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General Information
Symbol
Dmel\PDZ-GEFΔ7
Species
D. melanogaster
Name
FlyBase ID
FBal0193632
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{EP} element, resulting in deletion of 2253bp around the former insertion site. This removes the entire exon 0, the transcription start site and almost all of the first intron.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Gef26Δ7 and Gef26Δ7/Df(2L)BSC5 escapers have rough eyes that are reduced in size, wing blades that are bent downwards and distorted male genitalia.

At stage 14, the posterior part of the ventral nerve cord lacks macrophages in Gef26Δ7 mutants, whereas in wild-type embryos, the ventral nerve cord is completely surrounded by macrophages. In some mutant embryos, the resulting ventral gap persists until later stages, while in others the gap eventually disappears toward stage 15. Macrophages are found in an aberrant, dorsal position beneath the amnioserosa in mutant embryos after germ band retraction. Gef26Δ7 macrophages form smaller protrusions than in wild-type macrophages and do not achieve the even distribution seen in stage 15 wild-type embryos, resulting in the posterior-ventral part of the mutant embryo containing fewer macrophages than wild type. Other aspects of the migration, such as the migration along the dorsal epidermis, are not affected.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Gef26Δ7
PDZ-GEFΔ7
Name Synonyms
Secondary FlyBase IDs
    References (1)