FB2020_06, released Dec 22, 2020

Allele: Dmel\beat-Iatric-1

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General Information
Symbol
Dmel\beat-Iatric-1
Species
D. melanogaster
Name
FlyBase ID
FBal0088571
Feature type
allele
Associated gene
Dmel\beat-Ia
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Holmes et al., 1998)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      No mutation in the coding region.

      (Heilig, 1998.10.3)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Motoneuron development is not affected by beat-Iatric-1. Cells of the Bolwig's organs (BOs) form in homozygous embryos, but the morphology of the larval visual system (LVS) is severely disrupted and increased numbers of photoreceptor cells are apparent from the earliest stages of LVS development. Extra photoreceptor cells are seen both in the normal location of the BO clusters and dispersed between the two clusters. Embryos sometimes contain three BO's and, rarely, four BO clusters are seen. Migration of the BOs appears relatively normal in some embryos, but in others it is disrupted and the BO does not achieve its proper location even though head involution appears normal, or the BO is elongated. Larval visual system development occurs normally in 93% of beat-Iatric-1 embryos expressing beat-IaScer\UAS.cFa under the control of Scer\GAL4bi-omb-Gal4. However, a large number of these embryos fail to develop.

      (Holmes and Heilig, 1999)

      In a subset of embryos three distinct Bolwig's organs are seen.

      (Holmes et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      beat-Iatric-1 has Bolwig organ phenotype, suppressible | partially by Fas2e76

      (Holmes and Heilig, 1999)
      Suppressor of
      Statement
      Reference

      beat-Iatric-1 is a suppressor | partially of Bolwig organ phenotype of Fas2e76

      (Holmes and Heilig, 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The defects in development of the LVS seen in both beat-Iatric-1 and Fas2e76 single mutants are partly suppressed in Fas2e76; beat-Iatric-1 double mutants; the LVS develops normally in the majority of double mutant embryos and the defects seen are relatively minor.

      (Holmes and Heilig, 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      beat-Iaunspecified

      (Heilig, 1998.10.3)
      Rescued by

      beat-Iatric-1 is rescued by Scer\GAL4Kr.PM/beat-IaUAS.cFa

      (Holmes and Heilig, 1999)

      beat-Iatric-1 is rescued by beat-IaUAS.cFa/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF

      (Holmes and Heilig, 1999)

      beat-Iatric-1 is rescued by beat-IaUAS.cFa/Scer\GAL4unspecified

      (Heilig, 1998.10.3)
      Partially rescued by

      beat-Iatric-1 is partially rescued by beat-IaUAS.cFa/Scer\GAL4bi-omb-Gal4

      (Holmes and Heilig, 1999)
      Comments

      Mutants have Bolwig organ defects. Motoneurons are unaffected. The Bolwig organ defect is rescued by expression of beat-IaScer\UAS.cFa directed to the Bolwig organs or optic lobes. Fails to complement beat-Iaunspecified when the Bolwig organ phenotype is assessed.

      (Heilig, 1998.10.3)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      beat-Iatric-1
      beattric-1
      beattric
      (Ashburner et al., 1999.10.12, Holmes and Heilig, 1999)
      tric
      (Ashburner et al., 1999, Heilig, 1998.10.3)
      tric-
      (Holmes et al., 1998)
      tric1
      Name Synonyms
      Secondary FlyBase IDs
        References (5)