FB2025_01 , released February 20, 2025
Allele: Dmel\PDZ-GEFΔ1
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General Information
Symbol
Dmel\PDZ-GEFΔ1
Species
D. melanogaster
Name
FlyBase ID
FBal0193630
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dizzyΔ1, dzyΔ1
Key Links
Nature of the Allele
Cytology
Description

Imprecise excision of the P{EP} element, resulting in deletion of 174bp upstream of the former insertion site.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The number of haemocytes that migrate into the tail is reduced in Gef26Δ1 and Gef26Δ1/Df(2L)BSC185 mutant embryos.

Gef26Δ1 and Gef26Δ1/Df(2L)BSC5 escapers have rough eyes that are reduced in size, wing blades that are bent downwards and distorted male genitalia.

At stage 14, the posterior part of the ventral nerve cord lacks macrophages in Gef26Δ1 mutants, whereas in wild-type embryos, the ventral nerve cord is completely surrounded by macrophages. In some mutant embryos, the resulting ventral gap persists until later stages, while in others the gap eventually disappears toward stage 15. Macrophages are found in an aberrant, dorsal position beneath the amnioserosa in mutant embryos after germ band retraction. Gef26Δ1 macrophages form smaller protrusions than in wild-type macrophages and do not achieve the even distribution seen in stage 15 wild-type embryos, resulting in the posterior-ventral part of the mutant embryo containing fewer macrophages than wild type. Other aspects of the migration, such as the migration along the dorsal epidermis, are not affected.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The number of haemocytes that migrate into the tail region is reduced in Gef26Δ1, RhoL10-161 double mutant embryos, comparable to the reduced number observed in RhoL10-161 mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)