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General Information
Symbol
Dmel\lilliXS575
Species
D. melanogaster
Name
FlyBase ID
FBal0121691
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

4,926bp deletion, removing exons 4-8 including the translational start site.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cuticle from late homozygous embryos is normal. Embryos derived from homozygous female germline clones show pair-rule segmentation defects. Two classes of phenotype are seen; 52% of embryos are missing odd numbered segments, with the remaining denticle belts often fused (44%), while the other class of embryos fail to secrete cuticle properly. These two phenotypes are similarly observed whether wild-type or heterozygous males are used to produce the embryos. The germband never extends beyond 25% of dorsal egg length in embryos derived from homozygous female germline clones (in contrast to wild-type, where germband extension reaches 60% of dorsal egg length). The formation of the cephalic furrow is also delayed. Embryos derived from homozygous female germline clones show specific defects in the maintenance of the actin network during cellularisation. The initial phase of cellularisation occurs normally. However, during the second phase of cellularisation, specific defects in the maintenance of the contractile actin network are seen, as the actin network begins to contract and the furrow tips move basally. The actin filaments become unevenly distributed between nuclei, ranging from abnormally large bundles to regions where the actin network is thin or absent, resulting in multinucleate cells. The microtubular baskets surrounding each nucleus appear largely normal, even in regions where actin filaments are unevenly distributed. At the end of cellularisation, the yolk stalks are irregular in shape and size, and large connections between cortical cells and the central yolk cell are often seen. The timing of cellularisation and membrane formation is unimpaired however, and does result in an epithelial monolayer of cells with proper apical-basal polarity in these embryos. Defects in the transport of organelles are also seen during cellularisation; the cortical clearing (as the cortical cytoplasm becomes depleted of lipid droplets) is perturbed, resulting in a "halo" of non-cleared cytoplasm around the central yolk. Yolk vesicle movement is normal during cellularisation and the general distribution of microtubule arrays is largely unaffected. Homozygous clones induced in the third larval instar eye and wing imaginal discs at either 24-36 hours or 36-48 hours after egg deposition are indistinguishable from their wild-type twinspots in terms of their size and number of cells 96 hours after induction. Homozygous clones result in smaller photoreceptor cells and wing margin bristles than normal, although other cell types in the adult eye and wing are unaffected. The size of mutant cells in clones in the developing wing and eye imaginal discs appear normal. Mutant cells in the wing disc show a normal cell cycle profile.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

lilliXS575 is a suppressor of visible phenotype of sinaGMR.PN

lilliXS575 is a suppressor of visible phenotype of ttk88.GMR.Tag:MYC

lilliXS575 is a suppressor of visible phenotype of aopACT.GMR

lilliXS575 is a suppressor of visible phenotype of phylGMR.PC

Phenotype Manifest In
Enhancer of
Statement
Reference

lilliXS575 is an enhancer of phenotype of Ras85DV12.sev

lilliXS575 is an enhancer of phenotype of EgfrE1

NOT Enhancer of
Statement
Reference

lilliXS575 is a non-enhancer of phenotype of aopACT.sev

lilliXS575 is a non-enhancer of phenotype of Nact.sev

lilliXS575 is a non-enhancer of phenotype of rlSem.sev

lilliXS575 is a non-enhancer of phenotype of rlSem

lilliXS575 is a non-enhancer of phenotype of aopS2382

lilliXS575 is a non-enhancer of phenotype of sevS11.Tag:MYC

lilliXS575 is a non-enhancer of phenotype of phylsev.PC

lilliXS575 is a non-enhancer of phenotype of Ras85DN17.sev

Suppressor of
Statement
Reference

lilliXS575 is a suppressor of phenotype of ttk88.hs.sev.Tag:MYC

lilliXS575 is a suppressor of phenotype of Pi3K92EDN.GMR

lilliXS575 is a suppressor of ommatidium phenotype of ttk88.GMR.Tag:MYC

lilliXS575 is a suppressor of ommatidium phenotype of aopACT.GMR

lilliXS575 is a suppressor of phenotype of Raf::tor12D.hs.sev

lilliXS575 is a suppressor of ommatidium phenotype of sinaGMR.PN

lilliXS575 is a suppressor of ommatidium phenotype of phylGMR.PC

lilliXS575 is a suppressor of phenotype of rprGMR.PH

lilliXS575 is a suppressor of phenotype of Pi3K92Ewt.GMR

lilliXS575 is a suppressor of phenotype of Pi3K92EACT.GMR

lilliXS575 is a suppressor of phenotype of Ras85DV12.GMR

lilliXS575 is a suppressor of phenotype of phylhs.sev

lilliXS575 is a suppressor of phenotype of Rho1GMR.PH

NOT Suppressor of
Statement
Reference

lilliXS575 is a non-suppressor of phenotype of aopACT.sev

lilliXS575 is a non-suppressor of phenotype of rlSem.sev

lilliXS575 is a non-suppressor of phenotype of rlSem

lilliXS575 is a non-suppressor of phenotype of aopS2382

lilliXS575 is a non-suppressor of phenotype of sevS11.Tag:MYC

lilliXS575 is a non-suppressor of phenotype of phylsev.PC

lilliXS575 is a non-suppressor of phenotype of Ras85DN17.sev

lilliXS575 is a non-suppressor of phenotype of Nact.sev

Additional Comments
Genetic Interactions
Statement
Reference

A lilliXS575 heterozygous background gives a dominant moderate enhancement to the ato1090/Df(3R)p13 eye phenotype at 25[o]C.

runScer\UAS.cLa (Scer\GAL4nos.PG) embryos that are also heterozygous for lilliXS575 show a significant increase in viability from approximately 3% to approximately 51%.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)