FlyBase Allele Report: Scer\GAL4[neur-P72]

neur, bib and fng reporter expression was observed during the formation of ball-and-socket joints in the leg. These drivers are expressed in different but overlapping cell populations in the developing joint. bib and neur are expressed in the deep region of the cavity, flanked by fng expression in cells projecting into the ridge and cells on the ventral side of the cavity. bib was expressed distal to neur, with an overlap of about two cells. Shortly after the onset of ball formation, bib-expressing cells are in contact with the ball cuticle. The expression of neur appears to overlap largely with bib-expressing cells and to extend dorsally to them. bib and neur expression domains are four to six cells wide along the anteroposterior axis. When the ball has fully grown, the apical surfaces of bib-expressing cells comes into contact with the ventral side of the ball, and then the apical surfaces further shifted distally, eventually contacting the newly formed lip. Consistently, the apices of the ventral portion of neur-expressing cells (co-expressing bib) relocate to the ventral side of the ball, and the apical surfaces of their dorsal subsets move with the edge of the extending socket, until covering the ventral part of the socket. Meanwhile, the dorsal fng-expressing cells expand their apical surfaces, and when the socket cuticle forms at the bottom of the cavity, they

(Tajiri et al., 2010)

cover a large dorsal portion of the socket cuticle. Live imaging was used to follow the bib- and neur-expressing cells.

(Tajiri et al., 2010)

Marker for

external sensory organ precursor cell I

(Bellaiche et al., 2001)

Reflects expression of

neur

(Tajiri et al., 2010, Bellaiche et al., 2001)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | larval stage, with tll^GD1548

(Apitz and Salecker, 2015)

abnormal cell polarity, with insc^UAS.cKa

(Bellaiche et al., 2001)

abnormal cell polarity | larval stage, with Disc\RFP^HMS05713, baz^mScarlet

(Loyer et al., 2024)

abnormal cell polarity | larval stage, with Disc\RFP^HMS05713, baz^{S180A.UASz.Tag:polyHis,EGFP}, baz^mScarlet

(Loyer et al., 2024)

abnormal cell polarity | larval stage, with Disc\RFP^HMS05713, baz^{S180D.UASz.Tag:polyHis,EGFP}, baz^mScarlet

(Loyer et al., 2024)

abnormal cytokinesis, with Rho1^N19.UAS

(Emery et al., 2005)

abnormal mitotic cell cycle, with dap^UAS.cLa

(Remaud et al., 2008, Audibert et al., 2005)

abnormal mitotic cell cycle | third instar larval stage, with Cdk1^{T14A.Y15F.UASp.Venus}

(Ayeni et al., 2014)

abnormal mitotic cell cycle | third instar larval stage, with Cdk1^{Y15F.UASp.Venus}

(Ayeni et al., 2014)

abnormal smell perception | adult stage, with Osi23^GD3128

(Ando et al., 2019)

abnormal smell perception | adult stage, with Osi23^KK103932

(Ando et al., 2019)

decreased occurrence of cell division, with CycE^UAS.cLa

(Audibert et al., 2005)

decreased occurrence of cell division | P-stage, with geminin^UAS.cQa

(Remaud et al., 2008)

increased occurrence of cell division | larval stage, with Cdk1^{T14A.Y15F.UASp.Venus}

(Ayeni et al., 2014)

lethal, with Osi9^NIG.15592R

(Sun et al., 2024)

lethal, with Osi20^NIG.15188R

(Sun et al., 2024)

lethal, with Osi21^HMJ23686

(Sun et al., 2024)

viable, with Osi1^GD2817

(Sun et al., 2024)

viable, with Osi3^GD2819

(Sun et al., 2024)

viable, with Osi4^KK103185

(Sun et al., 2024)

viable, with Osi4^NIG.10303R

(Sun et al., 2024)

viable, with Osi6^GD2821

(Sun et al., 2024)

viable, with Osi6^NIG.1151R

(Sun et al., 2024)

viable, with Osi7^KK105155

(Sun et al., 2024)

viable, with Osi8^NIG.15591R

(Sun et al., 2024)

viable, with Osi9^KK107148

(Sun et al., 2024)

viable, with Osi10a^KK106318

(Sun et al., 2024)

viable, with Osi11^KK112294

(Sun et al., 2024)

viable, with Osi11^NIG.15596R

(Sun et al., 2024)

viable, with Osi12^NIG.1154R

(Sun et al., 2024)

viable, with Osi13^GD3625

(Sun et al., 2024)

viable, with Osi13^NIG.15595R

(Sun et al., 2024)

viable, with Osi14^KK112962

(Sun et al., 2024)

viable, with Osi14^NIG.1155R

(Sun et al., 2024)

viable, with Osi15^KK109781

(Sun et al., 2024)

viable, with Osi17^GD3626

(Sun et al., 2024)

viable, with Osi18^GD2831

(Sun et al., 2024)

viable, with Osi18^KK110564

(Sun et al., 2024)

viable, with Osi18^NIG.1169R

(Sun et al., 2024)

viable, with Osi19^KK112492

(Sun et al., 2024)

viable, with Osi21^GD1086

(Sun et al., 2024)

viable, with Osi23^GD3128

(Sun et al., 2024)

viable, with Osi23^KK103932

(Sun et al., 2024)

viable, with Osi24^GD9064

(Sun et al., 2024)

visible, with E(spl)m4-BFM^UAS.Tag:FLAG

(Fontana and Posakony, 2009)

visible, with IKKε^GS11377

(Otani et al., 2011)

visible, with IKKε^UAS.EGFP

(Otani et al., 2011)

visible, with IKKε^UAS.Tag:MYC

(Otani et al., 2011)

visible, with l(2)gd1^UAS.cGa

(Gallagher and Knoblich, 2006)

visible, with l(2)gd1^ΔC2.C.UAS

(Gallagher and Knoblich, 2006)

visible | adult stage, with spn-F^UAS.FL.EGFP

(Otani et al., 2015)

Phenotype Manifest In

adult cuticle, with Rab5^{Q88L.UAS.EGFP}

(Coumailleau et al., 2009)

adult head bristle | ectopic, with E(spl)m4-BFM^UAS.Tag:FLAG

(Fontana and Posakony, 2009)

adult optic lobe neuron, with tll^GD1548

(Apitz and Salecker, 2015)

basal part of cell | larval stage, with Disc\RFP^HMS05713, baz^{S180A.UASz.Tag:polyHis,EGFP}, baz^mScarlet

(Loyer et al., 2024)

basal part of cell | larval stage, with Disc\RFP^HMS05713, baz^{S180D.UASz.Tag:polyHis,EGFP}, baz^mScarlet

(Loyer et al., 2024)

centrosome, with Cdk5^KK109344

(Jauffred et al., 2013)

centrosome, with CRMP^VDRC.cUa

(Jauffred et al., 2013)

centrosome, with DCTN1-p150^Δ.UAS

(Jauffred et al., 2013)

centrosome, with numb^{fl.UAS.Tag:MYC}

(Jauffred et al., 2013)

centrosome, with Rab11^KK108297

(Jauffred et al., 2013)

chaeta, with IKKε^GS11377

(Otani et al., 2011)

chaeta, with IKKε^UAS.EGFP

(Otani et al., 2011)

chaeta, with IKKε^UAS.Tag:MYC

(Otani et al., 2011)

cuticular pore | adult stage, with Osi23^GD3128

(Ando et al., 2019)

cuticular pore | adult stage, with Osi23^KK103932

(Ando et al., 2019)

early endosome, with l(2)gd1^UAS.cGa

(Gallagher and Knoblich, 2006)

endosome, with l(2)gl^3A.UAS

(Coumailleau et al., 2009)

endosome, with Rab5^{Q88L.UAS.EGFP}

(Coumailleau et al., 2009)

eo sensory structure | adult stage, with Osi23^GD3128

(Ando et al., 2019)

eo sensory structure | adult stage, with Osi23^KK103932

(Ando et al., 2019)

external sensory organ, with l(2)gd1^UAS.cGa

(Gallagher and Knoblich, 2006)

external sensory organ, with l(2)gd1^ΔC2.C.UAS

(Gallagher and Knoblich, 2006)

external sensory organ, with numb^{4A.UAS.Tag:MYC}

(Smith et al., 2007)

external sensory organ, with numb^{5A.UAS.Tag:MYC}

(Smith et al., 2007)

external sensory organ, with numb^{S52A.UAS.Tag:MYC}

(Smith et al., 2007)

external sensory organ precursor cell, with Elp1^KK100227

(Planelles-Herrero et al., 2022)

external sensory organ precursor cell, with Elp2^KK100697

(Planelles-Herrero et al., 2022)

external sensory organ precursor cell, with Elp3^NIG.15433R

(Planelles-Herrero et al., 2022)

external sensory organ precursor cell, with Rho1^N19.UAS

(Emery et al., 2005)

external sensory organ precursor cell I, with Cdk5^KK109344

(Jauffred et al., 2013)

external sensory organ precursor cell I, with CRMP^VDRC.cUa

(Jauffred et al., 2013)

external sensory organ precursor cell I, with DCTN1-p150^Δ.UAS

(Jauffred et al., 2013)

external sensory organ precursor cell I, with insc^UAS.cKa

(Bellaiche et al., 2001)

external sensory organ precursor cell I, with numb^{fl.UAS.Tag:MYC}

(Jauffred et al., 2013)

external sensory organ precursor cell I, with Rab11^KK108297

(Jauffred et al., 2013)

external sensory organ precursor cell I, with trbl^UAS.cMb

(Fichelson and Gho, 2004)

external sensory organ precursor cell IIa | increased number, with Rab5^{Q88L.UAS.EGFP}

(Coumailleau et al., 2009)

external sensory organ precursor cell IIb, with Rab5^{Q88L.UAS.EGFP}

(Coumailleau et al., 2009)

G1 phase & external sensory organ precursor cell IIa, with dap^UAS.cLa

(Audibert et al., 2005)

G1 phase & external sensory organ precursor cell IIb, with dap^UAS.cLa

(Audibert et al., 2005)

G1 phase & external sensory organ precursor cell IIIb, with CycE^UAS.cLa

(Audibert et al., 2005)

larval inner optic anlage, with tll^GD1548

(Apitz and Salecker, 2015)

larval neuroblast, with Disc\RFP^HMS05713, baz^mScarlet

(Loyer et al., 2024)

larval neuroblast, with Disc\RFP^HMS05713, baz^{S180A.UASz.Tag:polyHis,EGFP}, baz^mScarlet

(Loyer et al., 2024)

larval neuroblast, with Disc\RFP^HMS05713, baz^{S180D.UASz.Tag:polyHis,EGFP}, baz^mScarlet

(Loyer et al., 2024)

macrochaeta, with jvl^GD11011

(Dubin-Bar et al., 2011)

macrochaeta, with spn-F^GD7489

(Dubin-Bar et al., 2011)

macrochaeta, with trbl^UAS.cMb

(Fichelson and Gho, 2004)

macrochaeta, with trc^S292A.UAS.L

(He et al., 2005)

macrochaeta, with trc^{S292A+T453A.UAS.L}

(He et al., 2005)

macrochaeta, with trc^T453A.UAS.L

(He et al., 2005)

macrochaeta | ectopic, with E(spl)m4-BFM^UAS.Tag:FLAG

(Fontana and Posakony, 2009)

maxillary palp basiconic sensillum, with Osi23^GD3128

(Ando et al., 2019)

maxillary palp basiconic sensillum, with Osi23^KK103932

(Ando et al., 2019)

mesothoracic bristle, with spn-F^UAS.FL.EGFP

(Otani et al., 2015)

mesothoracic tergum & microchaeta, with Hsap\EZR^{1-280.UAS.GFP}

(De Joussineau et al., 2003)

polar follicle cell | increased number, with BacA\p35^UAS.cHa

(Besse and Pret, 2003)

polar follicle cell | increased number, with Delta^UAS.cHa

(Assa-Kunik et al., 2007)

sensory mother cell, with l(2)gl^3A.UAS

(Coumailleau et al., 2009)

sensory mother cell, with Rab5^{Q88L.UAS.EGFP}

(Coumailleau et al., 2009)

sensory mother cell, with shg^{dCPc3.UAS.sgGFP}

(Le Borgne et al., 2002)

sensory mother cell & filopodium, with Delta^UAS.cHa

(De Joussineau et al., 2003)

sensory mother cell & filopodium, with Hsap\EZR^{1-280.UAS.GFP}

(De Joussineau et al., 2003)

sensory mother cell | increased number, with Tom^UAS.cLa

(Bardin and Schweisguth, 2006)

sensory mother cell | third instar larval stage, with Cdk1^{T14A.Y15F.UASp.Venus}

(Ayeni et al., 2014)

sensory mother cell | third instar larval stage, with Cdk1^{Y15F.UASp.Venus}

(Ayeni et al., 2014)

sensory neuron | increased number, with Tom^UAS.cLa

(Bardin and Schweisguth, 2006)

spindle midzone, with Elp1^KK100227

(Planelles-Herrero et al., 2022)

spindle midzone, with Elp2^KK100697

(Planelles-Herrero et al., 2022)

spindle midzone, with Elp3^NIG.15433R

(Planelles-Herrero et al., 2022)

stalk follicle cell, with upd1^UAS.cCa

(Assa-Kunik et al., 2007)

stalk follicle cell | increased number, with Kul^RNAi.UAS.pro

(Assa-Kunik et al., 2007)

thecogen cell, with CycE^UAS.cLa

(Audibert et al., 2005)

tormogen cell, with CycE^UAS.cLa

(Audibert et al., 2005)

tormogen cell, with neur^UAS.cLa

(Le Borgne and Schweisguth, 2003)

tormogen cell, with trbl^UAS.cMb

(Fichelson and Gho, 2004)

trichogen cell, with neur^UAS.cLa

(Le Borgne and Schweisguth, 2003)

trichogen cell, with trbl^UAS.cMb

(Fichelson and Gho, 2004)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

CycE^UAS.cLa, Scer\GAL4^neur-P72 has decreased occurrence of cell division phenotype, suppressible by dap[+]/dap⁴

(Audibert et al., 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^neur-P72, trbl^UAS.cMb has trichogen cell phenotype, suppressible | heat sensitive by N^icd.hs

(Fichelson and Gho, 2004)

Suppressor of

Statement

Reference

Scer\GAL4^neur-P72/CycE^UAS.cLa is a suppressor of PNS glial cell phenotype of dap⁴

(Audibert et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

80575

w^*; wg^Sp-1/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7; P{GAL4}neur^P72/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Scer\GAL4^neur-P72

neu^P72

(Bellaiche et al., 2001, Bellaiche et al., 2001)

neuralized^P72

(Tajiri et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (68)

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