FB2021_02, released April 13, 2021

Allele: Dmel\ato2

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General Information
Symbol
Dmel\ato2
Species
D. melanogaster
Name
FlyBase ID
FBal0117591
Feature type
allele
Associated gene
Dmel\ato
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(White and Jarman, 2000)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Transposition insertion (of X chromosomal material) between 7 and 8kb upstream of the ato open reading frame, separating the eye-specific 5' enhancer element from the ato open reading frame.

      (White and Jarman, 2000)
      Caused by aberration
      Tp(1;3)ato2
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ato1/ato2 antenna have a small number of coeloconic sensilla. The antennal lobes have normal glomeruli and the inter-antennal commissure is present. The elaboration of glial cell processes within the antennal lobe is normal.

      (Jhaveri and Rodrigues, 2002)

      ato1/ato2 flies have severely reduced eyes, which nevertheless contain ommatidia (approximately 200-300 in males, 5-15 in females). The ommatidia mostly contain fewer photoreceptors than wild type. The photoreceptor clusters are variably reduced, containing from 1-8 photoreceptors and any or all of the recruited photoreceptors can be affected. Photoreceptor axons navigate to the optic stalk poorly. This axon pathfinding defect is more severe in females. Those axons that reach the optic stalk are able to continue to their target sites within the optic lobe.

      (White and Jarman, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      ato2 has phenotype, suppressible by ed4.12

      (Rawlins et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ato2
      Name Synonyms
      Secondary FlyBase IDs
        References (4)