FlyBase Allele Report: Dmel\dsh[UAS.Tag:MYC]

General Information

Symbol

Dmel\dsh^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0138246

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

P{UAS-dsh.myc}

Also Known As

UAS-dsh, UAS-dsh-myc, UAS-Dsh:Myc

Key Links

Transgenic product class

wild_type

(Penton et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Penton et al., 2002)

Mutagen

in vitro construct

(Penton et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-dsh.myc}

Cytology

Description

UASt regulatory sequences drive expression of dsh tagged at the C-terminus with Tag:MYC.

(Penton et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsh

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.1N4R

(Folwell et al., 2010)

ameliorates neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures

modeled by Hsap\IRF2BPL^UAS.cBa

(Marcogliese et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^tap-Gal4

(Yuan et al., 2016)

abnormal planar polarity, with Scer\GAL4^69B

(Penton et al., 2002)

abnormal planar polarity, with Scer\GAL4^ap-md544

(Capilla et al., 2012)

visible, with Scer\GAL4^69B

(Penton et al., 2002)

visible, with Scer\GAL4^GMR.PF

(Penton et al., 2002)

visible | adult stage, with Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Phenotype Manifest In

adult mushroom body beta-lobe | adult stage, with Scer\GAL4^tap-Gal4

(Yuan et al., 2016)

axon | adult stage, with Scer\GAL4^tap-Gal4

(Yuan et al., 2016)

eye, with Scer\GAL4^GMR.PF

(Penton et al., 2002)

leg, with Scer\GAL4^ap-md544

(Capilla et al., 2012)

leg joint, with Scer\GAL4^ap-md544

(Capilla et al., 2012)

wing, with Scer\GAL4^69B

(Penton et al., 2002)

wing, with Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

wing hair | ectopic, with Scer\GAL4^bbg-C96

(Marcetteau et al., 2021)

wing hair | ectopic, with Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

wing margin bristle | ectopic, with Scer\GAL4^69B

(Penton et al., 2002)

wing vein, with Scer\GAL4^69B

(Penton et al., 2002)

Detailed Description

Statement

Reference

The expression of dsh^UAS.Tag:MYC under the control of Scer\GAL4^nub-AC-62 induces wing blisters and ectopic wing bristles.

(Marcogliese et al., 2022)

The expression of dsh^UAS.Tag:MYC under the control of Scer\GAL4^bbg-C96 induces ectopic wing blade bristles.

(Marcetteau et al., 2021)

Expression of dsh^{Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^tap-Gal4 results in a significant increase in the frequency of mild and severe mushroom body beta lobe axon midline crossing defects (no significant effect on frequency of missing alpha lobes) compared to wild type.

(Yuan et al., 2016)

Expression of dsh^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ap-md544 results in defects in planar polarity in the leg and the joint between tarsal segments T4 and T5 is absent.

(Capilla et al., 2012)

Adults expressing dsh^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF have reduced eyes. Surviving flies expressing dsh^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^69B have ectopic mechanosensory bristles near the wing margin, severe vein and planar polarity defects and in some cases have wing blisters.

(Penton et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^nub-AC-62, dsh^UAS.Tag:MYC has visible | adult stage phenotype, suppressible | partially by Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Scer\GAL4^69B, dsh^UAS.Tag:MYC has visible phenotype, suppressible by Axn^16-21

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has visible phenotype, suppressible by Axn^16-21

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has visible phenotype, suppressible by Axn^8-66

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has visible phenotype, suppressible by M(UAS-dsh)8-3^8-3

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has visible phenotype, suppressible by M(UAS-dsh)8-4^8-4

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has visible phenotype, suppressible by Axn^8-13

(Penton et al., 2002)

Suppressor of

Statement

Reference

dsh^UAS.Tag:MYC, Scer\GAL4^unspecified is a suppressor of abnormal locomotor behavior | progressive phenotype of Hsap\MAPT^UAS.1N4R, Scer\GAL4^unspecified

(Folwell et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^nub-AC-62, dsh^UAS.Tag:MYC has wing phenotype, suppressible | partially by Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Scer\GAL4^nub-AC-62, dsh^UAS.Tag:MYC has wing hair | ectopic phenotype, suppressible | partially by Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Scer\GAL4^bbg-C96, dsh^UAS.Tag:MYC has wing hair | ectopic phenotype, suppressible | partially by Arf6^GX16w-/Arf51F[+]

(Marcetteau et al., 2021)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has eye phenotype, suppressible by M(UAS-dsh)8-4^8-4

(Penton et al., 2002)

Scer\GAL4^69B, dsh^UAS.Tag:MYC has wing phenotype, suppressible by Axn^16-21

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has eye phenotype, suppressible by Axn^16-21

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has eye phenotype, suppressible by Axn^8-13

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has eye phenotype, suppressible by Axn^8-66

(Penton et al., 2002)

Scer\GAL4^GMR.PF, dsh^UAS.Tag:MYC has eye phenotype, suppressible by M(UAS-dsh)8-3^8-3

(Penton et al., 2002)

Enhancer of

Statement

Reference

Scer\GAL4^bbg-C96/dsh^UAS.Tag:MYC is an enhancer of mechanosensory medial triple row bristle | decreased number phenotype of Arf6^GX16w-

(Marcetteau et al., 2021)

dsh^UAS.Tag:MYC/Scer\GAL4^ey.PH is an enhancer of eye disc | ventral phenotype of L²

(Singh et al., 2006)

dsh^UAS.Tag:MYC/Scer\GAL4^ey.PH is an enhancer of eye | ventral phenotype of L²

(Singh et al., 2006)

Suppressor of

Statement

Reference

Scer\GAL4^unspecified/dsh^UAS.Tag:MYC is a suppressor of embryonic/larval motor neuron phenotype of Hsap\MAPT^UAS.1N4R, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Scer\GAL4^unspecified/dsh^UAS.Tag:MYC is a suppressor of axon phenotype of Hsap\MAPT^UAS.1N4R, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

dsh^UAS.Tag:MYC, Scer\GAL4^bbg-C96 is a suppressor of wing margin phenotype of Hrs^UAS.cLa, Scer\GAL4^bbg-C96

(Seto and Bellen, 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of dsh^{Scer\UAS.T:Hsap\MYC} does not suppress the wing notching seen when Klp64D^NIG.10642R is expressed under the control of Scer\GAL4^bbg-C96.

(Vuong et al., 2014)

Expression of dsh^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey.PH leads to an enhancement of the ventral eye loss phenotype of L²/+ flies.

(Singh et al., 2006)

Xenogenetic Interactions

Statement

Reference

Co-expression of dsh^{Scer\UAS.T:Hsap\MYC} with Hsap\MAPT^{Scer\UAS.1N4R} under the control of Scer\GAL4^unspecified suppresses the axonal transport defects and locomotor impairments induced by the expression of Hsap\MAPT^{Scer\UAS.1N4R} alone.

(Folwell et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

9453

w^*; P{UAS-dsh.myc}1-16

9520

w¹¹⁸; P{UAS-dsh.myc}3-8 Axn^8-66