tm1^eg9, zip[+]/zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)ct4b1/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)ct4b1/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Tm1^er4, zip[+]/zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Tm1^er4, zip[+]/zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)g/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)g/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)HF396/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)HF396/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)JS32/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)JS32/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)sc19-5/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)sc19-5/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)TE29Aa-11/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)TE29Aa-11/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)J39/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)J39/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2L)osp29/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2L)osp29/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

+/Df(2R)M41A4, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

+/Df(2R)M41A4, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)B5/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)B5/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)vg-C/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)vg-C/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)CX1/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)CX1/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)PC4/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)PC4/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(2R)or-BR6/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(2R)or-BR6/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)M21/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)M21/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)HR370/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)HR370/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)HR119/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)HR119/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)GN24/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)GN24/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)AC1/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)AC1/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)Cat/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)Cat/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)rdgC-co2/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)rdgC-co2/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(3L)Pc-MK/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(3L)Pc-MK/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Df(1)sc-J4/+, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Df(1)sc-J4/+, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

A zip²/zip^Ebr mutant background (which reducing tension in cells) induces cell death at the anterior boundary when fwe^{Scer\UAS.P\T.Lose-A.C.T:Ivir\HA1} is expressed under the control of Scer\GAL4^dpp.PU in the anterior compartment of the wing disc.

(Levayer et al., 2015)

The frequency of the malformed leg phenotype seen in Sb^63b/+ heterozygotes (8%) is increased if the flies are also heterozygous for zip^Ebr (63%). The frequency of the malformed leg phenotype seen in Sb⁷⁰/+ heterozygotes (7%) is increased if the flies are also heterozygous for zip^Ebr (96%). The frequency of the malformed leg phenotype seen in br¹/Y males (1%) is increased if the flies are also heterozygous for zip^Ebr (56%).

(Chen et al., 2004)

zip^Ebr shows no interaction with sqh^unspecified (assayed in terms of a malformed leg phenotype). zip^Ebr shows a strong interaction (at least 50% of double heterozygotes have at least one malformed leg) with the following mutations: RhoGEF2^11-3, E(zip)12-5^12-5 and Rho1^12-6. zip^Ebr shows a moderate interaction (25-49% of double heterozygotes have at least one malformed leg) with the following mutations: E(zip)18-5^18-5. zip^Ebr shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: E(zip)31-6^31-6. zip^Ebr shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: rok¹, Sb⁷⁰, RhoGEF2^11-3, E(zip)12-5^12-5, Rho1^12-6 and E(zip)31-6^31-6. zip^Ebr shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: E(zip)18-5^18-5.

(Bayer et al., 2003)

The fraction of flies showing a malformed leg phenotype in at least one leg, for zip^Ebr in double heterozygous combination with one of the following alleles is - Sb^Ebr20 : 46%, Sb^Ebr48 : 30%, Sb^Ebr228 : 14%, Sb^Ebr448 : 57%, Sb^Ebr536 : 33%, Sb^Ebr623 : 26%, Rho1^Ebr233 : 93%, Rho1^Ebr246 : 83%, bs^Ebr292 : 2%, E(br)24^Ebr24 : 9%, E(br)65^Ebr65 : 67%, E(br)155^Ebr155 : 7%, E(br)165^Ebr165 : 6%, E(br)333^Ebr333 : 4%, E(br)72^Ebr72 : 4%, E(br)121^Ebr121 : 82%, E(br)160^Ebr160 : 20%, E(br)187^Ebr187 : 6%, E(br)420^Ebr420 : 15% and E(br)444^Ebr444 : 84%.

(Ward et al., 2003)

The lethality of Mbs mutant embryos derived from Mbs^EP3727/Df(3L)th117 females mated to Mbs³/+ males is suppressed by zip^Ebr/+.

(Mizuno et al., 2002)

27% of RhoGEF2^4.1/zip^Ebr double heterozygotes have a malformed leg phenotype, which shows variable expressivity. In less severe cases, there is a dent in the femur or tibia. Flies with malformed legs often also show wing defects. Weak phenotypes include a broadening of the wing blade and folding back of the distal portion of the wing blade. In the most severe cases, wings are greatly reduced in size. 38% of RhoGEF2⁰⁴²⁹¹/zip^Ebr double heterozygotes have a malformed leg phenotype. 33% of RhoGEF2^1.1/zip^Ebr double heterozygotes have a malformed leg phenotype. 100% of Rho1^J3.8/zip^Ebr double heterozygotes have a malformed leg phenotype. 100% of Rho1^E3.10/zip^Ebr double heterozygotes have a malformed leg phenotype, which shows variable expressivity. In more severe cases, a dent and twisting of the femur is apparent, along with shortening and thickening of the tibia. Notching of the posterior region of the wing blade is also seen. 96% of Rho1^72F/zip^Ebr double heterozygotes have a malformed leg phenotype. Wing defects are also seen. Weak phenotypes include a broadening of the wing blade and folding back of the distal portion of the wing blade. In more severe cases, wings lacking adhesion between the wing blade bilayer and any apparent wing venation are seen. 92% of Rho1^72O/zip^Ebr double heterozygotes have a malformed leg phenotype. 90% of Df(2R)Jp4/zip^Ebr double heterozygotes have a malformed leg phenotype. 98% of Df(2R)Jp8/zip^Ebr double heterozygotes have a malformed leg phenotype.

(Halsell et al., 2000)

Produces malformed phenotype when in double heterozygosis with second site zip non-complementing mutants. Shows a higher level of penetrance with second site non-complementers than does zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

E(br)¹

(Gotwals and Fristrom, 1991)

zip^E(br)

(Farkas et al., 2007, Ward et al., 2003)

zip^Ebr

(Hawley and Gilliland, 2006)

zip^ebr

(Levayer et al., 2015, Boettner and Van Aelst, 2007, Chen et al., 2004)

zipE(br)

(Farkas et al., 2006, Farkas et al., 2003)

zipEbr

(Swain and Kiehart, 2002)

Name Synonyms

Secondary FlyBase IDs

References (19)

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