FlyBase Allele Report: Dmel\scrib[1]

General Information

Symbol

Dmel\scrib¹

Species

D. melanogaster

Name

FlyBase ID

FBal0103577

Feature type

allele

Associated gene

Dmel\scrib

Associated Insertion(s)

Carried in Construct

Also Known As

scrb¹, scribble¹

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Bilder and Perrimon, 2000)

Mutagen

ethyl methanesulfonate

(Zeitler et al., 2004, Bilder and Perrimon, 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Zheng et al., 2023, Kong et al., 2022, Kong et al., 2021, Parvy et al., 2019, Katsukawa et al., 2018, O'Keefe et al., 2015, Igaki et al., 2009, Uhlirova et al., 2005, Brumby and Richardson, 2003, Bilder et al., 2000)

CEA with scrib⁶⁷³

(de Vreede et al., 2022)

CEC

(Rosen et al., 2019)

CEC with Ras85D^V12.UAS

(Rosen et al., 2019)

CEA with Ras85D^V12.UAS

(Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

CEA with Raf^UAS.F179

(Wei et al., 2021, Uhlirova et al., 2005)

CEA with egr¹

(Igaki et al., 2009)

CEA with Rab5^S43N.UAS

(Igaki et al., 2009)

model of cancer

CEA with Ras85D^V12.UAS

(Kakemura and Igaki, 2024, Cong et al., 2021, Hodgson et al., 2021, Külshammer et al., 2015, Stickel and Su, 2014, Külshammer and Uhlirova, 2013, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)

CEA with cno^R2

(Rives-Quinto et al., 2017)

CEA

(Cao et al., 2022, Sanaki et al., 2020, Bunker et al., 2015, Ohsawa et al., 2011)

CEA with rl^R80S.UAS

(Kushnir et al., 2020)

CEA with rl^{D334N.UAS.cKa}

(Kushnir et al., 2020)

CEA with rl^{R80S.D334N.UAS}

(Kushnir et al., 2020)

CEA with Ras85D^V12.QUAS.cHa

(Hodgson et al., 2021)

CEA with Ras85D^V12.cUa.UAS

(Yang et al., 2022, Khezri et al., 2021)

CEA with wts^x1

(Cao et al., 2022)

CEA with Raf^UAS.F179

(Yang et al., 2022)

model of benign neoplasm

CEA

(de Vreede et al., 2018)

model of kidney cancer

CEA

(Zeng et al., 2010)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of carcinoma

is exacerbated by Toll-6^GD35

(Kong et al., 2022)

is exacerbated by α-Spec^HMC04371

(Kong et al., 2022)

is exacerbated by Rho1^72F

(Kong et al., 2022)

is exacerbated by Rok^GD1522

(Kong et al., 2022)

is exacerbated by Toll-6^GD14438

(Kong et al., 2022)

is exacerbated by kst^GLC01654

(Kong et al., 2022)

is exacerbated by sqh^GL00663

(Kong et al., 2022)

is exacerbated by zip^GD1566

(Kong et al., 2022)

is ameliorated by HAdV-C\E4orf4^UAS.cPa

(Rosen et al., 2019)

is ameliorated by HAdV-C\E4orf4^UAS.cPb

(Rosen et al., 2019)

is exacerbated by BacA\p35^UAS.cHa

(Zheng et al., 2023, Brumby and Richardson, 2003)

is ameliorated by Dad^UAS.cTa

(Brumby and Richardson, 2003)

is ameliorated by Egfr^DN.UAS

(Brumby and Richardson, 2003)

is exacerbated by N^ICN.UAS

(Brumby and Richardson, 2003)

is exacerbated by Ras85D^V12.UAS

(Brumby and Richardson, 2003)

is exacerbated by bsk^K53R.UAS

(Uhlirova et al., 2005, Brumby and Richardson, 2003)

is ameliorated by pan^ΔN.UAS

(Brumby and Richardson, 2003)

is ameliorated by Wwox^KK108459

(O'Keefe et al., 2015)

is exacerbated by dl^UAS.cHa

(Katsukawa et al., 2018)

is exacerbated by Dif^LA00958

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^GD12724

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^HMS01371

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^c01214

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^eld5

(Katsukawa et al., 2018)

is exacerbated by Tl^10b.UAS

(Katsukawa et al., 2018)

is ameliorated by hep^Act.UAS

(Uhlirova et al., 2005)

is ameliorated by kay^RNAi.UAS

(Uhlirova and Bohmann, 2006)

is ameliorated by puc^UAS.cMa

(Uhlirova and Bohmann, 2006)

is exacerbated by Def^SK3

(Parvy et al., 2019)

is exacerbated by egr³

(Parvy et al., 2019)

is exacerbated by bsk^DN.UAS.cUa

(Kong et al., 2021)

is ameliorated by msn^UAS.cSa

(Kong et al., 2021)

is ameliorated by Diap1^UAS.cHa

(Zheng et al., 2023)

is ameliorated by Dronc^DN.UAS.cUa

(Zheng et al., 2023)

is ameliorated by Ire1^GD3071

(Zheng et al., 2023)

is ameliorated by Ire1^f02170

(Zheng et al., 2023)

is ameliorated by Xbp1^GD4745

(Zheng et al., 2023)

is ameliorated by Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

is exacerbated by bsk^DN.UAS

(Zheng et al., 2023)

model of cancer

is ameliorated by hep^r75

(Bunker et al., 2015)

is ameliorated by yki^B5

(Bunker et al., 2015)

is ameliorated by egr¹

(Ohsawa et al., 2011)

is ameliorated by Ilp2¹

(Sanaki et al., 2020)

is exacerbated by Ilp2^UAS.cBa

(Sanaki et al., 2020)

is ameliorated by Ilp5³

(Sanaki et al., 2020)

is ameliorated by InR^K1409A.UAS

(Sanaki et al., 2020)

is exacerbated by InR^UAS.Exel

(Sanaki et al., 2020)

is exacerbated by chico¹

(Sanaki et al., 2020)

is exacerbated by chico^KK107581

(Sanaki et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Clonal expression of Ras85D^V12.UAS in a scrib¹ background results in malignant tumors that display the main hallmarks of human metastatic cancers.

(Mishra-Gorur et al., 2019)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell growth | somatic clone

(Igaki et al., 2006)

abnormal cell polarity | larval stage

(de Vreede et al., 2018)

abnormal cell polarity | somatic clone

(Zeng et al., 2010, Igaki et al., 2006)

abnormal memory | dominant

(Cervantes-Sandoval et al., 2016)

abnormal neuroanatomy

(Roche et al., 2002)

abnormal neuroanatomy | somatic clone | third instar larval stage

(Rives-Quinto et al., 2017)

abnormal planar polarity | larval stage (with scrib^j7B3)

(Dow et al., 2003)

abnormal planar polarity | somatic clone

(Dow et al., 2003)

abnormal size | larval stage (with scrib⁶⁷³)

(Zeitler et al., 2004)

abnormal size | somatic clone | third instar larval stage

(Rives-Quinto et al., 2017)

abnormal size | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

abnormal smell perception | adult stage (with scrib^smi97B)

(Ganguly et al., 2003)

cell lethal | somatic clone

(Wu et al., 2010, Brumby and Richardson, 2003)

decreased cell number | larval stage | somatic clone

(Zheng et al., 2023, Brumby and Richardson, 2003)

decreased cell number | somatic clone | third instar larval stage

(Rives-Quinto et al., 2017)

decreased occurrence of cell division | somatic clone

(Igaki et al., 2006)

decreased size | larval stage | somatic clone - tissue specific

(Kong et al., 2021)

female fertile | germline clone

(Lighthouse et al., 2008)

hyperplasia

(Wu et al., 2010)

hyperplasia | recessive

(Bilder et al., 2000)

increased body size | third instar larval stage (with Df(3R)Tl-X)

(Zeitler et al., 2004)

increased body size | third instar larval stage (with scrib⁶⁷³)

(Zeitler et al., 2004)

increased body size | third instar larval stage (with scrib^ird15)

(Zeitler et al., 2004)

increased cell death | larval stage

(Parvy et al., 2019)

increased cell death | larval stage | somatic clone

(Zheng et al., 2023, Brumby and Richardson, 2003)

increased cell death | somatic clone

(Uhlirova et al., 2005, Brumby and Richardson, 2003)

increased cell death | somatic clone | third instar larval stage

(Khoo et al., 2013)

increased cell number | larval stage

(Parisi et al., 2014)

increased cell number | somatic clone

(Zeng et al., 2010)

increased occurrence of cell division | adult stage | somatic clone

(Zeng et al., 2010)

increased occurrence of cell division | larval stage | somatic clone

(Brumby and Richardson, 2003)

lethal | recessive

(Lighthouse et al., 2008)

lethal - all die before end of larval stage (with Df(3R)Tl-X)

(Zeitler et al., 2004)

lethal - all die before end of larval stage (with scrib⁶⁷³)

(Zeitler et al., 2004)

lethal - all die before end of larval stage (with scrib^ird15)

(Zeitler et al., 2004)

lethal - all die before end of larval stage (with scrib^j7B3)

(Dow et al., 2003)

lethal - all die before end of P-stage (with scrib⁸⁸²)

(Zeitler et al., 2004)

lethal - all die before end of P-stage | somatic clone

(Zeitler et al., 2004)

lethal - all die before end of pupal stage (with scrib^dt6)

(Zeitler et al., 2004)

lethal - all die before end of pupal stage (with scrib^dt12)

(Zeitler et al., 2004)

melanotic necrosis | adult stage | somatic clone

(Zheng et al., 2023)

neoplasia | adult stage | somatic clone

(Hwangbo et al., 2016)

neoplasia | larval stage

(Parvy et al., 2019, de Vreede et al., 2018)

neoplasia | larval stage | somatic clone

(Uhlirova et al., 2005)

neoplasia | somatic clone

(Uhlirova and Bohmann, 2006)

neoplasia | third instar larval stage

(Bunker et al., 2015)

partially lethal - majority die | somatic clone

(Ohsawa et al., 2011)

some die during larval stage (with scrib^j7B3)

(Dow et al., 2003)

some die during pharate adult stage (with scrib⁸⁸²)

(Zeitler et al., 2004)

some die during pharate adult stage | somatic clone

(Zeitler et al., 2004)

some die during pupal stage (with scrib^dt6)

(Zeitler et al., 2004)

some die during pupal stage (with scrib^dt12)

(Zeitler et al., 2004)

some die during pupal stage | somatic clone

(Ohsawa et al., 2011)

some die during third instar larval stage (with Df(3R)Tl-X)

(Zeitler et al., 2004)

some die during third instar larval stage (with scrib⁶⁷³)

(Zeitler et al., 2004)

some die during third instar larval stage (with scrib^ird15)

(Zeitler et al., 2004)

viable (with scrib⁵)

(Brumby et al., 2004)

visible (with scrib⁵)

(Brumby et al., 2004)

Phenotype Manifest In

adherens junction (with scrib⁶⁷³)

(Zeitler et al., 2004)

adult head | somatic clone

(Zeitler et al., 2004)

adult Malpighian tubule | somatic clone

(Zeng et al., 2010)

adult thorax (with scrib⁵)

(Brumby et al., 2004)

antennal disc | somatic clone | third instar larval stage

(Rives-Quinto et al., 2017)

autophagosome | increased number | larval stage | somatic clone

(Zheng et al., 2023)

chaeta (with scrib⁵)

(Brumby et al., 2004)

embryonic/larval hemocyte | larval stage

(Parisi et al., 2014)

epithelial cell

(Dow et al., 2003)

eye

(Hwangbo et al., 2016)

eye (with scrib⁵)

(Brumby et al., 2004)

eye | somatic clone

(Zheng et al., 2023, Uhlirova et al., 2005, Brumby and Richardson, 2003)

eye-antennal disc | somatic clone

(Zheng et al., 2023, Igaki et al., 2009, Uhlirova and Bohmann, 2006)

eye-antennal disc | somatic clone | third instar larval stage

(Khoo et al., 2013)

eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

eye disc | somatic clone

(Wu et al., 2010, Dow et al., 2003)

eye disc | somatic clone - tissue specific

(Kong et al., 2021)

imaginal disc

(Bilder et al., 2000)

lamina

(Roche et al., 2002)

larval brain

(Bilder et al., 2000)

larval brain | somatic clone | third instar larval stage

(Rives-Quinto et al., 2017)

medulla anlage

(Bilder et al., 2000)

neuroblast | embryonic stage

(Albertson et al., 2004)

ommatidium | cell non-autonomous | somatic clone

(Brumby and Richardson, 2003)

ommatidium | somatic clone

(Brumby and Richardson, 2003)

organism | third instar larval stage (with scrib^j7B3)

(Dow et al., 2003)

photoreceptor neuron | somatic clone

(Dow et al., 2003)

septate junction (with scrib⁶⁷³)

(Zeitler et al., 2004)

type II neuroblast | somatic clone | third instar larval stage

(Rives-Quinto et al., 2017)

wing disc

(Parvy et al., 2019, de Vreede et al., 2018, Parisi et al., 2014, Wu et al., 2010)

wing disc (with scrib⁶⁷³)

(Zeitler et al., 2004)

wing disc | somatic clone | third instar larval stage

(Igaki et al., 2009)

wing disc | third instar larval stage

(Bunker et al., 2015)

wing disc | third instar larval stage (with scrib^j7B3)

(Dow et al., 2003)

Detailed Description

Statement

Reference

Eye disc-specific scrib¹ clones are smaller than control clones.

(Kong et al., 2021)

scrib¹ larval wing discs exhibit tumors, and obvious apoptosis (Dcp1 staining).

(Parvy et al., 2019)

The wing discs of scrib¹ mutant larvae present tumors, which are formed of cells with severe polarity defects, as compared to controls.

(de Vreede et al., 2018)

scrib¹ mutant MARCM clones induced in the eye-antennal disc are significantly smaller compared to control clones in third instar larvae.

(Ma et al., 2017)

Type II neuroblast lineage MARCM clones mutant for scrib¹ are harder to recover than control wild-type clones in third instar larvae and frequently very small. The asymmetric localization of major asymmetric cell division regulators in metaphase/anaphase NBs frequently fails in the mutant clones. scrib¹ clones in the antennal imaginal discs occasionally overgrow.

(Rives-Quinto et al., 2017)

scrib¹/+ flies exhibit enhanced memory after conditioning in an olfactory conditioning assay, as compared to controls.

(Cervantes-Sandoval et al., 2016)

scrib¹/scrib¹ mutant eye clones show a tumor-like overgrowth phenotype.

(Hwangbo et al., 2016)

scrib¹ homozygosity leads to the formation of large tumors in the third instar larval wing disc.

(Bunker et al., 2015)

:scrib¹ mutant larvae display a severe increase in the density of circulating hemocytes, as compared to controls.

(Parisi et al., 2014)

scrib¹/scrib¹ mutant clones in the eye-antennal disc are smaller than wild type clones due to increased cell death.

(Khoo et al., 2013)

Induction of homozygous clones in the eye-antennal disc results in approximately 10% pupal lethality.

Homozygous clones induced in the eye-antennal disc are eliminated when surrounded by wild-type cells. Dying cells within these clones are largely restricted to boundaries between mutant and wild-type populations (87.2% of dying cells). Most of these dying cells are seen to be detached from their clones and incorporated into the neighbouring wild-type population. A significant number of the mutant cells are fragmented after incorporation into the wild-type population and they appear to be completely internalised into the wild-type cells.

(Ohsawa et al., 2011)

scrib¹ mutant eye-antennal disc clones lose apical-basal polarity and die. scrib¹ mutant cells are mostly absent from the adult eye and the eye appears normal in size.

The wing discs in scrib¹ mutant larvae are overgrown.

(Wu et al., 2010)

scrib¹ mutant adult Malpighian tubule clones are significantly enlarged compared to wild-type clones. The mitotic index is increased compared to controls. Mutant clusters typically contain proportionally more renal and nephric stem cells (RNSCs) and renablasts (RBs) compared to control clones. Disrupted cell polarity is observed in mutant cells.

(Zeng et al., 2010)

scrib¹ clones generated in developing wing discs are completely eliminated by adulthood, and the wing maintains tissue integrity.

scrib¹ clones generated in the developing eye-antennal disc are eliminated during development, but a small number of mutant clones do survive into adulthood.

(Igaki et al., 2009)

Females carrying homozygous germline clones are fertile.

Homozygous clones in the adult germ cells do not result in defects in the fusome.

(Lighthouse et al., 2008)

Clones of cells mutant for scrib¹ do not proliferate as well as wild-type cells but exhibit a cell polarity defect.

(Igaki et al., 2006)

Clones of scrib¹ eye/antennal imaginal disc cells give rise to a mild tumor phenotype with no detectable invasiveness.

(Uhlirova and Bohmann, 2006)

Only 65% of homozygous stage 15 telophase neuroblasts divide asymmetrically.

(Albertson et al., 2004)

scrib¹/scrib⁵ adults show defects in thorax closure.

(Brumby et al., 2004)

scrib¹/scrib⁶⁷³ transheterozygous wing discs show a dramatic increase in both the surface area and volume compared to wild type.

Animals with eyes homozygous for scrib¹ never eclose, instead dying as headless pharate adults.

Adherens junctions are mislocalized and septate junctions are absent in scrib¹/scrib⁶⁷³ transheterozygous wing discs.

(Zeitler et al., 2004)

Neuroblasts in homozygous stage 15 embryos (lacking zygotic scrib function) show defects in division; 65% undergo normal division, 31% undergo a symmetrical division and 4% undergo an inverted asymmetrical division. Neuroblasts in stage 15 embryos derived from germline clones (lacking both maternal and zygotic scrib function) show defects in division; 74% undergo normal division, 22% undergo a symmetrical division and 4% undergo an inverted asymmetrical division.

(Albertson and Doe, 2003)

When mutant somatic clones are made in the eye disc, the mutant cells lose their monolayered and columnar shape to become rounded and multilayered. Many (but not all) mutant cells are defective in their ability to initiate differentiation. The regular spacing of ommatidia in the tissue immediately surrounding clones is also often disrupted. Ectopic DNA replication and mitoses are also seen. Little mutant tissue survives to become part of the adult eye. There are often signs of necrosis, especially in the middle of the eye. Increased apoptosis is seen in the third instar larval eye.

(Brumby and Richardson, 2003)

scrib¹ clonal patches in the eye disc (generated using MARCM) exhibit disrupted differentiation of photoreceptor cells.

In scrib¹ mutant clones, the columnar, monolayered epithelial cells become rounded and multilayered, suggesting the cells have lost apical-basal polarity.

Less than 9% of scrib¹/scrib^j7B3 mutant larvae survive to pupation.

At the third instar stage of larval development, scrib¹/scrib^j7B3 mutants fail to pupate and continue to grow to form giant larvae. The third instar imaginal wings taken from scrib¹/scrib^j7B3 mutants show loss of monolayered structure and growth in three dimensions.

(Dow et al., 2003)

scrib^smi97B/scrib¹ adults show a significantly lower avoidance response to benzaldehyde compared to controls.

(Ganguly et al., 2003)

Homozygous clones in the eye disc grow poorly and do not invade other tissues. The basement membrane is smooth and continuous on the outer surface of eye discs containing homozygous clones. Marked clones in scrib¹/Df(3R)Tl-X eye discs grow poorly and do not invade other tissues.

(Pagliarini and Xu, 2003)

scrib¹ mutants exhibit a statistically significant increase in synaptic basal lamina thickness compared to wild-type.

(Roche et al., 2002)

Imaginal discs of late third instar homozygous larvae are profoundly disorganised and massively overgrown, containing 4.7 times as many cells as wild-type discs. The discs consist of spherical masses of tightly packed cells as opposed to the folded monolayer epithelium seen in wild-type larvae. Overgrowth of brain tissue is also seen; the brain lobes are much larger than normal and the axon-rich medulla is disorganised.

(Bilder et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

scrib¹ has increased cell death | adult stage | somatic clone phenotype, enhanceable by Ire1^UAS.Tag:V5/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^D231S.UAS

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^GD6484

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^UAS.cEa

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^{UAS.ORF.Tag:HA}

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/SERCA^KK107371

(Zheng et al., 2023)

scrib¹ has increased cell death | larval stage | somatic clone phenotype, enhanceable by Ire1^f02170/Ire1^f02170

(Zheng et al., 2023)

scrib¹ has increased cell death | larval stage | somatic clone phenotype, enhanceable by Ire1^UAS.Tag:V5/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has increased cell death | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Xbp1^GD4745

(Zheng et al., 2023)

scrib¹ has increased cell death | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Ire1^f02170/Ire1^f02170

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Ire1^UAS.Tag:V5/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Xbp1^GD4745

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/PEK^UAS.cMa

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Ire1^GD3071

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Ire1^HMC05163

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Ire1^HMS03003

(Zheng et al., 2023)

scrib¹ has decreased size | larval stage | somatic clone - tissue specific phenotype, enhanceable by Scer\GAL4^Act5C.PI/msn^UAS.cSa

(Kong et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has neoplasia | larval stage | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has increased mortality during development | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

scrib¹ has neoplasia | larval stage phenotype, enhanceable by Def^SK3

(Parvy et al., 2019)

scrib¹ has neoplasia | adult stage | somatic clone phenotype, enhanceable by DCAF12^Δ1

(Hwangbo et al., 2016)

scrib¹ has partially lethal - majority die | pupal stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/egr^RNAi.UAS

(Ohsawa et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, enhanceable by Timp^UAS.cPa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

scrib¹ has neoplasia | somatic clone phenotype, enhanceable by Ras85D^V12.UAS/Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

scrib¹ has neoplasia | somatic clone phenotype, enhanceable by Scer\GAL4^Act5C.PI/kay^RNAi.UAS

(Uhlirova and Bohmann, 2006)

scrib¹ has neoplasia | larval stage | somatic clone phenotype, enhanceable by Scer\GAL4^Act5C.PI/bsk^K53R.UAS

(Uhlirova et al., 2005)

NOT Enhanced by

Statement

Reference

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act.PU/Atf6^VSH330216

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act.PU/crc^KK111018

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, non-enhanceable by crc^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has decreased cell number | larval stage | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act.PU/PEK^GD5584

(Zheng et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^Act.PU, Xbp1^GD4745, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Scer\GAL4^Act.PU, Xbp1^UAS.s.Tag:V5, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Scer\GAL4^Act.PU, Xbp1^UAS.s.Tag:V5, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible | partially by bsk^DN.UAS/Scer\GAL4^Act.PU

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has decreased cell number | somatic clone | adult stage phenotype, suppressible | partially by Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has decreased cell number | somatic clone | adult stage phenotype, suppressible | partially by Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has increased cell death | somatic clone | larval stage phenotype, suppressible | partially by Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has increased cell death | somatic clone | larval stage phenotype, suppressible | partially by Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS, Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS, Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Diap1^UAS.cHa

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Dronc^DN.UAS.cUa

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^Act.PU/BacA\p35^UAS.cHa

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Diap1^UAS.cHa

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Dronc^DN.UAS.cUa

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has melanotic necrosis | somatic clone | adult stage phenotype, suppressible | partially by Ire1^f02170/Ire1^f02170

(Zheng et al., 2023)

scrib¹ has melanotic necrosis | somatic clone | adult stage phenotype, suppressible | partially by Ire1^UAS.Tag:V5/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has melanotic necrosis | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Xbp1^GD4745

(Zheng et al., 2023)

scrib¹ has melanotic necrosis | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^Act.PU/BacA\p35^UAS.cHa

(Zheng et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by JhI-21^HMS02271, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by JhI-21^KK112996, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone phenotype, suppressible by JhI-21^HMS02271, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, scrib¹ has increased size | larval stage | somatic clone - tissue specific phenotype, suppressible | partially by Scer\GAL4^Act5C.PI/msn^UAS.cSa

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has increased size | larval stage | somatic clone - tissue specific phenotype, suppressible by msn^UAS.cSa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has increased mortality during development | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has increased mortality during development | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

scrib¹ has increased cell death | larval stage phenotype, suppressible by Def^SK3

(Parvy et al., 2019)

Scer\GAL4^FRT.Act5C, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | partially | somatic clone by fmt^UAS.cMa/Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

cno^R2, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Ras85D^KK108029/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Ras85D^KK108029/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Ras85D^KK108029/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has increased cell number | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Ras85D^KK108029/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has increased cell number | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Akt^KK100495

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Akt^KK100495

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Akt^KK100495

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has increased cell number | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Akt^KK100495

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Scer\GAL4^Dll-md23/Mmmm\ras^N17.UAS

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Mmmm\ras^N17.UAS

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Mmmm\ras^N17.UAS

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has increased cell number | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Mmmm\ras^N17.UAS

(Rives-Quinto et al., 2017)

scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

scrib¹ has decreased cell number | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

scrib¹ has neoplasia | somatic clone | adult stage phenotype, suppressible by DCAF12^UAS.cHa

(Hwangbo et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹ has neoplasia phenotype, suppressible by grnd^KK109939, Scer\GAL4^Act5C.PP

(Andersen et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹ has neoplasia phenotype, suppressible by egr¹/egr³

(Andersen et al., 2015)

scrib¹ has neoplasia | third instar larval stage phenotype, suppressible by hep^r75

(Bunker et al., 2015)

scrib¹ has neoplasia | third instar larval stage phenotype, suppressible by yki^B5

(Bunker et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay³, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

scrib¹ has increased cell number | larval stage phenotype, suppressible by egr³/egr³

(Parisi et al., 2014)

scrib¹ has increased cell death | somatic clone | third instar larval stage phenotype, suppressible by egr¹/egr³

(Khoo et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype, suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype, suppressible by cher¹

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype, suppressible by zip^GD1566, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has neoplasia | somatic clone phenotype, suppressible by zip^GD1566, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has lethal - all die during third instar larval stage phenotype, suppressible | partially by cher¹

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Ctps^GD4740, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Glts^GD14285, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by bur^GD13797, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by r^GD9607, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Pfas^GD1356, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Gfat1^GD7732, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Prat^GD9838, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Prat2^GD16167, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Nadsyn^GD14730, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Stat92E⁰⁶³⁴⁶, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

scrib¹ has hyperplasia phenotype, suppressible by hep^r75

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by dome^ΔCYT.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

scrib¹ has increased cell death | somatic clone | third instar larval stage phenotype, suppressible by egr¹

(Igaki et al., 2009)

egr¹, scrib¹ has hyperplasia | somatic clone | pupal stage phenotype, suppressible by egr^UAS.cIa/Scer\GAL4^Act5C.PI

(Igaki et al., 2009)

egr¹, scrib¹ has lethal | somatic clone | pupal stage phenotype, suppressible by egr^UAS.cIa/Scer\GAL4^Act5C.PI

(Igaki et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially by Mmp1^Q273/Mmp1^Q273

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Timp^UAS.cSa/Reck^UAS.cSa, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Akt¹

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Akt¹

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | third instar larval stage phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

scrib¹ has increased cell death | somatic clone phenotype, suppressible by Scer\GAL4^Act5C.PI/bsk^K53R.UAS

(Uhlirova et al., 2005)

Raf^UAS.F179, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | larval stage phenotype, suppressible by hep^Act.UAS, Scer\GAL4^Act5C.PI

(Uhlirova et al., 2005)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by dap^UAS.cdNa, Scer\GAL4^αTub84B.PL

(Brumby and Richardson, 2003)

scrib¹ has cell lethal | somatic clone phenotype, suppressible by l(3)cl-R3¹

(Brumby and Richardson, 2003)

scrib¹ has cell lethal | somatic clone phenotype, suppressible by CycE^UAS.cRa/Scer\GAL4^αTub84B.PL/BacA\p35^UAS.cHa

(Brumby and Richardson, 2003)

scrib¹ has cell lethal | somatic clone phenotype, suppressible by Scer\GAL4^αTub84B.PL/BacA\p35^UAS.cHa

(Brumby and Richardson, 2003)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^αTub84B.PL/bsk^K53R.UAS

(Brumby and Richardson, 2003)

scrib¹ has increased cell death | somatic clone | larval stage phenotype, suppressible by l(3)cl-R3¹

(Brumby and Richardson, 2003)

scrib¹ has increased cell death | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^αTub84B.PL/BacA\p35^UAS.cHa

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone phenotype, suppressible by E2f1⁹¹

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by E2f1⁹¹

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone phenotype, suppressible by dap^UAS.cdNa

(Brumby and Richardson, 2003)

scrib¹/scrib^j7B3 has lethal | larval stage phenotype, suppressible by Scer\GAL4^Act.PU/Hsap\SCRIB^UAS.EGFP

(Dow et al., 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible by shg^UAS.cOa, Scer\GAL4^Act5C.PI

(Pagliarini and Xu, 2003)

NOT suppressed by

Statement

Reference

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, non-suppressible by Scer\GAL4^Act.PU/Atf6^VSH330216

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, non-suppressible by Scer\GAL4^Act.PU/crc^KK111018

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, non-suppressible by crc^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, non-suppressible by Scer\GAL4^Act.PU/PEK^GD5584

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, non-suppressible by Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

scrib¹ has decreased cell number | somatic clone | larval stage phenotype, non-suppressible by Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

scrib¹ has increased cell death | somatic clone | adult stage phenotype, non-suppressible by Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

scrib¹ has increased cell death | somatic clone | adult stage phenotype, non-suppressible by Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

cno^R2, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has increased cell number | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by Raf^KK100982/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by Raf^KK100982/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by Raf^KK100982/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has increased cell number | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by Raf^KK100982/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal mitotic cell cycle | somatic clone phenotype, non-suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by Mmp1^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

scrib¹ has cell lethal | somatic clone phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Pi3K92E^UAS.Tag:MYC

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by shg^{i.UAS.Tag:SS(aos),Tag:MYC}, Scer\GAL4^Act5C.PI

(Pagliarini and Xu, 2003)

Enhancer of

Statement

Reference

scrib[+]/scrib¹ is an enhancer of abnormal planar polarity phenotype of Vang^stbm-153

(Courbard et al., 2009)

scrib¹ is an enhancer of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

scrib¹, scrib¹, Scer\GAL4^Act5C.PI is an enhancer of abnormal cell growth | larval stage | somatic clone phenotype of Raf^UAS.F179, Scer\GAL4^Act5C.PI

(Uhlirova et al., 2005)

NOT Enhancer of

Statement

Reference

scrib¹ is a non-enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

scrib¹, Scer\GAL4^Act5C.PI, puc^UAS.cMa is a suppressor of lethal | pupal stage phenotype of Ras85D^V12.UAS

(Uhlirova and Bohmann, 2006)

scrib¹ is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

scrib[+]/scrib¹ is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

scrib¹ is a non-suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

scrib¹/hep^Act.UAS, Scer\GAL4^Act5C.PI is a non-suppressor of neoplasia | somatic clone | pharate adult stage phenotype of Raf^UAS.F179, Scer\GAL4^Act5C.PI

(Uhlirova et al., 2005)

Other

Statement

Reference

Scer\GAL4^Act.PU, Xbp1^GD4745, scrib¹ has decreased cell number | somatic clone | larval stage phenotype

(Zheng et al., 2023)

Scer\GAL4^Act.PU, Xbp1^UAS.s.Tag:V5, scrib¹ has decreased cell number | somatic clone | larval stage phenotype

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has increased cell death | somatic clone | larval stage phenotype

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has decreased cell number | somatic clone | larval stage phenotype

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has decreased cell number | somatic clone | larval stage phenotype

(Zheng et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Cong et al., 2021)

JhI-21^HMS02271, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has visible | adult stage phenotype

(Cong et al., 2021)

Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, scrib¹ has increased size | larval stage | somatic clone - tissue specific phenotype

(Kong et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has neoplasia | larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has majority die during larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, ZnT86D^KK101698, scrib¹ has majority die during larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Scer\GAL4^Act5C.PI, rl^{D334N.UAS.cKa}, scrib¹ has abnormal size | somatic clone | larval stage phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{D334N.UAS.cKa}, scrib¹ has neoplasia | somatic clone | adult stage phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{R80S.D334N.UAS}, scrib¹ has abnormal size | somatic clone | larval stage phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{R80S.D334N.UAS}, scrib¹ has neoplasia | somatic clone | adult stage phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^R80S.UAS, scrib¹ has abnormal size | somatic clone | larval stage phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^R80S.UAS, scrib¹ has neoplasia | somatic clone | adult stage phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^WT.UAS, scrib¹ has abnormal size | somatic clone | larval stage phenotype

(Kushnir et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

cno^R2, scrib¹ has increased cell number | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Dll-md23, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Dll-md23, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹ has neoplasia phenotype

(Andersen et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype

(Figueroa-Clarevega and Bilder, 2015, Igaki et al., 2006)

scrib[+]/scrib¹, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has visible | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has abnormal size | somatic clone phenotype

(Külshammer et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay³, scrib¹ has lethal - all die during P-stage | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal mitotic cell cycle | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has neoplasia | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has lethal - all die during third instar larval stage phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has abnormal developmental rate phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has abnormal mitotic cell cycle | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone | cell autonomous phenotype

(Wu et al., 2010)

Stat92E⁰⁶³⁴⁶, scrib¹ has visible | somatic clone phenotype

(Wu et al., 2010)

egr¹, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Igaki et al., 2009)

egr¹, scrib¹ has hyperplasia | somatic clone | pupal stage phenotype

(Igaki et al., 2009)

Rab5^S43N.UAS, Scer\GAL4^Act5C.PI, scrib¹ has hyperplasia | somatic clone | pupal stage phenotype

(Igaki et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype

(Srivastava et al., 2007)

Ras85D^V12.UAS, scrib¹ has neoplasia | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS, scrib¹ has lethal | somatic clone | pharate adult stage phenotype

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | third instar larval stage phenotype

(Uhlirova and Bohmann, 2006)

Raf^UAS.F179, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Uhlirova et al., 2005)

Raf^UAS.F179, Scer\GAL4^Act5C.PI, hep^Act.UAS, scrib¹ has neoplasia | somatic clone | cell non-autonomous | adult stage phenotype

(Uhlirova et al., 2005)

Raf^UAS.F179, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | larval stage phenotype

(Uhlirova et al., 2005)

Eb1^42S11, scrib¹/scrib⁵ has partially lethal phenotype

(Brumby et al., 2004)

phyl^28S2/phyl[+], scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

scb^E93/scb[+], scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

Df(2L)2.3-59S16/+, scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

phyl^28S2, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

S(CycE^JP)2.4^57S6, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

S(CycE^JP)2.4^59S3, scrib¹/scrib⁵ has partially lethal phenotype

(Brumby et al., 2004)

S(CycE^JP)2.9^E1S4, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

S(CycE^JP)2.9^25S11, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

l(2)36Fd¹, scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

l(2)gl^27S3, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

l(2)gl⁴, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

l(2)gl^E2S31, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

scb^E93, scrib¹/scrib⁵ has lethal | dominant phenotype

(Brumby et al., 2004)

l(2)36Fd¹/l(2)36Fd[+], scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

S(CycE[JP])2.4[+]/S(CycE^JP)2.4^57S6, scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

S(CycE[JP])2.9[+]/S(CycE^JP)2.9^25S11, scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

S(CycE^JP)2.9^E1S4/S(CycE[JP])2.9[+], scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

l(2)gl[+]/l(2)gl^27S3, scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

l(2)gl[+]/l(2)gl⁴, scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

l(2)gl[+]/l(2)gl^E2S31, scrib¹/scrib⁵ has lethal phenotype

(Brumby et al., 2004)

N^ICN.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

N^ICN.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia phenotype

(Brumby and Richardson, 2003)

hid^GMR.PG, scrib¹ has lethal phenotype

(Brumby and Richardson, 2003)

Scer\GAL4^αTub84B.PL, bsk^K53R.UAS, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

N^ICN.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

l(3)cl-R3¹, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

BacA\p35^UAS.cHa, CycE^UAS.cRa, Scer\GAL4^αTub84B.PL, scrib¹ has hyperplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

BacA\p35^UAS.cHa, Dp^UAS.cDa, Scer\GAL4^αTub84B.PL, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

BacA\p35^UAS.cHa, Dp^UAS.cDa, Scer\GAL4^αTub84B.PL, scrib¹ has hyperplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone phenotype

(Brumby and Richardson, 2003)

hid^GMR.PG, scrib¹ has hyperplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Ire1^f02170/Ire1^f02170

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Ire1^UAS.Tag:V5/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Xbp1^GD4745

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/PEK^UAS.cMa

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Ire1^GD3071

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Ire1^HMC05163

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Ire1^HMS03003

(Zheng et al., 2023)

scrib¹ has autophagosome | larval stage | increased number | somatic clone phenotype, enhanceable by Ire1^UAS.Tag:V5/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has autophagosome | larval stage | increased number | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^D231S.UAS

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^GD6484

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^UAS.cEa

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/Hsc70-3^{UAS.ORF.Tag:HA}

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act.PU/SERCA^KK107371

(Zheng et al., 2023)

scrib¹ has eye disc | somatic clone - tissue specific phenotype, enhanceable by Scer\GAL4^Act5C.PI/msn^UAS.cSa

(Kong et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | larval stage | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval brain | larval stage | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has gonad | larval stage | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has embryonic/larval fat body | larval stage | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has embryonic/larval Malpighian tubule | larval stage | somatic clone - tissue specific phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye disc | larval stage phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has autophagosome | larval stage phenotype, enhanceable by ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

scrib¹ has wing disc phenotype, enhanceable by Def^SK3

(Parvy et al., 2019)

scrib¹ has type II neuroblast | third instar larval stage | somatic clone phenotype, enhanceable by cno^R2/cno^R2

(Rives-Quinto et al., 2017)

scrib¹ has antennal disc | third instar larval stage | somatic clone phenotype, enhanceable by cno^R2/cno^R2

(Rives-Quinto et al., 2017)

scrib¹ has antennal disc | third instar larval stage | somatic clone phenotype, enhanceable by Ras85D^V12.UAS/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

scrib¹ has eye | somatic clone phenotype, enhanceable by DCAF12^Δ1

(Hwangbo et al., 2016)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Ras85D^V12.UAS/Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

scrib¹ has eye-antennal disc | somatic clone phenotype, enhanceable by Scer\GAL4^Act5C.PI/kay^RNAi.UAS

(Uhlirova and Bohmann, 2006)

scrib¹ has eye | somatic clone phenotype, enhanceable by Scer\GAL4^Act5C.PI/bsk^K53R.UAS

(Uhlirova et al., 2005)

NOT Enhanced by

Statement

Reference

scrib¹ has eye-antennal disc | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act.PU/Atf6^VSH330216

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act.PU/crc^KK111018

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-enhanceable by crc^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act.PU/PEK^GD5584

(Zheng et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^Act.PU, Xbp1^GD4745, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Scer\GAL4^Act.PU, Xbp1^UAS.s.Tag:V5, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Scer\GAL4^Act.PU, Xbp1^UAS.s.Tag:V5, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by bsk^DN.UAS/Scer\GAL4^Act.PU

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^Act.PU

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Diap1^UAS.cHa

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/Dronc^DN.UAS.cUa

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by Scer\GAL4^Act.PU/BacA\p35^UAS.cHa

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by Scer\GAL4^Act.PU/Diap1^UAS.cHa

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by Scer\GAL4^Act.PU/Dronc^DN.UAS.cUa

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has autophagosome | increased number | somatic clone | larval stage phenotype, suppressible | partially by bsk^DN.UAS/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has eye | somatic clone phenotype, suppressible | partially by Ire1^f02170/Ire1^f02170

(Zheng et al., 2023)

scrib¹ has eye | somatic clone phenotype, suppressible | partially by Ire1^UAS.Tag:V5/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has eye | somatic clone phenotype, suppressible | partially by Scer\GAL4^Act.PU/Xbp1^GD4745

(Zheng et al., 2023)

scrib¹ has eye | somatic clone phenotype, suppressible | partially by Scer\GAL4^Act.PU/Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^Act.PU/BacA\p35^UAS.cHa

(Zheng et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by JhI-21^HMS02271, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by JhI-21^KK112996, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, scrib¹ has eye disc | somatic clone - tissue specific phenotype, suppressible | partially by Scer\GAL4^Act5C.PI/msn^UAS.cSa

(Kong et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has gonad | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has gonad | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval brain | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval brain | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye disc | larval stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has autophagosome | larval stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye disc | larval stage phenotype, suppressible | partially by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has autophagosome | larval stage phenotype, suppressible | partially by bsk^DN.UAS/ZnT86D^KK101698, Scer\GAL4^Act.PU

(Wei et al., 2021)

scrib¹ has wing disc phenotype, suppressible by Def^SK3

(Parvy et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | third instar larval stage phenotype, suppressible by Ets21C^KK103211/kay^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by Ets21C^KK103211/kay^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by egr¹/egr³

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | third instar larval stage phenotype, suppressible by kay³/kay³

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by kay³/kay³

(Katheder et al., 2017)

Scer\GAL4^FRT.Act5C, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | partially | somatic clone by fmt^UAS.cMa/Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

cno^R2, scrib¹ has larval brain | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Mmmm\ras^N17.UAS

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has larval brain | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Ras85D^KK108029/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has larval brain | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has larval brain | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Scer\GAL4^Dll-md23/Akt^KK100495

(Rives-Quinto et al., 2017)

scrib¹ has larval brain | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

scrib¹ has eye | somatic clone phenotype, suppressible by DCAF12^UAS.cHa

(Hwangbo et al., 2016)

scrib¹ has wing disc | third instar larval stage phenotype, suppressible by hep^r75

(Bunker et al., 2015)

scrib¹ has wing disc | third instar larval stage phenotype, suppressible by yki^B5

(Bunker et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

scrib¹ has embryonic/larval hemocyte | larval stage phenotype, suppressible by egr³/egr³

(Parisi et al., 2014)

scrib¹ has wing disc phenotype, suppressible by egr³/egr³

(Parisi et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has ommatidium | somatic clone phenotype, suppressible by cher¹

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has photoreceptor neuron | somatic clone phenotype, suppressible by cher¹

(Külshammer and Uhlirova, 2013)

scrib¹ has wing disc phenotype, suppressible by hep^r75

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone phenotype, suppressible by dome^ΔCYT.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone phenotype, suppressible by Stat92E⁰⁶³⁴⁶, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by egr¹

(Igaki et al., 2009)

scrib¹ has wing disc | somatic clone | third instar larval stage phenotype, suppressible by egr¹

(Igaki et al., 2009)

scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by egr^UAS.cIa/Scer\GAL4^Act5C.PI

(Igaki et al., 2009)

scrib¹ has eye | somatic clone phenotype, suppressible by egr^UAS.cIa/Scer\GAL4^Act5C.PI

(Igaki et al., 2009)

scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by Scer\GAL4^Act5C.PI/Rab5^S43N.UAS

(Igaki et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by Mmp1^Q273/Mmp1^Q273

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by Timp^UAS.cSa/Reck^UAS.cSa, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has basement membrane | somatic clone phenotype, suppressible by Timp^UAS.cSa/Reck^UAS.cSa, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006, Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by Timp^UAS.cPa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by Timp^UAS.cPa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible | partially by Mmp1^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible | partially by Mmp1^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible | partially by Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible | partially by Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by Mmp1^RNAi.UAS/Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by Mmp1^RNAi.UAS/Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

scrib¹ has epithelial cell phenotype, suppressible by Hsap\SCRIB^UAS.EGFP/Scer\GAL4^αTub84B.PL

(Dow et al., 2003)

scrib¹ has eye disc | somatic clone phenotype, suppressible by Hsap\SCRIB^UAS.EGFP/Scer\GAL4^αTub84B.PL

(Dow et al., 2003)

scrib¹ has photoreceptor neuron | somatic clone phenotype, suppressible by Hsap\SCRIB^UAS.EGFP/Scer\GAL4^αTub84B.PL

(Dow et al., 2003)

NOT suppressed by

Statement

Reference

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has autophagosome | increased number | somatic clone | larval stage phenotype, non-suppressible by Xbp1^GD4745, Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by Scer\GAL4^Act.PU/Atf6^VSH330216

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by Scer\GAL4^Act.PU/crc^KK111018

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by crc^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^Act.PU

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by Scer\GAL4^Act.PU/PEK^GD5584

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by Atg13^G6421/Atg13^G6421

(Zheng et al., 2023)

scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by Atg6⁰⁰⁰⁹⁶/Atg6⁰⁰⁰⁹⁶

(Zheng et al., 2023)

cno^R2, scrib¹ has larval brain | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by cno^UAS.cBa/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has larval brain | somatic clone | third instar larval stage phenotype, non-suppressible | somatic clone by Raf^KK100982/Scer\GAL4^Dll-md23

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, non-suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Enhancer of

Statement

Reference

scrib¹/scrib¹ is an enhancer | somatic clone of type II neuroblast | third instar larval stage | somatic clone phenotype of cno^R2

(Rives-Quinto et al., 2017)

scrib[+]/scrib¹ is an enhancer of ommatidium phenotype of Vang^stbm-153

(Courbard et al., 2009)

scrib¹ is an enhancer of eye-antennal disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

NOT Enhancer of

Statement

Reference

scrib¹ is a non-enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

scrib¹ is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

scrib[+]/scrib¹ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

scrib¹ is a non-suppressor of adult Malpighian tubule | somatic clone phenotype of Ras85D^ΔC40B

(Zeng et al., 2010)

scrib¹ is a non-suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Other

Statement

Reference

Scer\GAL4^Act.PU, Xbp1^GD4745, scrib¹ has eye-antennal disc | somatic clone phenotype

(Zheng et al., 2023)

Scer\GAL4^Act.PU, Xbp1^UAS.s.Tag:V5, scrib¹ has eye-antennal disc | somatic clone phenotype

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype

(Zheng et al., 2023)

Ire1^UAS.Tag:V5, Scer\GAL4^Act.PU, scrib¹ has autophagosome | increased number | somatic clone | larval stage phenotype

(Zheng et al., 2023)

Ire1^f02170, scrib¹ has eye-antennal disc | somatic clone phenotype

(Zheng et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone | larval stage phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype

(Cong et al., 2021)

JhI-21^HMS02271, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype

(Cong et al., 2021, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, scrib¹ has eye disc | somatic clone - tissue specific phenotype

(Kong et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye disc | larval stage phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has autophagosome | larval stage phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has larval brain | larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has gonad | larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has embryonic/larval fat body | larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Raf^UAS.F179, Scer\GAL4^Act.PU, scrib¹ has embryonic/larval Malpighian tubule | larval stage | somatic clone - tissue specific phenotype

(Wei et al., 2021)

Scer\GAL4^Act5C.PI, rl^{D334N.UAS.cKa}, scrib¹ has eye disc | somatic clone phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{D334N.UAS.cKa}, scrib¹ has adult abdomen phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{D334N.UAS.cKa}, scrib¹ has antennal disc phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{R80S.D334N.UAS}, scrib¹ has eye disc | somatic clone phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{R80S.D334N.UAS}, scrib¹ has adult abdomen phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^{R80S.D334N.UAS}, scrib¹ has antennal disc phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^R80S.UAS, scrib¹ has eye disc | somatic clone phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^R80S.UAS, scrib¹ has adult abdomen phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^R80S.UAS, scrib¹ has antennal disc phenotype

(Kushnir et al., 2020)

Scer\GAL4^Act5C.PI, rl^WT.UAS, scrib¹ has eye disc | somatic clone phenotype

(Kushnir et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

cno^R2, scrib¹ has larval brain | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has type II neuroblast | increased number | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

cno^R2, scrib¹ has intermediate neuronal progenitor | increased number | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Dll-md23, scrib¹ has type II neuroblast | increased number | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

scrib[+]/scrib¹, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has ommatidium | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has eye | somatic clone phenotype

(Külshammer et al., 2015)

egr¹/egr³, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Khoo et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has ommatidium | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has photoreceptor neuron | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has eye-antennal disc | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has eye phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has ommatidium phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone | cell autonomous phenotype

(Wu et al., 2010)

Stat92E⁰⁶³⁴⁶, scrib¹ has eye | somatic clone phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has basement membrane | somatic clone phenotype

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype

(Uhlirova and Bohmann, 2006)

Raf^UAS.F179, Scer\GAL4^Act5C.PI, hep^Act.UAS, scrib¹ has adult head | somatic clone phenotype

(Uhlirova et al., 2005)

Raf^UAS.F179, Scer\GAL4^Act5C.PI, hep^Act.UAS, scrib¹ has retina | somatic clone phenotype

(Uhlirova et al., 2005)

Hsap\SCRIB^UAS.EGFP, Scer\GAL4^Act.PU, scrib¹/scrib^j7B3 has wing phenotype

(Dow et al., 2003)

Hsap\SCRIB^UAS.EGFP, Scer\GAL4^Act.PU, scrib¹/scrib^j7B3 has eye phenotype

(Dow et al., 2003)

Hsap\SCRIB^UAS.EGFP, Scer\GAL4^Act.PU, scrib¹/scrib^j7B3 has scutellar bristle | ectopic phenotype

(Dow et al., 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has basal lamina & eye disc | somatic clone phenotype

(Pagliarini and Xu, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Clones both expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and homozygous for scrib¹ form tumors in the larval brain (which metastasize to the ventral nerve cord). Larval eye/antennal disc clones also form tumors and their induction leads to lethality. Co-expression of JhI-21^HMS02271 suppresses tumorigenesis and lethality, but adults exhibit an eye phenotype.

Eye/antennal disc clones both expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and homozygous for dlg1¹⁴ also form tumors.

(Cong et al., 2021)

Eye-disc specific clones (using ey-FLP) homozygous for scrib¹ and expressing Raf^UAS.F179 under the control of Scer\GAL4^Act.PU develop invasive tumors in larval gonads, eye-antennal discs and brain; there is metastization to the ventral nerve cord, fat body and Malpighian tubules.

(Wei et al., 2021)

scrib¹ homozygous eye disc clones that also express either rl^WT.UAS, rl^R80S.UAS, rl^{D334N.UAS.cKa} or rl^{D334N.UAS.cKa} (under the control of Scer\GAL4^Act5C.PI) are larger than clones only homozygous for scrib¹; scrib¹ homozygous antennal disc clones are readily visible on the rl^R80S.UAS-, rl^{D334N.UAS.cKa} and rl^{D334N.UAS.cKa}- expressing conditions, but hardly detected in the rl^WT.UAS-expressing condition. In agreement, individuals bearing such double mutant clones show abdominal accumulation the rl^R80S.UAS-, rl^{D334N.UAS.cKa} and rl^{D334N.UAS.cKa}- expressing conditions, but not in the rl^WT.UAS-expressing condition.

(Kushnir et al., 2020)

Third instar larval eye-antennal imaginal disc clones homozygous for scrib¹ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU form invasive tumors; the presence of these clones in egr¹/egr³ transheterozygotes, or additional clonal homozygosity for kay³, or additional clonal co-expression of Ets21C^KK103211 in combination with kay^{dsRNA.Scer\UAS.cUa} do not lead to significant cell non-autonomous induction of autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc cells.

(Katheder et al., 2017)

The small size of scrib¹ mutant MARCM clones that are recovered in third instar larval eye-antennal discs is significantly rescued if the clones also express fmt^Scer\UAS.cMa under the control of Scer\GAL4^{Scer\FRT.Act5C}.

(Ma et al., 2017)

The small size of Type II neuroblast lineage MARCM clones mutant for scrib¹ in third instar larvae can be rescued by expression of bsk^DN.Scer\UAS under the control of Scer\GAL4^Dll-md23 in the mutant clones, these clones are also recovered more frequently than scrib¹-only mutant clones. scrib¹ clones expressing Ras85D^V12.Scer\UAS can be recovered at a similar rate as wild-type ones and instead of a single neuroblast they frequently contain 2 or 3 but the clones do not show significant overgrowth.

scrib¹ mutant clones in larval antennal discs occasionally display overgrowth, clones double mutant for both scrib¹ and cno^R2 frequently show clear tumorigenic overgrowth, while scrib¹ clones expressing Ras85D^V12.Scer\UAS (under the control of Scer\GAL4^Dll-md23) are all tumor-like.

Type II neuroblast lineage MARCM clones double mutant for cno^R2 and scrib¹ display a strong tumor-like overgrowth with clone areas significantly larger than either of the single mutant clones or the control wild-type clones in third instar larvae. The cno^R2;scrib¹ clones are composed of almost exclusively of progenitor cells (dpn-positive) with few differentiated cells and in respect to overgrowth capacity fall into two categories - about half of the clones does not overgrow while the other half does, about a third of which massively so. The double mutant clones contain significantly more neuroblast and intermediate neural progenitor (INP) cells compared to wild-type clones but the relative proportion of mature INPs is reduced (although their absolute number per clone is also increased). The asymmetric localization major asymmetric cell division regulators in metaphase/anaphase NBs fails in all the mutant clones. The overgrowth and increased number of progenitor cells characteristic for cno^R2;scrib¹ clones is significantly suppressed by Scer\GAL4^Dll-md23-driven expression of Ras85D^KK108029, cno^Scer\UAS.cBa or Akt1^KK100495, but not cno^ΔN.Scer\UAS or Raf^KK100982 in the mutant clones.

(Rives-Quinto et al., 2017)

scrib¹/scrib¹;DCAF12^Δ1/DCAF12^Δ1 double mutant clones show increased tissue overgrowth and scrib¹/scrib¹ mutant clones overexpressing DCAF12^Scer\UAS.cHa show enhanced tissue integrity (compared to scrib¹/scrib¹ clones).

(Hwangbo et al., 2016)

scrib¹ eye discs expressing Ras85D^V12.Scer\UAS in clones show a dramatic tumour-like overgrowth and metastasis.

(Andersen et al., 2015)

The tumor phenotype of scrib¹ homozygous third instar larval wing discs is suppressed by hep^r75 hemizygosity or yki^B5 heterozygosity.

(Bunker et al., 2015)

Transplanted scrib¹ mutant eye disc fragments expressing MARCM closes of Ras85D^V12.Scer\UAS grow continuously and induce distinctive bloating of the abdomen before killing the host. Wild-type discs grow only a limited amount before ceasing, and the transplanted host survives for weeks. Metastasis-like events are rare for the tumors. However, all the tumor-bearing hosts show robust wasting phenotypes in tissues distant from the transplant. Transplanted wild-type disc fragments do not induce these phenotypes. Cachexia-like wasting is observed in adipose tissue (fat body), muscle, and ovaries. Comparison of food consumption in wild-type and tumor-bearing hosts show that he tumor-induced wasting is not due to decreased food consumption (anorexia).

(Figueroa-Clarevega and Bilder, 2015)

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in wts^x1/+;scrib¹/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

(Keder et al., 2015)

The majority of larvae with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU exhibit defective photoreceptor differentiation, and developmental arrest as third instar giant larvae and die; only a few individuals form pseudopuparia and are developmentally delayed, starting on day 8 after egg laying. The cells of scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU are highly invasive, penetrating the ventral nerve cord of a majority of developmentally arrested larvae.

Clonal co-expression of Ets21C^KK103211 partially suppresses the lethality and developmental delay seen in larvae with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, but fails to suppress the invasive infiltration of the ventral nerve cord exhibited by cells of these clones.

Clonal co-expression of ftz-f1^JF02738 or kay^{N-Ala.Scer\UAS}, or addition of a clonal kay³ mutation, but not co-expression of Jra^{dsRNA.Scer\UAS}, partially suppresses the lethality and developmental delay seen in larvae with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and suppresses the invasive infiltration of the ventral nerve cord exhibited by cells of these clones, although the tumor mass is not significantly decreased.

Larvae with scrib¹ mutant eye-antennal disc clones expressing ftz-f1^JF02738, Ets21C^KK103211, and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU reach pupation faster than larvae with scrib¹ mutant eye-antennal disc clones expressing ftz-f1^JF02738 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, or those with scrib¹ mutant eye-antennal disc clones expressing Ets21C^KK103211 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Clonal co-expression of kay^{N-Ala.Scer\UAS}, or addition of a clonal kay³ mutation, but not co-expression of Jra^{dsRNA.Scer\UAS} or ftz-f1^JF02738, partially suppresses the defective photoreceptor differentiation seen in scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Larvae with scrib¹, kay³ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS and Ets21C^KK103211 under the control of Scer\GAL4^Act.PU exhibit suppression of larval lethality as compared to either larvae with scrib¹, kay³ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, or those with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS and Ets21C^KK103211 under the control of Scer\GAL4^Act.PU; but these larvae still exhibit pupal lethality.

Adults with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS and ftz-f1^JF02738 under the control of Scer\GAL4^Act.PU exhibit a rough eye that is increased in size, and contains fewer clonally-derived ommatidia, as compared to controls.

(Külshammer et al., 2015)

The increased density of circulating hemocytes observed in in scrib¹ larvae is suppressed by egr³ homozygosity.

(Parisi et al., 2014)

Somatic clones (induced specifically in the eye disc) expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU and homozygous mutant for scrib¹ show substantial tumorigenic overgrowth but do not form secondary tumors although floating clone cells are frequently observed in the hemolymph.

(Hirabayashi et al., 2013)

The egr¹/egr³ background fully suppresses the increased cell death seen in eye-antennal disc scrib¹/scrib¹ mutant clones, and also leads to overgrowth of these clones.

(Khoo et al., 2013)

Ras85D^V12.Scer\UAS scrib¹ tumour cells fail to differentiate into neurons.

Loss of cher markedly interferes with the growth of Ras85D^V12.Scer\UAS scrib¹ tumours. The loss of cher does not affect the level of apoptosis in either the clonal nor the surrounding eye-antennal imaginal disc, indicating that loss of cher does not affect tumour cell viability.

Eye-antennal imaginal discs carrying Ras85D^V12.Scer\UAS scrib¹ cher¹ clones display extra cell divisions, mainly occurring in the surrounding non-clonal tissue. Despite sizeable Ras85D^V12.Scer\UAS scrib¹ cher¹ clones clones located posterior to the morphogenetic furrow, the number of elav-positive differentiating photoreceptors increases and their organization is better than in Ras85D^V12.Scer\UAS scrib¹ clones. Consequently, well-ordered arrays of ommatidia appear in Ras85D^V12.Scer\UAS scrib¹ cher¹ eye-antennal imaginal discs compared with the indiscernible pattern in Ras85D^V12.Scer\UAS scrib¹ discs.

Many apically localised Ras85D^V12.Scer\UAS scrib¹ cells are elongated.

Cross-sections of Ras85D^V12.Scer\UAS scrib¹ cher¹ eye-antennal discs reveals that large tumours only reside within the basal compartment of the columnar epithelium. Smaller Ras85D^V12.Scer\UAS scrib¹ cher¹ clones are confined between the squamous peripodial epithelium and the columnar epithelium.

In contrast to highly invasive Ras85D^V12.Scer\UAS scrib¹ clonal tumours, fewer Ras85D^V12.Scer\UAS scrib¹ cher¹ clones invaded the brain and the ventral nerve cord. Expression of cher^KK107518 suppresses the tumour invasiveness found in Ras85D^V12.Scer\UAS scrib¹ clones.

Larvae bearing Ras85D^V12.Scer\UAS scrib¹ tumours all die in the third instar and never pupate. In contrast, on day 8-9 after egg laying, 30% of Ras85D^V12.Scer\UAS scrib¹ cher¹ larvae begin to wander and pupate, albeit 2-3 days later than control animals. Thirty percent of Ras85D^V12.Scer\UAS scrib¹ cher¹ pupape emerge as adults. These adult flies exhibit abnormally enlarged eyes with a folded surface, accommodating surplus ommatidia.

Expression of zip^GD1566 lessens the invasiveness of Ras85D^V12.Scer\UAS scrib¹ tumours and improves pupation rate.

(Külshammer and Uhlirova, 2013)

Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones exhibit tissue overgrowth. Exposure to acivicin restrains Ras85D^V12.Scer\UAS-scrib¹ tumor overgrowth.

Knockdown of CTPsyn, through expression of CTPsyn^GD4740, induces a strong, significant reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of CG9674, through expression of CG9674^GD14285, induces a strong, significant reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of bur, through expression of bur^GD13797, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of r, through expression of r^GD9607, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of ade2, through expression of ade2^GD1356, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of Gfat1, through expression of Gfat1^GD7732, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of Prat, through expression of Prat^GD9838, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of Prat2, through expression of Prat2^GD16167, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of CG9940, through expression of CG9940^GD14730, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

(Willoughby et al., 2013)

Expression of either bsk^{dsRNA.Scer\UAS}, bsk^DN.Scer\UAS, Traf6^{dsRNA.Scer\UAS} or Ced-12^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act.PU in the cells surrounding scrib¹ clones in the eye-antennal disc significantly suppresses the elimination of the mutant scrib¹ clones compared to that seen when the cells surrounding the clone are wild type.

Expression of either Pvr^Scer\UAS.cDa or egr^Scer\UAS.cIa under the control of Scer\GAL4^Act.PU in the cells surrounding scrib¹ clones in the eye-antennal disc significantly enhances the elimination of the mutant scrib¹ clones compared to that seen when the cells surrounding the clone are wild type.

Expression of egr^IR.Scer\UAS under the control of Scer\GAL4^Act.PU only within scrib¹ clones in the eye-antennal disc results in 30.7% pupal lethality, while expression of egr^IR.Scer\UAS under the control of Scer\GAL4^Act.PU both within scrib¹ clones in the eye-imaginal disc and in the surrounding wild-type cells results in 51.3% pupal lethality.

In an egr¹ mutant background, scrib¹ mutant clones in the eye-antennal disc are no longer eliminated, but grow aggressively and develop into tumours. In this background, expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^Act.PU only in the cells surrounding the scrib¹ clones reverses the tumour phenotype; the scrib¹ clones do not overgrow and are out-competed by the surrounding cells.

Expression of Pvr^{dsRNA.Scer\UAS.cRa} under the control of Scer\GAL4^Act.PU in the cells surrounding scrib¹ clones in the eye-antennal disc significantly suppresses the elimination of the mutant scrib¹ clones compared to that seen when the cells surrounding the clone are wild type.

(Ohsawa et al., 2011)

scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU grow into large metastatic tumors. Wild type cells are almost completely absent from late Ras85D^V12.Scer\UAS scrib¹ tumors.

Eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, develop into large tumors capable of invading the ventral nerve cord. In the late stages of tumor development most cells in the tumor mass are Ras85D^V12.Scer\UAS cells and scrib¹ cells and wild type cells are almost completely absent.

Stat92E⁰⁶³⁴⁶ partially suppresses the overgrowth and invasion of the nerve cord seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of dome^{ΔCYT.Scer\UAS} suppresses the overgrowth and invasion of the nerve cord seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of dome^{ΔCYT.Scer\UAS} in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, suppresses the overgrowth and invasion of the nerve cord.

No tumors are seen when upd1^Scer\UAS.cUa is expressed under the control of Scer\GAL4^Act.PU in scrib¹ mutant eye-antennal clones.

No tumors are seen when upd1^Scer\UAS.cUa is expressed under the control of Scer\GAL4^Act.PU in wild type eye-antennal disc cells that are adjacent to scrib¹ mutant cells.

The eye is reduced in size when scrib¹ mutant clones are generated in eye-antennal discs in which adjacent cells are mutant for Stat92E⁰⁶³⁴⁶.

Expression of bsk^DN.Scer\UAS in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, partially suppresses the tumor phenotype. Few scrib¹ cells remain in the tissue at late stages.

Expression of bsk^DN.Scer\UAS suppresses the tumors seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Stat92E⁰⁶³⁴⁶ in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, partially suppresses the overgrowth and completely abrogates the invasion of the nerve cord.

Hemizygous hep^r75 suppresses the wing disc tumors seen in scrib¹ mutant larvae.

(Wu et al., 2010)

Ras85D^ΔC40B, scrib¹ double mutant adult Malpighian tubule clones display only a few differentiated renalcytes (RCs), like the single Ras85D^ΔC40B mutant phenotype.

(Zeng et al., 2010)

Heterozygosity for scrib¹ enhances the frequency of ommatidia that show planar cell polarity defects in Vang^stbm-153 homozygotes.

(Courbard et al., 2009)

scrib¹ mutant clones survive in egr¹ mutant eye-antennal discs background. Overgrowth of double mutant cells is observed, and tumor development is observed in pupal eye-antennal tissue. scrib¹ mutant clones generated in egr¹ mutant wing discs also survive, and tumor development is observed in the wing disc.

Tumour formation and animal lethality are both completely rescued by over-expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^Act5C.PI in scrib¹, egr¹ double mutant clones.

Expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^Act5C.PI in scrib¹ somatic mutant clones results in a reduction in the size of the clones by 86.5%, and mutant clones are not evident in adult eyes.

Expression of Rab5^{S43N.Scer\UAS} under the control of Scer\GAL4^Act5C.PI in scrib¹ somatic mutant clones results in aggressive overgrowth of eye-antennal disc mutant tissue.

(Igaki et al., 2009)

Clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹ show invasive behaviour, invading the ventral nerve cord. These clones show degradation of the basement membrane.

Co-expression of bsk^DN.Scer\UAS suppresses the invasive behaviour of clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹.

The invasive behaviour of clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹ is partially suppressed in a Mmp1^Q273 homozygous background.

The invasive behaviour and degradation of the basement membrane of clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹ is suppressed if the clones are also co-expressing both Reck^Scer\UAS.cSa and Timp^Scer\UAS.cSa simultaneously.

(Srivastava et al., 2007)

Expression of Ras85D^V12.Scer\UAS in scrib¹ mutant clones results in massive and metastatic tumours. After 6 days the cells exhibit moderate tumour growth and ventral nerve cord invasion phenotypes. Co-expression of bsk^DN.Scer\UAS and Ras85D^V12.Scer\UAS in scrib¹ mutant clones completely blocks the invasion of the ventral nerve cord as well as secondary tumour foci formation.

The presence of an Akt1¹ mutant background considerably reduces the tumour load in scrib¹ mutant clones expressing Ras85D^V12.Scer\UAS (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system but does not impair metastatic behaviour.

Overexpression of Akt1^{Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system in brain somatic clones mutant for scrib¹ and wts^x1 does not cause metastatic behaviour despite accelerated tumour growth.

(Igaki et al., 2006)

Clones of eye/antennal imaginal disc cells that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI and are also homozygous for scrib¹ show an enhancement of the tumorigenic phenotype seen in clones that are mutant for either scrib¹ or express Ras85D^V12.Scer\UAS. The Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ cells become invasive; at 6 days after egg laying, imaginal disc cells appear in the ventral nerve cord (VNC). At day 9, the invading cells obscure the eye/antennal discs, brain lobes, and the VNC so these anatomical structures are no longer distinguishable. The invading tumor cells are morphologically distinct and have a prominent actin cytoskeleton network typical of cells undergoing movement or shape change.

Animals bearing Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clones progress normally through larval development but fail to pupate and die as third instar larvae and around day 13 AEL.

Expression of bsk^DN.Scer\UAS clones blocks the cell invasive phenotype of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ eye/antennal imaginal disc clones. These clones still overgrow in the discs but never leave this structure. bsk^DN.Scer\UAS expression also rescues the larval lethality of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clone-bearing animals, with rescued animals progressing through most of metamorphosis and dying as pharate adults.

Expression of puc^Scer\UAS.cMa in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ eye/antennal imaginal disc clones prevents the invasion cell phenotype but does not rescue the overgrowth of the eye/antennal imaginal disc clones. puc^Scer\UAS.cMa expression rescues the larval lethality of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clone-bearing animals and partially restores pupariation.

scrib¹ eye/antennal imaginal disc clones grow larger in size when they express kay^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act5C.PI. Apoptosis is suppressed in the Scer\GAL4^Act5C.PI>kay^{dsRNA.Scer\UAS}; scrib¹ clones.

Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, Timp^Scer\UAS.cPa, scrib¹ eye/antennal disc clones produce a tumor mass larger than that seen in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ disc clones. However, the tumor cell invasiveness observed in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clones is suppressed by expression of Timp^Scer\UAS.cPa.

Expression of either Mmp1^{dsRNA.Scer\UAS} or Mmp2^{dsRNA.Scer\UAS} in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ eye/antennal imaginal disc clones significantly suppresses the cell invasiveness phenotype but does not suppress the formation of tumors within the disc. Coexpression of Mmp1^{dsRNA.Scer\UAS} and Mmp2^{dsRNA.Scer\UAS} further reduces the invasiveness of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ cells.

(Uhlirova and Bohmann, 2006)

Downregulation of JNK signaling in clones of scrib¹ mutant tissue by overexpression of bsk^{K53R.Scer\UAS} suppresses apoptosis (from 16.6% to wild-type levels of 25%) and increases the overgrowth of the tissue, even compared to wild-type, resulting in scrib¹ bsk^{K53R.Scer\UAS} clones contributing over 70% of the tissue in third instar eye imaginal discs.

Clones of eye imaginal discs that express phl^{Scer\UAS.F179} autonomously (under the control of Scer\GAL4^Act5C.PI) in scrib¹ clones grow into massive and invasive tumours during larval stages, resulting in 80% of animals not pupating and dying as giant larvae.

Expression of hep^Act.Scer\UAS in eye imaginal disc clones that express phl^{Scer\UAS.F179} (under the control of Scer\GAL4^Act5C.PI) and scrib¹ results in adult eyes with massive overgrowth. The heads are significantly bigger and the retina of these mutants are dramatically larger than that of a wild-type eye. In many cases, the retina is folded and bunched to accommodate the surfeit of tissue. These severely hyperplastic eye structures are well patterned and show a distinctive ommatidial organisation. The tumourous overgrowth is induced non-autonomously in the wild-type cells surrounding the hep^Act.Scer\UAS phl^{Scer\UAS.F179} (both under the control of Scer\GAL4^Act5C.PI) scrib¹ cells.

(Uhlirova et al., 2005)

dlg1¹⁴ ; scrib¹/+ neuroblasts show defects in division; 52% undergo normal division, 32% undergo a symmetrical division and 16% undergo an inverted asymmetrical division. dlg1¹⁴ ; l(2)gl^unspecified/+ ; scrib¹/+ neuroblasts show defects in division; 56% undergo normal division, 22% undergo a symmetrical division and 22% undergo an inverted asymmetrical division.

(Albertson and Doe, 2003)

When bsk^{K53R.Scer\UAS} is driven by Scer\GAL4^αTub84B.PL in scrib¹ clones in the eye, a significant increase in the size of scrib¹ clones is seen. However, this combination leads to pupal lethality. When scrib¹ clones are made in eyes expressing hid^GMR.PG the viability of the mutant clones increases dramatically. This results in tissue overgrowth and lethality. When scrib¹ clones are made in regions of eye disc tissue that are l(3)cl-R3¹ (made by FLP clones in the eye), the scrib¹ clone is not eliminated by apoptosis as seen in wild-type tissue but overproliferates, losing recognisable structure, resulting in lethality. When Ras85D^V12.Scer\UAS or N^ICN.Scer\UAS are expressed in scrib¹ clones, massive overproliferation of the scrib¹ tissue is seen inducing larval/pupal lethality. Co-expression of CycE^Scer\UAS.cRa with BacA\p35^Scer\UAS.cHa in scrib¹ clones results in some overgrowth and pupal lethality. Co-expression of Dp^Scer\UAS.cDa with BacA\p35^Scer\UAS.cHa in scrib¹ clones results in some overgrowth and pupal lethality. The addition of E2f1⁹¹ or dap^{Scer\UAS.cdNa} suppresses the overproliferation phenotype seen in scrib¹, Ras85D^V12.Scer\UAS, Scer\GAL4^αTub84B.PL clones.

(Brumby and Richardson, 2003)

Marked clones in the eye disc expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI and which are also homozygous for scrib¹ show metastatic behaviour. The basement membrane has many points of discontinuity in eye discs containing clones which are homozygous for scrib¹ and which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI, and mutant cells spread from these areas. The metastatic behaviour seen in clones in the eye disc which are homozygous for scrib¹ and are also expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI is suppressed if they are co-expressing shg^Scer\UAS.cOa but is not suppressed if they are co-expressing argos::shg^{i.Scer\UAS.T:Hsap\MYC}. The metastatic behaviour seen in clones in the eye disc which are homozygous for scrib¹ and are also expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI is not suppressed if they are co-expressing Hsap\CDKN1A^Scer\UAS.cHa; although the tumour size is decreased, mutant cells can still spread into the ventral nerve cord. Marked clones in the eye disc which are homozygous for scrib¹ and are expressing BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PI do not show metastatic behaviour. Marked clones in the eye disc which are homozygous for scrib¹ and are co-expressing Dp^Scer\UAS.cDa, E2f^Scer\UAS.cNa and BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PI do not show metastatic behaviour. Expression of either dm^Scer\UAS.cZa or Akt1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act5C.PI in clones in the eye disc which are homozygous for scrib¹ increases the amount of mutant tissue compared to scrib¹ single mutant clones, but the double mutant clones do not show metastatic behaviour. scrib¹ wts^x1 double mutant clones in the eye disc produce tumours which do not show metastatic behaviour. Expression of Akt1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act5C.PI in scrib¹ wts^x1 double mutant clones in the eye disc increases tumour size but does not result in metastatic behaviour.

(Pagliarini and Xu, 2003)

Xenogenetic Interactions

Statement

Reference

When BacA\p35^Scer\UAS.cHa is driven by Scer\GAL4^αTub84B.PL in scrib¹ clones in the eye, the amount of mutant tissue surviving to adulthood increases compared with scrib¹ clones alone.

Co-expression of CycE^Scer\UAS.cRa with BacA\p35^Scer\UAS.cHa in scrib¹ clones results in some overgrowth and pupal lethality.

(Brumby and Richardson, 2003)

Expression of Hsap\Scrib^{Scer\UAS.T:Avic\GFP-EGFP} (under the control of Scer\GAL4^αTub84B.PL) within MARCM-generated scrib¹ clones largely restores the differentiation and patterning of the photoreceptors in the eye. Hsap\Scrib^{Scer\UAS.T:Avic\GFP-EGFP} expression also suppresses the tissue organisation defects associated with scrib¹ mutant tissue.

scrib¹ mutant clones expressing Hsap\Scrib^{Scer\UAS.T:Avic\GFP-EGFP} (under the control of Scer\GAL4^αTub84B.PL) restores the columnar architecture and monolayer organization of the epithelial cells, while the cytoskeleton appears normal.

Ubiquitous expression of Hsap\Scrib^{Scer\UAS.T:Avic\GFP-EGFP} (under the control of Scer\GAL4^Act.PU) effectively suppresses the larval overgrowth phenotype found in scrib¹/scrib^j7B3 mutants. Expression of Hsap\Scrib^{Scer\UAS.T:Avic\GFP-EGFP} in scrib¹/scrib^j7B3 mutant third instar imaginal wings suppresses the tumorous overgrowth of the epithelial tissues and allows the formation of a monolayered epithelial structure closely resembling that of wild-type discs.

Expression of Hsap\Scrib^{Scer\UAS.T:Avic\GFP-EGFP} (under the control of Scer\GAL4^Act.PU) rescues larval lethality in scrib¹/scrib^j7B3 mutants to allow 59% to form adult structures (pharate adults) and 23% to eclose as mature adult flies. These adult flies exhibit some developmental defects in the eyes and wings on a proportion of rescued animals as well as ectopic scutellar bristles, suggesting the rescue effect is not fully penetrant. Both sexes appear to be sterile.

(Dow et al., 2003)

Complementation and Rescue Data

Fails to complement

scrib⁸⁸²

(Zeitler et al., 2004)

scrib^ird15

(Zeitler et al., 2004)

scrib⁶⁷³

(Zeitler et al., 2004)

scrib^dt12

(Zeitler et al., 2004)

scrib^dt14

(Zeitler et al., 2004)

scrib^dt6

(Zeitler et al., 2004)

scrib^smi97B

(Ganguly et al., 2003)

Rescued by

scrib¹ is rescued by Scer\GAL4^wor.PA/scrib^UAS.Tag:MYC

(Albertson et al., 2004)

scrib¹ is rescued by Scer\GAL4^wor.PA/scrib^{ΔCT.UAS.Tag:MYC}

(Albertson et al., 2004)

scrib¹ is rescued by scrib^UAS.cBa/Scer\GAL4^BG487

(Roche et al., 2002)

scrib¹ is rescued by Scer\GAL4^futsch-C380/scrib^UAS.cBa

(Roche et al., 2002)

Not rescued by

scrib¹ is not rescued by scrib^{LRR.UAS.Tag:MYC}/Scer\GAL4^wor.PA

(Albertson et al., 2004)

scrib¹ is not rescued by Scer\GAL4^wor.PA/scrib^{ΔPDZ.UAS.Tag:MYC}

(Albertson et al., 2004)

scrib¹ is not rescued by Scer\GAL4^wor.PA/scrib^{PDZ.UAS.Tag:MYC}

(Albertson et al., 2004)

scrib¹ is not rescued by Scer\GAL4^wor.PA/scrib^{ΔLRR.UAS.Tag:MYC}

(Albertson et al., 2004)

scrib¹ is not rescued by Scer\GAL4^wor.PA/scrib^{CT.UAS.Tag:MYC}

(Albertson et al., 2004)

Comments

Expression of scrib^{ΔCT.Scer\UAS.T:Hsap\MYC} or scrib^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^wor.PA significantly restores normal asymmetric divisions in homozygous scrib¹ stage 15 neuroblasts.

Expression of either scrib^{CT.Scer\UAS.T:Hsap\MYC}, scrib^{LRR.Scer\UAS.T:Hsap\MYC}, scrib^{ΔPDZ.Scer\UAS.T:Hsap\MYC}, scrib^{PDZ.Scer\UAS.T:Hsap\MYC} or scrib^{ΔLRR.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^wor.PA fails to restore normal asymmetric divisions in homozygous scrib¹ stage 15 neuroblasts.

(Albertson et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

(Weber et al., 2012)

7c10

(Bilder and Perrimon, 2000)

Scrib¹

(Xiao et al., 2025, O'Keefe et al., 2015, Zeng et al., 2010)

scrb¹

(Schmidt et al., 2018, Cervantes-Sandoval et al., 2016)

scrib 1

(Zeitler et al., 2004)

scrib-1

(Gerlach et al., 2022)

scrib^-

(Srivastava et al., 2007)

scrib¹

(Chen et al., 2025, Dillard et al., 2025, Julick et al., 2025, Kong et al., 2025, Kakemura and Igaki, 2024, Mitchell et al., 2024, Wang et al., 2024, Zheng et al., 2023, Cao et al., 2022, de Vreede et al., 2022, Gerlach et al., 2022, Khoury and Bilder, 2022, Kong et al., 2022, Liu et al., 2022, Yang et al., 2022, Cong et al., 2021, Hodgson et al., 2021, Ito and Igaki, 2021, Khezri et al., 2021, Kong et al., 2021, Manzanero-Ortiz et al., 2021, Wei et al., 2021, Wei et al., 2021, Canales Coutiño et al., 2020, Khoury and Bilder, 2020, Kushnir et al., 2020, Sanaki et al., 2020, Ji et al., 2019, Mishra-Gorur et al., 2019, Murcia et al., 2019, Parvy et al., 2019, de Vreede et al., 2018, Donohoe et al., 2018, Katsukawa et al., 2018, Poernbacher and Vincent, 2018, Katheder et al., 2017, Ma et al., 2017, Rives-Quinto et al., 2017, Yamamoto et al., 2017, Atkins et al., 2016, Andersen et al., 2015, Bunker et al., 2015, Figueroa-Clarevega and Bilder, 2015, Keder et al., 2015, Külshammer et al., 2015, de Vreede et al., 2014, Parisi et al., 2014, Stickel and Su, 2014, Hirabayashi et al., 2013, Khoo et al., 2013, Külshammer and Uhlirova, 2013, Turkel et al., 2013, Willoughby et al., 2013, Grusche et al., 2011, Ohsawa et al., 2011, Rhiner et al., 2010, Wu et al., 2010, Courbard et al., 2009, Igaki et al., 2009, Rhiner et al., 2009, Lighthouse et al., 2008, Igaki et al., 2006, Igaki et al., 2006, Uhlirova and Bohmann, 2006, Uhlirova et al., 2005, Albertson et al., 2004, Dow et al., 2003)

scribble¹

(Rosen et al., 2019, Hwangbo et al., 2016)

Name Synonyms

Secondary FlyBase IDs

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