FB2026_02 , released June 18, 2026
Allele: Dmel\Gr63a1
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General Information
Symbol
Dmel\Gr63a1
Species
D. melanogaster
Name
FlyBase ID
FBal0193768
Feature type
allele
Associated gene
Dmel\Gr63a
Associated Insertion(s)
TI{TI}Gr63a1
Carried in Construct
Also Known As
ΔGr63a
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Jones et al., 2007)
Mutagen
recombination
(Jones et al., 2007)
I-SceI
(Jones et al., 2007)
FLPase
(Jones et al., 2007)
ends-out gene targeting
(Jones et al., 2007)
Progenitor genotype
Associated Insertion(s)
TI{TI}Gr63a1
Cytology
Description

The entire Gr63a gene has been replaced by a w+* marker.

(Jones et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Gr63a1 homozygotes do not show avoidance to CO2, unlike wild-type and heterozygous controls.

      (Badsha et al., 2012)

      Female Gr63a1 homozygotes have up to a 30% increase in lifespan compared to controls. The lifespan of male homozygotes does not differ from wild type. Heterozygous Gr63a1 females have a similar lifespan to controls.

      Gr63a1 homozygous females are of similar weight and size to controls and contain a similar level of proteins. However triglyceride levels are elevated in homozygous Gr63a1 females compared to wild type. No change in triglyceride levels is observed in heterozygotes.

      Female Gr63a1 homozygous mutants do not show an increase in lifespan under starvation conditions compared to wild type.

      Female Gr63a1 mutants lay approximately 40% more eggs over a two week period than control flies.

      Female Gr63a1 flies show increased oxidative stress resistance compared to wild type females (when exposed to methyl viologen). No difference from wild type is seen in heterozygous flies.

      No changes in circadian rhythm or activity levels are seen in Gr63a1 mutants. A reduction in sleep is observed but is not reproducible in all experiments (seen in 1 out of 3).

      Dietary restriction enhances the increase longevity phenotype seen in female Gr63a1 mutants. The magnitude of the increase is similar to the increase in longevity seen in dietary restricted wild type flies. There is no evidence of alteration to food consumption levels in Gr63a1 female flies compared to controls.

      Gr63a1 female mutants are less able to detect live yeast than control flies. Unlike wild type flies Gr63a1 mutants do not show a preference for live yeast over autoclaved yeast.

      Unlike in wild type, Gr63a1 mutants do not exhibit a reduction in lifespan in response to the odour of live yeast, and in one out of four experiments lifespan slightly increases compared to controls. No alteration to lifespan occurs in either wild type or Gr63a1 flies when they are exposed to yeast killed by autoclaving.

      (Poon et al., 2010)

      Electrophysiological recordings of ab1 sensilla in Gr63a1 flies reveal a complete indifference to CO2 stimuli, while ab1C neurons in wild-type flies do respond to CO2. This phenotype is not seen in Gr63a1/+ flies. Further, Gr63a1 flies fail to avoid CO2 in a T maze, while Gr63a1/+ flies show a wild-type behavioral response to CO2.

      (Jones et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of both Gr63aScer\UAS.cJa and Gr21aScer\UAS.cJa under the control of Scer\GAL4Ir64a.PA in Ir64aMB05283, Gr63a1 double mutant flies allows artificial stimulation of DC4 dorsal glomeruli of the adult antennal lobe by 5% CO[[2]] and robust avoidance of CO[[2]] in behavioural experiments. However, DP1m neurons are not activated by CO[[2]] in these mutants.

      Behavioural experiments demonstrate that Gr63a1; Ir64aMB05283 double mutant flies fail to distinguish ambient air from 5% CO[[2]].

      (Ai et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Gr63a1 is rescued by Gr63aUAS.cJa/Scer\GAL4Gr63a.PF

      (Poon et al., 2010)
      Partially rescued by

      Gr63a1 is partially rescued by Scer\GAL4Gr21a.9.323/Gr63aUAS.cJa

      (Jones et al., 2007)
      Comments

      Expression of Gr63aScer\UAS.cJa under the control of the native promoter (Scer\GAL4[Gr63a.PF]) restores the increased lifespan phenotype of Gr63a1 females to wild type levels.

      Expression of Gr63aScer\UAS.cJa under the control of the Scer\GAL4Gr63a.PF driver rescues the high triglyceride level phenotype seen in Gr63a1 female mutants.

      (Poon et al., 2010)

      Expression of Gr63aScer\UAS.cJa under the control of Scer\GAL4Gr21a.9.323 rescues the ability of ab1C neurons to respond to CO2 in Gr63a1 flies and partially rescues the ability of Gr63a1 flies to avoid CO2 in a T-maze.

      (Jones et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (12)