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General Information
Symbol
Dmel\ParpGMR.PU
Species
D. melanogaster
Name
glass multimer reporter construct of Uchida
FlyBase ID
FBal0144696
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression of a full length Parp cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing ParpGMR.PU have a rough eye phenotype. Ommatidia have an abnormal shape and size and ommatidial fusion is seen. The orientation of the ommatidia is disrupted; some ommatidia are rotated incorrectly and show incorrect chiral forms. A rectangular pattern of rhabdomeres is seen in some flies. The number of non-neuronal accessory cells in the eye is almost normal, although their morphology and arrangement is abnormal. The arrangement of photoreceptor clusters is slightly disordered in thid larval instar eye discs expressing ParpGMR.PU. R3/R4 cells are arranged in random orientation in each ommatidium, indicating disordered polarity. The number of apoptotic cells posterior to the morphogenetic furrow is slightly higher than normal. DNA synthesis and mitosis appear normal in these discs. The organisation of the F-actin cytoskeleton is disrupted in the eyes of 40 hour pupae expressing ParpGMR.PU; F-actin is sporadically organized at the apical surface and the spokewise pattern that is normally seen at the apical surface is almost completely absent. The normal accumulation of F-actin at the centre of the ommatidium (which is the precursor of the rhabdomere) is sometimes missing and the arrangement of the secondary and tertiary pigment cells and bristle complexes at the basal floor is also disrupted.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference

ParpGMR.PU is a suppressor | partially of visible phenotype of Rho1GMR.PH

Phenotype Manifest In
NOT suppressed by
Statement
Reference

ParpGMR.PU has ommatidium phenotype, non-suppressible by BacA\p35GMR.PH

Suppressor of
Statement
Reference

ParpGMR.PU is a suppressor | partially of ommatidium phenotype of Rho1GMR.PH

Additional Comments
Genetic Interactions
Statement
Reference

The misrotation and incorrect chirality of ommatidia seen in flies expressing ParpGMR.PU is not suppressed by co-expression of BacA\p35GMR.PH. ParpGMR.PU shows no genetic interaction with fz1/+, fz23/+, fzGMR.PA or dsh1/+. The Rho1GMR.PH phenotype is partially suppressed by ParpGMR.PU; ommatidial lattices are seen in the rescued flies and pigment cells are seen in deeper regions of the retina. A distinct rhabdomere structure also appears.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ParpGMR.PU
Name Synonyms
glass multimer reporter construct of Uchida
Secondary FlyBase IDs
    References (1)