FlyBase Allele Report: Dmel\Pten[c494]

General Information

Symbol

Dmel\Pten^c494

Species

D. melanogaster

Name

FlyBase ID

FBal0102915

Feature type

allele

Associated gene

Dmel\Pten

Associated Insertion(s)

Carried in Construct

Also Known As

dPTEN^c494

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Huang et al., 1999)

Mutagen

ethyl methanesulfonate

(Huang et al., 1999)

Progenitor genotype

Cytology

Description

Amino acid replacement: G135E. G135 is an invariant residue in the active site motif of the catalytic domain, required for phosphatase activity.

(Huang et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:10,259,043..10,259,043 [-]

Nucleotide change:

G10259043A

Amino acid change:

Reported amino acid change:

G135E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Huang et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | pupal stage | somatic clone

(Wong et al., 2013)

abnormal size | somatic clone

(Huang et al., 1999)

increased cell size | somatic clone

(Huang et al., 1999)

lethal | recessive

(Huang et al., 1999)

visible | somatic clone

(Huang et al., 1999)

Phenotype Manifest In

abdominal tracheal primordium 1 | germline clone | maternal effect

(Jin et al., 2001)

abdominal tracheal primordium 2 | germline clone | maternal effect

(Jin et al., 2001)

egg | maternal effect

(von Stein et al., 2005)

interommatidial bristle | P-stage

(Malin et al., 2024)

interommatidial cell | P-stage

(Malin et al., 2024)

larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone

(Wong et al., 2013)

mesothoracic tracheal primordium | germline clone | maternal effect

(Jin et al., 2001)

metathoracic tracheal primordium | germline clone | maternal effect

(Jin et al., 2001)

ommatidium | P-stage

(Malin et al., 2024)

ommatidium | somatic clone

(Huang et al., 1999)

photoreceptor neuron | somatic clone

(Huang et al., 1999)

tertiary pigment cell | P-stage

(Malin et al., 2024)

tracheal primordium | ectopic | germline clone | maternal effect

(Jin et al., 2001)

tracheal primordium | germline clone | maternal effect

(Jin et al., 2001)

Detailed Description

Statement

Reference

Pten^c494 mutant ddaC neuron clones exhibit dendrite pruning defects at 16 hours after puparium formation. No difference is seen in white prepupae.

(Wong et al., 2013)

Eggs derived from females carrying homozygous germline clones are generally smaller than wild type.

(von Stein et al., 2005)

Embryos laid by mothers carrying Pten^c494 germ-line clones have expanded tracheal primordia (placodes) at stage 11. The thoracic tracheal primordia and abdominal primordia 1 and 2 are most affected. Ectopic tracheal placodes are also sometimes present.

(Jin et al., 2001)

Lethality acts at the late embryonic/early first larval instar phase. Clones induced in the eye have ommatidia that are larger than their wild type neighbors. Photoreceptor cell composition and orientation are normal. Individual mutant cells are larger than wild type. The mutant phenotype is cell autonomous. No overproliferation defect occurs.

(Huang et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Pten^c494/Pten[+] is a non-enhancer of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

NOT Suppressor of

Statement

Reference

Pten^c494/Pten[+] is a non-suppressor of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Other

Statement

Reference

Pdk1⁵/Pdk1⁴, Pten^dj189/Pten^c494 has viable phenotype

(Rintelen et al., 2001)

Pdk1⁵/Pdk1⁴, Pten^dj189/Pten^c494 has visible phenotype

(Rintelen et al., 2001)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Pten^c494/Pten[+] is a non-enhancer of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Pten^c494/Pten[+] is a non-enhancer of wing phenotype of pyd^tam/pyd^ex147

(Djiane et al., 2011)

NOT Suppressor of

Statement

Reference

Pten^c494/Pten[+] is a non-suppressor of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Other

Statement

Reference

Pdk1⁵/Pdk1⁴, Pten^dj189/Pten^c494 has leg phenotype

(Rintelen et al., 2001)

Pdk1⁵/Pdk1⁴, Pten^dj189/Pten^c494 has adult abdomen phenotype

(Rintelen et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype observed in adults expressing Magi^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PU is not modified by combination with single copy of Pten^c494.

(Zaessinger et al., 2015)

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings, and this phenotype is not modified in a Pten^c494/+ background.

(Djiane et al., 2011)

Pten^dj189/Pten^c494 ; Pk61C⁴/Pk61C⁵ animals can survive to adulthood, although the abdomen is unproportionally reduced in size and leg structures are deformed.

(Rintelen et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pten^c494 is rescued by Pten^+t6.2

(Huang et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

DPTEN^c494

(Potter et al., 2000)

PTEN^C494

(Rambur et al., 2020, Devergne et al., 2014, Wong et al., 2013)

PTEN^c494

(Wong et al., 2013)

Pten^c494

(Djiane et al., 2011)

dPTEN^CX94

(Jin et al., 2001)

dPTEN^c494

(Rintelen et al., 2001, Huang et al., 1999)

pten^C494

(Zaessinger et al., 2015)

pten^c494

(Malin et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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