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General Information
Symbol
Dmel\eyJ5.71
Species
D. melanogaster
Name
FlyBase ID
FBal0104630
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation is due to a 9kb deletion in the 5' region of the ey gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous eyJ5.71 mutant escaper adults are not headless.

20% of mutant flies show a 50-75% reduction in the size of the eye, and 80% of mutant flies show a 75-100% reduction in the size of the eye.

Homozygotes show 81% lethality. Eyes are reduced in size in homozygotes; 80% have eyes that are 0-25% of wild-type size and 20% have eyes that are 25-50% of wild-type size. eyJD/eyJ5.71 flies show 72% lethality. Eyes are reduced in size in eyJD/eyJ5.71 flies; 22% have eyes that are 0-25% of wild-type size, 72% have eyes that are 25-50% of wild-type size, 6% have eyes that are 50-75% of wild-type size and 0% have eyes that are 75-100% of wild-type size. eyJD/eyJ5.71 flies show severe mushroom body and central complex defects. Eyes are reduced in size in eyD1Da/eyJ5.71 flies; 43% have eyes that are 0-25% of wild-type size, 14% have eyes that are 25-50% of wild-type size, 38% have eyes that are 50-75% of wild-type size and 5% have eyes that are 75-100% of wild-type size. eyD1Da/eyJ5.71 flies show severe mushroom body and central complex defects.

No defects are seen in the embryonic central nervous system.

Expression of eyScer\UAS.ΔHD when driven by Scer\GAL4dpp.blk1 in a eyJ5.71 background leads to ectopic eyes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

eyJ5.71 has eye phenotype, suppressible by toyUAS.cCa/Scer\GAL4ey.PH

NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of toyScer\UAS.cCa under the control of Scer\GAL4toy1 significantly suppresses the lethality seen in eyJ5.71 mutants, raising the fraction of homozygous adults from 12% to 26.8% at 18[o]C. The compound eyes of eyJ5.71 homozygotes are fully restored by one copy of toyScer\UAS.cCa.

The ectopic eyes seen in flies in which Scer\GAL4dpp.blk1 drives expression from toyScer\UAS.cCa, toyΔHD.Scer\UAS or Mmus\Pax6Scer\UAS.cHa are not suppressed by eyJ5.71/eyJ5.71.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

eyJ5.71 is partially rescued by ey+t.p6

Not rescued by
Comments

Embryonic and pupal lethality developmental delay, eye phenotypes and male sterility due to eyJ5.71/eyJ5.71 are all rescued by ey+t.p6. However, female sterility is not. When somatic clones lacking ey+t.p6 are induced in the late second or early third instar, eyes carrying these clones appear normal.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (14)