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General Information
Symbol
Dmel\tutl4
Species
D. melanogaster
Name
FlyBase ID
FBal0122876
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{lacW} element resulting in deletion of tutl sequences. The deletion extends into CG16857.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Lethal stage is during pre-eclosion. General morphology of the mutant larvae is normal. Mutant larvae respond to tactile stimulation at their anterior end by contracting at both ends and rocking back and forth in place. After a few seconds of this behaviour, the larvae cease this abnormal movement and return to a normal forward-crawling motion. This contrasts with wild-type larvae which respond by showing a characteristic escape behaviour of 1-3 reverse peristaltic movements followed by a lateral turning behaviour. Homozygous and tutl4/Df(2L)ed-dp larvae have a severely compromised ability to roll over from an inverted position; the time required to right themselves is significantly (nearly 20-fold) longer than control larvae. The rate of executing peristaltic contractions during normal locomotion is slightly reduced (less than 15%) in homozygous larvae compared to wild type. Homozygous embryos show no abnormalities in the morphology of the longitudinal tracts or the anterior and posterior commissures. No transient defects in axonal patterning have been detected through stages 9 to 17. Brain morphology and size and shape of the axon scaffold appears normal. No abnormalities in the Fas2-positive longitudinal connectives or in the motor axon pathways that exit the CNS to innervate the musculature are seen. The ventral unpaired median axons and segmental and intersegmental nerves also appear normal. No defects in the PNS have been detected. The longitudinal connectives appear normal in third instar mutant larvae. Muscle innervation and presynaptic morphology at the neuromuscular junction (NMJ) appears normal. The kinetics and amplitude of the excitatory junctional currents (EJCs) at the NMJ are not significantly different from wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)