FlyBase Allele Report: Dmel\S6k[l-1]

S6k^l-1 homozygous somatic clones in third instar larval eye discs do not exhibit any delay in G1/S transition during the second mitotic wave, as mutant cells enter S phase in a similar region to control cells.

(Kim et al., 2017)

S6k^l-1 mutant intestinal stem cell clones do not show any maintenance defects.

(Quan et al., 2013)

The autophagy defects observed in S6k^l-1 mutant larval fat body cells are consistent with its suggested positive role in autophagy.

(Pircs et al., 2012)

Bouton number/muscle area at the neuromuscular junction is normal in S6k^l-1/Df(3L)CH18 third instar larvae. However, the mean bouton size is reduced approximately 40% compared to wild type. The number of active zones and the total synaptic area is significantly reduced at the mutant neuromuscular junction. Mean synaptic area is decreased more than active zone number, resulting in an increase in active zone density compared to wild type.

The mean amplitude of the spontaneous miniature excitatory postsynaptic potential (miniature EPSP) at the neuromuscular junction is normal in homozygous and S6k^l-1/Df(3L)CH18 third instar larvae, although the miniature EPSP frequency is reduced in S6k^l-1/Df(3L)CH18 third instar larvae compared to wild type. The mean amplitude of the evoked EPSP at the neuromuscular junction is significantly decreased in homozygous and S6k^l-1/Df(3L)CH18 third instar larvae compared to wild type. There is also a correlated decrease in the quantal content in the mutant animals.

(Cheng et al., 2011)

S6k^l-1/S6k⁰⁷⁰⁸⁴ mutant adult flies have a reduced body weight compared to heterozygous controls. Wing area is also reduced compared to controls.

Lipid content is increased in S6k^l-1/S6k⁰⁷⁰⁸⁴ mutant flies compared to controls. Carbohydrate content is similar to controls.

S6k^l-1/S6k⁰⁷⁰⁸⁴ mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is significantly reduced in S6k^l-1/S6k⁰⁷⁰⁸⁴ mutant flies compared to controls.

(Murillo-Maldonado et al., 2011)

S6k^l-1 adult escapers exhibit a bent-down wing phenotype.

(Montagne et al., 2010)

Homozygous dendrite arborization neuron clones show a of the dendritic arbors compared to wild type, with significant reductions in both the number and length of dendritic branches.

(Koike-Kumagai et al., 2009)

Eyes that are entirely comprised of S6k^l-1 mutant clones (generated using W^GMR.PG) are slightly smaller than in wild type.

(Xu et al., 2008)

Cells mutant for S6k^l-1 show a strong decrease in TR-avidin uptake.

(Hennig et al., 2006)

Ommatidial size in S6k^l-1/S6k^l-1 flies is reduced to 0.71 of wild-type.

(Stocker et al., 2003)

Cells in S6k^l-1 mutant clones in the eye are 0.65 times the size of their heterozygous neighbours.

(Gao et al., 2002)

Compared with wild-type pupae, S6k^l-1 homozygous larvae are significantly reduced in size.

(Radimerski et al., 2002)

Mosaic eyes consisting primarily of mutant ommatidia are slightly smaller than normal due to decreases in ommatidium size.

(Potter et al., 2001)

The wing discs of S6k^l-1 mutants are smaller than wild-type. The size of the nuclei in the endoreplicating salivary gland is smaller than wild-type.

(Oldham et al., 2000)

The few homozygous escapers that do survive, emerge after a 5 day delay and live no longer than two weeks. They have a severe reduction in body size, with all body parts apparently affected to the same extent. Bristles are proportionate to the body size. The cell density is higher than wild-type (when wings and eyes are examined), the cells are almost 30% smaller, however the total number of cells remain normal. Wing discs are significantly smaller than wild-type and their cell size is on average smaller than wild-type. There is no apparent difference in the distribution of cell between wild-type and mutant within each phase of the cell cycle in larval discs. This is also the case when examined during early prepupal stage. The number of cells in S6k^l-1 homozygous somatic clones are reduced compared to wildtype. Cell cycle times are 24+/-4 hours (compared to 12+/-1 in wild-type).

(Montagne et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

S6k^l-1 has visible | adult stage | somatic clone phenotype, enhanceable by Scer\GAL4^GMR.PF/RpL8^RNAi.UAS

(Xu et al., 2008)

S6k^l-1 has abnormal size | adult stage | somatic clone phenotype, enhanceable by Scer\GAL4^GMR.PF/RpL8^RNAi.UAS

(Xu et al., 2008)

NOT Enhanced by

Statement

Reference

S6k^l-1 has decreased body size | pupal stage phenotype, non-enhanceable by Tsc1[+]/Tsc1^Q87X

(Radimerski et al., 2002)

Suppressed by

Statement

Reference

S6k^l-1 has decreased cell size | somatic clone phenotype, suppressible by gig¹⁹²/gig¹⁹²

(Gao et al., 2002)

S6k[+]/S6k^l-1, Tsc1^Q87X has lethal phenotype, suppressible | partially by mTor^2L1/Tor[+]

(Radimerski et al., 2002)

NOT suppressed by

Statement

Reference

Df(3L)CH18/S6k^l-1 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Pdk1^UAS.Tag:FLAG

(Cheng et al., 2011)

S6k^l-1 has decreased body size | pupal stage phenotype, non-suppressible by Tsc1[+]/Tsc1^Q87X

(Radimerski et al., 2002)

S6k^l-1 has visible | recessive | somatic clone phenotype, non-suppressible by Tsc1^Q600X

(Potter et al., 2001)

Enhancer of

Statement

Reference

S6k[+]/S6k^l-1 is an enhancer of visible phenotype of Scer\GAL4^ey.PH, Tctp^RNAi.UAS

(Hsu et al., 2007)

NOT Enhancer of

Statement

Reference

S6k^l-1, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Radimerski et al., 2002)

Suppressor of

Statement

Reference

S6k[+]/S6k^l-1 is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

S6k[+]/S6k^l-1 is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Hsap\LRRK2^UAS.cVa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

S6k^l-1 is a suppressor of decreased cell death | somatic clone phenotype of gig⁵⁶

(Quan et al., 2013)

S6k[+]/S6k^l-1 is a suppressor | partially of abnormal neurophysiology | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

S6k[+]/S6k^l-1 is a suppressor of abnormal neurophysiology | larval stage phenotype of Scer\GAL4^G14, mTor^{WT.UAS.Tag:FLAG}

(Penney et al., 2012)

S6k^l-1 is a suppressor of increased cell death | somatic clone phenotype of Rbf^120a, gig¹⁹²

(Hsieh et al., 2010)

S6k^l-1 is a suppressor of increased cell death | somatic clone phenotype of Rbf^120a

(Hsieh et al., 2010)

S6k^l-1 is a suppressor of increased cell death phenotype of Rbf^15aΔ, gig⁶⁴

(Li et al., 2010)

S6k^l-1 is a suppressor of increased cell death phenotype of Rbf^15aΔ, gig¹⁹²

(Li et al., 2010)

S6k[+]/S6k^l-1 is a suppressor of partially lethal - majority die phenotype of Atg1^EP3348

(Lee et al., 2007)

S6k^l-1/S6k^l-1 is a suppressor of increased cell size | somatic clone phenotype of gig¹⁹²

(Gao et al., 2002)

S6k[+]/S6k^l-1 is a suppressor | partially of lethal phenotype of Tsc1^Q87X, mTor^2L1/Tor[+]

(Radimerski et al., 2002)

S6k^l-1/S6k^l-1 is a suppressor of increased cell size | somatic clone phenotype of Tsc1^Q87X

(Radimerski et al., 2002)

S6k[+]/S6k^l-1 is a suppressor of lethal | larval stage phenotype of Tsc1^Q87X

(Radimerski et al., 2002)

S6k^l-1/S6k^l-1 is a suppressor of lethal | larval stage phenotype of Tsc1^Q87X

(Radimerski et al., 2002)

S6k[+]/S6k^l-1 is a suppressor of visible phenotype of Pdk1^A467V.UAS, Scer\GAL4^ap-md544

(Rintelen et al., 2001)

NOT Suppressor of

Statement

Reference

S6k^l-1/S6k^l-1 is a non-suppressor of increased cell size | somatic clone phenotype of Pten¹¹⁷

(Radimerski et al., 2002)

S6k^l-1 is a non-suppressor of visible phenotype of Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Radimerski et al., 2002)

Other

Statement

Reference

Keap1^EY02632, S6k⁰⁷⁰⁸⁴/S6k^l-1 has chemical resistant | adult stage phenotype

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Keap1^EY02632, S6k⁰⁷⁰⁸⁴/S6k^l-1 has abnormal oxidative stress response | adult stage phenotype

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Keap1^EY02632, S6k⁰⁷⁰⁸⁴/S6k^l-1 has increased rate of adult locomotory behavior phenotype

(Álvarez-Rendón and Riesgo-Escovar, 2023)

S6k[+]/S6k^l-1, mTor^ΔP has abnormal neuroanatomy | dominant phenotype

(Koike-Kumagai et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

S6k^l-1 has eye | somatic clone phenotype, enhanceable by Scer\GAL4^GMR.PF/RpL8^RNAi.UAS

(Xu et al., 2008)

Suppressed by

Statement

Reference

S6k^l-1 has wing phenotype, suppressible by Scer\GAL4^ap-md544/Hr3^ΔDBD.UAS

(Montagne et al., 2010)

NOT suppressed by

Statement

Reference

Df(3L)CH18/S6k^l-1 has NMJ bouton | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Pdk1^UAS.Tag:FLAG

(Cheng et al., 2011)

S6k^l-1 has ommatidium | somatic clone phenotype, non-suppressible by Tsc1^Q600X

(Potter et al., 2001)

Enhancer of

Statement

Reference

S6k[+]/S6k^l-1 is an enhancer of eye phenotype of Scer\GAL4^ey.PH, Tctp^RNAi.UAS

(Hsu et al., 2007)

NOT Enhancer of

Statement

Reference

S6k^l-1 is a non-enhancer of eye phenotype of Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Radimerski et al., 2002)

S6k^l-1 is a non-enhancer of ommatidium phenotype of Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Radimerski et al., 2002)

Suppressor of

Statement

Reference

S6k[+]/S6k^l-1 is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

S6k[+]/S6k^l-1 is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Hsap\LRRK2^UAS.cVa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

S6k^l-1 is a suppressor of intestinal stem cell | somatic clone phenotype of gig⁵⁶

(Quan et al., 2013)

S6k^l-1 is a suppressor of enteroendocrine cell | somatic clone phenotype of gig⁵⁶

(Quan et al., 2013)

S6k[+]/S6k^l-1 is a suppressor | partially of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

S6k[+]/S6k^l-1 is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of Scer\GAL4^G14, mTor^{WT.UAS.Tag:FLAG}

(Penney et al., 2012)

S6k^l-1 is a suppressor of eye disc | somatic clone phenotype of Rbf^120a, gig¹⁹²

(Hsieh et al., 2010)

S6k^l-1 is a suppressor of eye disc morphogenetic furrow | somatic clone phenotype of Rbf^120a

(Hsieh et al., 2010)

S6k^l-1 is a suppressor of eye disc anterior to the morphogenetic furrow | somatic clone phenotype of Rbf^120a

(Hsieh et al., 2010)

S6k^l-1 is a suppressor of eye | somatic clone phenotype of Rbf^15aΔ, gig⁶⁴

(Li et al., 2010)

S6k^l-1 is a suppressor of eye | somatic clone phenotype of Rbf^15aΔ, gig¹⁹²

(Li et al., 2010)

S6k⁰⁷⁰⁸⁴/S6k^l-1 is a suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Khurana et al., 2006)

S6k^l-1/S6k^l-1 is a suppressor | partially of eye phenotype of Rheb^UAS.cSa, Scer\GAL4^GMR.PF

(Saucedo et al., 2003)

S6k^l-1/S6k^l-1 is a suppressor of ommatidium phenotype of Rheb^EP50.084, Scer\GAL4^GMR.PF

(Stocker et al., 2003)

S6k[+]/S6k^l-1 is a suppressor | partially of ommatidium phenotype of Rheb^EP50.084, Scer\GAL4^GMR.PF, mTor^2L1/Tor[+]

(Stocker et al., 2003)

S6k^l-1/S6k^l-1 is a suppressor of eye | somatic clone phenotype of Tsc1^Q87X

(Radimerski et al., 2002)

S6k^l-1/S6k^l-1 is a suppressor of ommatidium | somatic clone phenotype of Tsc1^Q87X

(Radimerski et al., 2002)

S6k[+]/S6k^l-1 is a suppressor of wing phenotype of Pdk1^A467V.UAS, Scer\GAL4^ap-md544

(Rintelen et al., 2001)

NOT Suppressor of

Statement

Reference

S6k[+]/S6k^l-1 is a non-suppressor of autophagosome | conditional phenotype of Atg1^EP3348

(Lee et al., 2007)

S6k^l-1/S6k^l-1 is a non-suppressor of eye | somatic clone phenotype of Pten¹¹⁷

(Radimerski et al., 2002)

S6k^l-1/S6k^l-1 is a non-suppressor of ommatidium | somatic clone phenotype of Pten¹¹⁷

(Radimerski et al., 2002)

S6k^l-1 is a non-suppressor of eye phenotype of Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Radimerski et al., 2002)

S6k^l-1 is a non-suppressor of ommatidium phenotype of Pi3K92E^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Radimerski et al., 2002)

Other

Statement

Reference

S6k[+]/S6k^l-1, mTor^ΔP has dendrite phenotype

(Koike-Kumagai et al., 2009)

S6k[+]/S6k^l-1, mTor^ΔP has larval dorsal multidendritic neuron ddaC phenotype

(Koike-Kumagai et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

S6k^l-1 homozygous somatic clones also expressing Thor^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL in third instar larval eye discs do not exhibit any delay in G1/S transition during the second mitotic wave, as mutant cells enter S phase in a similar region to control cells.

(Kim et al., 2017)

S6k^l-1/+ suppresses the increase in excitatory junction current amplitude and quantal content seen in larvae NMJs expressing Lrrk^Scer\UAS.cIa under the control of Scer\GAL4^Mhc.PW.

(Penney et al., 2016)

S6k^l-1 gig⁵⁶ double mutant intestinal stem cell clones display a similar maintenance rate to that of wild-type intestinal stem cell clones, indicating that disruption of S6k can fully suppress the gig⁵⁶-induced intestinal stem cell loss phenotype.

S6k^l-1 gig⁵⁶ double mutant intestinal stem cells do not exhibit obvious defects in lineage differentiation, as enteroendocrine cells and enterocyte cells are correctly differentiated in the clones.

(Quan et al., 2013)

Expression of Pdk1^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^VGlut-OK371 does not rescue the reduction in bouton size which is seen at the neuromuscular junction in S6k^l-1/Df(3L)CH18 third instar larvae.

(Cheng et al., 2011)

The basal level of E2f-dependent cell death normally present in Rbf^120a mutant eye discs is suppressed in S6k^l-1 mutant cells.

The ectopic cell death observed in Rbf^120a gig¹⁹² is completely absent in Rbf^120a gig¹⁹² S6k^l-1 triple mutant cells.

(Hsieh et al., 2010)

The presence of a S6k^l-1 background significantly decreases gig⁶⁴/Rbf^15aΔ induced cell death in the eye. In addition, much larger gig⁶⁴/Rbf^15aΔ double mutant clones are observed in adult eyes.

The presence of a S6k^l-1 background significantly decreases gig¹⁹²/Rbf^15aΔ induced cell death in the eye. In addition, much larger gig¹⁹²/Rbf^15aΔ double mutant clones are observed in adult eyes.

(Li et al., 2010)

Expression of Hr46^{ΔDBD.Scer\UAS} under the control of Scer\GAL4^ap-md544 suppresses the bent-down wing phenotype found in a S6k^l-1 background.

(Montagne et al., 2010)

The dendritic branches of ddaC neurons in Tor^ΔP/+ ; S6k^l-1/+ double heterozygous larvae have fewer branch points than wild-type controls.

(Koike-Kumagai et al., 2009)

Expression of RpL8^{dsRNA.Scer\UAS} under the control of Scer\GAL4^GMR.PF enhances the reduction in eye size seen in S6k^l-1 mutant clones.

(Xu et al., 2008)

The reduction in eye size seen in animals expressing Tctp^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ey.PH is enhanced if they are also carrying S6k^l-1/+.

(Hsu et al., 2007)

Defects in autophagosome formation in starved Atg1^EP3348 homozygous larvae are not rescued in a S6k^l-1 heterozygous background. However, eclosion rates are increased in these animals in a dose-dependent manner and approximately 70% of Atg1^EP3348, S6k^l-1/+ animals eclose.

(Lee et al., 2007)

No difference in body weight between S6k⁰⁷⁰⁸⁴/S6k^l-1 scyl³¹/scyl³¹ double mutants and S6k⁰⁷⁰⁸⁴/S6k^l-1 single mutants is seen.

(Reiling and Hafen, 2004)

Eye overgrowth in Rheb^Scer\UAS.cSa; Scer\GAL4^GMR.PF animals is not suppressed by S6k^l-1/S6k^l-1, but ommatidia are smaller and less disorganized than those of Rheb^Scer\UAS.cSa; Scer\GAL4^GMR.PF alone, and the resulting eyes have a distinctive puckered appearance.

(Saucedo et al., 2003)

The large size and disorganisation of ommatidia in Scer\GAL4^GMR.PF/+; Rheb^EP50.084/+ flies is suppressed by S6k^l-1/S6k^l-1. The partial dominant suppression of the large size and disorganisation of ommatidia in Scer\GAL4^GMR.PF/+; Rheb^EP50.084/+ flies by Tor^2L1 (ommatidia are 1.27 times wild-type size, and slightly disorganised) is enhanced by S6k^l-1/+ (ommatidia 1.16 times wild-type size, and not disorganised).

(Stocker et al., 2003)

The increase in cell size seen in somatic clones of gig¹⁹² in the eye is completely suppressed in double mutant somatic clones with S6k^l-1. The decrease in cell size seen in somatic clones of S6k^l-1 in the eye is completely suppressed in double mutant somatic clones with gig¹⁹².

(Gao et al., 2002)

The size reduction seen in S6k^l-1 homozygous larvae is not significantly affected by heterozygosity for Tsc1^Q87X. The second instar lethality of homozygous Tsc1^Q87X is rescued to early pupal stages in a S6k^l-1 homozygous background, however, the larvae are small and severely delayed in development. In contrast, in a S6k^l-1/+ background Tsc1^Q87X homozygous animals develop to early pupal stages with little developmental delay, and are significantly larger than wild type. The second instar lethality of homozygous Tsc1^Q87X is rescued to adulthood (62%) or pupal stages (93%) by heterozygosity for both S6k^l-1 and Tor^2L1. The rescued animals are slightly larger than wild-type flies, with overall patterning appearing normal. The rescued females are semi-fertile when crossed to wild-type males, whereas the rescued males are fully fertile when crossed to wild-type females. Eye overgrowth caused by somatic clones of Tsc1^Q87X in the developing eye and the increase in ommatidia size within the clones are suppressed in homozygous S6k^l-1 animals. Eye overgrowth caused by somatic clones of Pten¹¹⁷ in the developing eye and the increase in ommatidia size within the clones are not suppressed in homozygous S6k^l-1 animals.

(Radimerski et al., 2002)

The enlarged eye and ommatidia phenotype caused by expression of Pi3K92E^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF is not affected if the flies are also homozygous for S6k^l-1.

(Radimerski et al., 2002)

Mosaic eyes consisting primarily of double mutant S6k^l-1 Tsc1^Q600X ommatidia show the S6k^l-1 single mutant phenotype.

(Potter et al., 2001)

Xenogenetic Interactions

Statement

Reference

S6k^l-1/+ fully suppresses the increase in excitatory junction current amplitude and quantal content seen in larvae NMJs expressing Hsap\LRRK2^Scer\UAS.cVa under the control of Scer\GAL4^Mhc.PW.

(Penney et al., 2016)

Expression of Hsap\RPL8^DN.Scer\UAS under the control of Scer\GAL4^GMR.PF enhances the reduction in eye size seen in S6k^l-1 mutant clones.

(Xu et al., 2008)

The rough-eye phenotype observed in animals expressing Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed in a S6k⁰⁷⁰⁸⁴/S6k^l-1 background.

(Khurana et al., 2006)

Complementation and Rescue Data

Fails to complement

S6k⁰⁷⁰⁸⁴

(Montagne et al., 1999)

Rescued by

Df(3L)CH18/S6k^l-1 is rescued by Scer\GAL4^elav-C155/S6k^STDETE.UAS

(Cheng et al., 2011)

Df(3L)CH18/S6k^l-1 is rescued by Scer\GAL4^elav-C155/S6k^UAS.cCa

(Cheng et al., 2011)

Df(3L)CH18/S6k^l-1 is rescued by Scer\GAL4^VGlut1-OK371/S6k^UAS.cCa

(Cheng et al., 2011)

S6k^l-1 is rescued by S6k^UAS.cWa/Scer\GAL4^Act5C.PP

(Kockel et al., 2010)

Not rescued by

Df(3L)CH18/S6k^l-1 is not rescued by Scer\GAL4^elav-C155/S6k^KQ.UAS

(Cheng et al., 2011)

Df(3L)CH18/S6k^l-1 is not rescued by S6k^UAS.cCa/Scer\GAL4^C57

(Cheng et al., 2011)

Comments

The decrease in bouton size which is seen at the neuromuscular junction in S6k^l-1/Df(3L)CH18 third instar larvae is fully rescued by expression of S6k^Scer\UAS.cCa under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^VGlut-OK371, but is not rescued by expression of S6k^Scer\UAS.cCa under the control of Scer\GAL4^C57.

Expression of S6k^Scer\UAS.cCa under the control of Scer\GAL4^elav-C155 rescues the reduced active zone number and reduced reduced total synaptic area seen at the neuromuscular junction of S6k^l-1/Df(3L)CH18 third instar larvae.

The decrease in bouton size which is seen at the neuromuscular junction in S6k^l-1/Df(3L)CH18 third instar larvae is not rescued by expression of S6k^KQ.Scer\UAS under the control of Scer\GAL4^elav-C155.

The decrease in bouton size which is seen at the neuromuscular junction in S6k^l-1/Df(3L)CH18 third instar larvae is rescued by expression of S6k^{STDETE.Scer\UAS} under the control of Scer\GAL4^elav-C155 and the boutons are actually increased in size compared to wild type in the rescued animals.

The reduced active zone number and reduced reduced total synaptic area seen at the neuromuscular junction of S6k^l-1/Df(3L)CH18 third instar larvae is also rescued by expression of S6k^{STDETE.Scer\UAS} under the control of Scer\GAL4^elav-C155 (the numbers are actually increased in size compared to wild type in the rescued animals).

(Cheng et al., 2011)

Expression of S6k^Scer\UAS.cWa under the control of Scer\GAL4^Act5C.PP rescues the lethality associated with S6k^l-1.

(Kockel et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32552

y¹ w^*; S6k^l-1/TM6B, P{Car20y}TPN1, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

DrosophilaS6K^l-1

(Xu et al., 2008)

S6K¹¹

(Scott et al., 2004)

S6K^I-1

(Wei et al., 2019)

S6K^l-1

(Kim et al., 2017, Pircs et al., 2012, Cheng et al., 2011, Koike-Kumagai et al., 2009, Xu et al., 2008, Reiling and Hafen, 2004)

S6K^l1

(Hennig et al., 2006, Scott et al., 2004)

S6k^I-1

(Deichsel et al., 2024)

S6k^L-1

(Bateman and McNeill, 2004)

S6k^l-1

(Deichsel et al., 2024, Álvarez-Rendón and Riesgo-Escovar, 2023, Álvarez-Rendón and Riesgo-Escovar, 2020, Luo et al., 2020, Penney et al., 2016, Quan et al., 2013, Penney et al., 2012, Tokusumi et al., 2012, Kockel et al., 2010, Li et al., 2010, Khurana et al., 2006)

S6k^l1

(Montagne et al., 2010)

dS6K^I-1

(Murillo-Maldonado et al., 2011)

dS6K^l-1

(Lee et al., 2007)

dS6K^l1

(Radimerski et al., 2002, Radimerski et al., 2002)

dS6k^l-1

(Hsu et al., 2007, Rintelen et al., 2001)

ds6k^I-1

(Parker and Struhl, 2015)

p70s6K^l-1

s6k^l-1

(Hsieh et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (38)

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