FB2025_01 , released February 20, 2025
Allele: Dmel\Ras85Dhs.M11.2
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General Information
Symbol
Dmel\Ras85Dhs.M11.2
Species
D. melanogaster
Name
FlyBase ID
FBal0141566
Feature type
allele
Associated gene
Dmel\Ras85D
Associated Insertion(s)
Carried in Construct
P{hs-Ras1.M11.2}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Held, 2002)
Progenitor genotype
Carried in construct
P{hs-Ras1.M11.2}
Cytology
Description

Construct: Constitutively active Ras85D is driven by a heat shock promoter.

(Held, 2002)
Allele components
Component
Use(s)
Encoded product / tool
Ras85D
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      mesothoracic tarsal segment 1 & bract | ectopic

      (Held, 2002)

      mesothoracic tibial bract | ectopic

      (Held, 2002)
      Detailed Description
      Statement
      Reference

      When Ras85Dhs.M11.2 animals are heat shocked at any time between 5 and 27 hours after pupariation (AP), their legs acquire extra bracts. On the tibia these excess bracts are patchily distributed, on the basitarsus these bracts are also patchy (found mainly near bristles) for shocks between 11 and 27 hours AP, but earlier shocks (5-10h AP) typically yield a confluent lawn of unpigmented bracts.

      (Held, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of Ras85Dhs.M11.2 under heat shock control partially suppresses the missing-bract phenotype seen in Ras85De1B/+, S05671/+ mutants.

      (Held, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Ras85Dhs.M11.2 partially rescues Ras85De1B

      (Held, 2002)
      Comments

      The addition of Ras85Dhs.M11.2 under heat shock control partially suppresses the missing-bract phenotype seen in Ras85De1B/+, S05671/+ mutants.

      (Held, 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ras85Dhs.M11.2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)