FlyBase Allele Report: Dmel\trr[1]

General Information

Symbol

Dmel\trr¹

Species

D. melanogaster

Name

FlyBase ID

FBal0096654

Feature type

allele

Associated gene

Dmel\trr

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sedkov et al., 1999)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q89term.

(Sedkov et al., 1999)

Nucleotide substitution: C?T.

(Sedkov et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:1,889,511..1,889,511 [-]

Nucleotide change:

C1889511T

Reported nucleotide change:

C?T

Amino acid change:

Q89term | trr-PC; Q89term | trr-PD

Reported amino acid change:

Q89term

(Sedkov et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Song et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | female | germline clone

(Prudêncio et al., 2018)

female sterile | germline clone

(Prudêncio et al., 2018)

lethal - all die during embryonic stage | recessive

(Sedkov et al., 1999)

non-enhancer of variegation, with In(1)w^m4

(Sedkov et al., 1999)

non-suppressor of variegation, with In(1)w^m4

(Sedkov et al., 1999)

some die during embryonic stage | recessive

(Sedkov et al., 1999)

Phenotype Manifest In

eye | somatic clone

(Sedkov et al., 2003)

eye disc morphogenetic furrow | somatic clone

(Sedkov et al., 2003)

male pronucleus | germline clone | maternal effect

(Prudêncio et al., 2018)

ommatidium | somatic clone

(Sedkov et al., 2003)

polar body nucleus | germline clone

(Prudêncio et al., 2018)

Detailed Description

Statement

Reference

Eggs derived from trr¹ germline clones form eggs that do not enter embryogenesis because they do not initiate embryo mitotic divisions. The eggs do not support male pronucleus formation (and Protamine B is not removed). Meiosis is invariably completed but seems unsuccessful (shown by abnormal polar body rosettes).

(Prudêncio et al., 2018)

Homozygous trr¹ clones in the eye lead to notching of the anterior boundary of the eye presumably caused by incomplete morphogenetic furrow progression, and there are defects in ommatidial organisation leading to a rough eye phenotype.

(Sedkov et al., 2003)

Hemizygous males derived from trr¹/+ females (lack of zygotic trr⁺ activity combined with a 50% reduction in maternal trr⁺ activity) show embryonic lethality. When trr¹ is introduced paternally rather than maternally, the percentage of hemizygous embryos that fail to hatch decreases, and some dead first instar larvae are seen, indicating that trr⁺ activity is required both maternally and zygotically during embryogenesis. trr¹ does not affect the position effect variegation of the w gene caused by In(1)w^m4.

(Sedkov et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

trr¹ is an enhancer of lethal phenotype of EcR^{B1-ΔC655.F645A.UAS}, Scer\GAL4^GMR.PF

(Sedkov et al., 2003)

Phenotype Manifest In

Suppressed by

Statement

Reference

trr¹ has eye disc morphogenetic furrow | somatic clone phenotype, suppressible by EcR^M554fs/EcR[+]

(Sedkov et al., 2003)

trr¹ has eye | somatic clone phenotype, suppressible by EcR^M554fs/EcR[+]

(Sedkov et al., 2003)

Enhancer of

Statement

Reference

trr¹ is an enhancer of eye phenotype of Bar¹, ecd¹

(Sedkov et al., 2003)

trr¹/trr[+] is an enhancer of eye phenotype of dpp^d-blk

(Sedkov et al., 2003)

NOT Enhancer of

Statement

Reference

trr¹ is a non-enhancer of phenotype of trx^B11

(Sedkov et al., 1999)

trr¹ is a non-enhancer of antenna phenotype of Pc³

(Sedkov et al., 1999)

trr¹ is a non-enhancer of leg | ectopic phenotype of Pc³

(Sedkov et al., 1999)

NOT Suppressor of

Statement

Reference

trr¹ is a non-suppressor of antenna phenotype of Pc³

(Sedkov et al., 1999)

trr¹ is a non-suppressor of leg | ectopic phenotype of Pc³

(Sedkov et al., 1999)

trr¹ is a non-suppressor of phenotype of trx^B11

(Sedkov et al., 1999)

Other

Statement

Reference

hh⁸, trr¹ has eye phenotype

(Sedkov et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

In animals that are homozygous for ecd¹ and are also B¹ the addition of trr¹ enhances the eye phenotype.

(Sedkov et al., 2003)

The lethality seen in EcR^{B1-ΔC655.F645A.Scer\UAS}, Scer\GAL4^GMR.PF animals is enhanced by the addition of trr¹/+. The furrow stop phenotype (in the eye) is noticeably suppressed by the addition of EcR^M554fs/+.

(Sedkov et al., 2003)

34.4% of Pc³/+ males show transformation of antenna to leg. trr¹ neither enhances nor suppresses this phenotype. trr¹ neither enhances nor suppresses trx^B11 adult homeotic phenotypes.

(Sedkov et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

trr⁴

(Sedkov et al., 2003)

Rescued by

trr¹ is rescued by trr^+t12

(Sedkov et al., 1999)

Not rescued by

trr¹ is not rescued by trr^t8

(Sedkov et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

94152

y¹ trr¹ w^* P{πM}10D P{neoFRT}18A/FM7c

94151

y¹ trr¹ w^* P{neoFRT}19A/FM7i, P{ActGFP}JMR3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

trr¹

(Gandara et al., 2022, Rickels et al., 2020, Prudêncio et al., 2018, Song et al., 2018, Hallson et al., 2012, Herz et al., 2012, Johnston et al., 2011)

trr[1]

(Rickels et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

Open Close