FB2025_01 , released February 20, 2025
Allele: Dmel\Sose49
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General Information
Symbol
Dmel\Sose49
Species
D. melanogaster
Name
FlyBase ID
FBal0105103
Feature type
allele
Associated gene
Dmel\Sos
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In Sose49/+ embryos, midline crossovers are seen in the pCC/MP2 pathway axons in 39% of embryos. An average of 2.1 crossovers are seen per embryo.

        (Fritz and VanBerkum, 2002)

        The longitudinal connectives are often spaced closer together in homozygotes than in wild-type embryos and 39% of embryos show Fas2-positive axons crossing the midline.

        (Fritz and VanBerkum, 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        NOT Enhanced by
        Statement
        Reference

        Sose49 has dMP2 neuron phenotype, non-enhanceable by Cdc42N17.UAS/Scer\GAL4ftz.ng

        (Fritz and VanBerkum, 2002)

        Sose49 has pCC neuron phenotype, non-enhanceable by Cdc42N17.UAS/Scer\GAL4ftz.ng

        (Fritz and VanBerkum, 2002)

        Sose49 has vMP2 neuron phenotype, non-enhanceable by Cdc42N17.UAS/Scer\GAL4ftz.ng

        (Fritz and VanBerkum, 2002)
        Suppressed by
        NOT suppressed by
        Statement
        Reference

        Sose49 has dMP2 neuron phenotype, non-suppressible by Cdc42N17.UAS/Scer\GAL4ftz.ng

        (Fritz and VanBerkum, 2002)

        Sose49 has pCC neuron phenotype, non-suppressible by Cdc42N17.UAS/Scer\GAL4ftz.ng

        (Fritz and VanBerkum, 2002)

        Sose49 has vMP2 neuron phenotype, non-suppressible by Cdc42N17.UAS/Scer\GAL4ftz.ng

        (Fritz and VanBerkum, 2002)
        Enhancer of
        Statement
        Reference

        Sose49 is an enhancer of larval longitudinal connective phenotype of sli2

        (Fritz and VanBerkum, 2000)
        NOT Enhancer of
        Statement
        Reference

        Sos[+]/Sose49 is a non-enhancer of phenotype of robo11

        (Fritz and VanBerkum, 2000)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of Rho1N19.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49 homozygous embryos enhances the midline crossover phenotype seen in the pCC/MP2 pathway axons. 94% of embryos exhibit the phenotype. An average of 7.0 crossovers are seen per embryo. The addition of Rho1V14.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49 homozygous embryos suppresses the midline crossover phenotype seen in the pCC/MP2 pathway axons. 1.6% of embryos exhibit the phenotype. An average of 1.0 crossovers are seen per embryo. The addition of Rac1N17.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49 homozygous embryos enhances the midline crossover phenotype seen in the pCC/MP2 pathway axons. 91% of embryos exhibit the phenotype. An average of 8.0 crossovers are seen per embryo. The addition of Rac1V12.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49 homozygous embryos enhances the midline crossover phenotype seen in the pCC/MP2 pathway axons. % of embryos exhibit the phenotype. An average of crossovers are seen per embryo. The addition of Cdc42N17.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49/+ embryos has no effect on the midline crossover phenotype seen in the pCC/MP2 pathway axons. The addition of Cdc42V12.Scer\UAS (driven by Scer\GAL4ftz.ng) to Sose49 homozygous embryos enhances the midline crossover phenotype seen in the pCC/MP2 pathway axons. All embryos exhibit the phenotype.

        (Fritz and VanBerkum, 2002)

        Approximately 24% of heterozygous sli2 embryos show periodic crossovers of Fas2-positive axons across the midline. The penetrance of this phenotype is enhanced by one copy of Sose49.

        (Fritz and VanBerkum, 2000)
        Xenogenetic Interactions
        Statement
        Reference

        In double homozygous Sose49 Khc::Ggal\MLCKKA.ftz embryos the pCC/MP2 pathway freely crosses the midline in almost every segment.

        (Fritz and VanBerkum, 2000)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Sose49
        Name Synonyms
        Secondary FlyBase IDs
          References (2)