FlyBase Allele Report: Dmel\yki[B5]

General Information

Symbol

Dmel\yki^B5

Species

D. melanogaster

Name

FlyBase ID

FBal0194179

Feature type

allele

Associated gene

Dmel\yki

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Oh and Irvine, 2008, Bennett and Harvey, 2006, Emoto et al., 2006)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by ft⁸

(Napoletano et al., 2011)

ameliorates cancer

modeled by scrib¹

(Bunker et al., 2015)

modeled by Ras85D^V12.UAS, Rox8^GD11645

(Guo et al., 2020)

ameliorates brain cancer

modeled by l(3)mbt^GM76

(Richter et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell size | somatic clone

(Nolo et al., 2006)

abnormal size | larval stage (with yki^AcidA)

(Xu et al., 2018)

abnormal size | larval stage | somatic clone

(Xu et al., 2018)

abnormal size | somatic clone

(Zhang et al., 2009)

decreased cell number | germline clone | oogenesis

(Zhang et al., 2024)

decreased cell number | somatic clone

(Oh and Irvine, 2011)

decreased cell size | oogenesis | somatic clone

(Venugopal et al., 2020)

decreased occurrence of cell division | larval stage

(Wada et al., 2021)

lethal

(Oh and Irvine, 2008)

lethal (with yki^E271K)

(Wu et al., 2008)

lethal (with yki^F351I)

(Wu et al., 2008)

lethal (with yki^G347R)

(Wu et al., 2008)

lethal (with yki^P88L)

(Wu et al., 2008)

lethal (with yki^P295S)

(Wu et al., 2008)

lethal (with yki^R310X)

(Wu et al., 2008)

lethal (with yki^Y282N)

(Wu et al., 2008)

lethal - all die before end of larval stage | recessive

(Li et al., 2015)

lethal - all die before end of pupal stage (with yki^AcidA)

(Xu et al., 2018)

neoplasia | adult stage | female, with yki^hs.PW

(Li et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

yki^B5 wing discs clones occupy a severely smaller disc area than control clones.

(Xu et al., 2018)

yki^B5 heterozygotes do not show obvious defects in larval or blood-brain barrier, larval subperineurial glial cell ploidy or nucleus size, or larval brain volume, as compared to controls.

(Li et al., 2017)

yki^B5 homozygous mutant embryos do not display any significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage.

(Keder et al., 2015)

yki^B5 homozygous mutants - rescued with heat-shock induced expression of yki^hs.PW every 2 days until adulthood as otherwise larval lethal - display tumorous female germaria.

(Li et al., 2015)

yki^B5 mutant eye disc clones grow poorly, comprising only 1.4% of the tissue.

yki^B5 mutant clones are hard to recover in stage 7 egg chambers, and cannot be recovered beyond stage 7.

(Koontz et al., 2013)

yki^B5 mutant wing disc clones cannot be recovered.

(Oh and Irvine, 2011)

Homozygous clones in the eye disc are very small.

(Morrison and Halder, 2010)

Wing disc clones mutant for yki^B5 are very small in size. Adjacent wild-type clones grow significantly more than control sibling clones.

(Neto-Silva et al., 2010)

yki^B5 mutant MARCM clones are comparable to wild-type cell clones.

(Ren et al., 2010)

Homozygous clones are rarely recovered in the wing disc and are small.

(Oh and Irvine, 2009, Oh and Irvine, 2008)

yki^B5 mutant eye disc clones grow poorly compared to controls.

(Zhang et al., 2009)

Homozygous clones in the eye disc are smaller than their wild-type twin spots. Homozygous clones are rarely recovered in third larval instar wing discs.

(Wu et al., 2008)

Eye and wing imaginal discs heterozygous for yki^B5 are normal in size and morphology and are indistinguishable from wild-type discs.

(Bennett and Harvey, 2006)

yki^B5 mutant clones in the anterior of the wing disc grow poorly and are very small.

(Nolo et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/puc^UAS.cMa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by Tak1[+]/Tak1¹

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by hep[+]/hep^r75

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by bsk¹/bsk[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by egr¹/egr[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/grnd^KK109939

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by Scer\GAL4^en.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^en.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by Scer\GAL4^en.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible by Scer\GAL4^nub.PU/RpS3^UAS.cAa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible by Scer\GAL4^nub.PU/RpS3^UAS.cAa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible by Scer\GAL4^en.PU/RpS3^UAS.cAa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible by Scer\GAL4^en.PU/RpS3^UAS.cAa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/Dronc^{C318G.UAS.EGFP}

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/Dronc^{C318G.UAS.EGFP}

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/puc^UAS.cMa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by bsk¹/bsk[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by hep[+]/hep^r75

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by egr¹/egr[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by Tak1[+]/Tak1¹

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by grnd^GD12580/Scer\GAL4^nub.PU

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/grnd^KK109939

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/grnd^KK109939

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by hep[+]/hep^r75

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by bsk¹/bsk[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/puc^UAS.cMa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by Tak1[+]/Tak1¹

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by egr¹/egr[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype, suppressible | partially by grnd^GD12580/Scer\GAL4^nub.PU

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype, suppressible | partially by grnd^GD12580/Scer\GAL4^nub.PU

(Wada et al., 2021)

yki^B5 has abnormal cell size | somatic clone phenotype, suppressible | partially by Scer\GAL4^hh-Gal4/mir-ban^EP3622

(Nolo et al., 2006)

NOT suppressed by

Statement

Reference

yki^B5 has decreased cell number | somatic clone phenotype, non-suppressible by Scer\GAL4^FRT.Act5C/tkv^{Q253D.UAS.cNc}

(Oh and Irvine, 2011)

Enhancer of

Statement

Reference

yki[+]/yki^B5 is an enhancer of increased cell death | larval stage phenotype of RpS3^Plac92

(Wada et al., 2021)

yki[+]/yki^B5 is an enhancer of abnormal size | adult stage phenotype of Hsap\LATS1^UAS.s, Scer\GAL4^en.PU

(Matsui et al., 2019)

yki^B5/yki^B5 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of mats^e03077

(Keder et al., 2015)

yki[+]/yki^B5 is an enhancer of visible phenotype of sd^ETX4

(Wu et al., 2008)

yki[+]/yki^B5 is an enhancer of abnormal size phenotype of Scer\GAL4^GMR.PF, sd^UAS.cSa

(Wu et al., 2008)

yki[+]/yki^B5 is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, sd^UAS.cSa

(Wu et al., 2008)

yki[+]/yki^B5 is an enhancer of abnormal size phenotype of Scer\GAL4^vg.PU, sd^UAS.cSa

(Wu et al., 2008)

yki[+]/yki^B5 is an enhancer of visible phenotype of Scer\GAL4^vg.PU, sd^UAS.cSa

(Wu et al., 2008)

NOT Enhancer of

Statement

Reference

yki[+]/yki^B5 is a non-enhancer of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-enhancer of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-enhancer of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Suppressor of

Statement

Reference

yki^B5/yki^B5 is a suppressor of increased size | somatic clone phenotype of EMC3^GD1074, Scer\GAL4^unspecified

(Shi et al., 2023)

yki[+]/yki^B5 is a suppressor | partially of increased occurrence of cell division | larval stage phenotype of RpS3^Plac92

(Wada et al., 2021)

yki[+]/yki^B5 is a suppressor of neoplasia | somatic clone | larval stage phenotype of Ras85D^V12.UAS, Rox8^GD11645, Scer\GAL4^Act.PU

(Guo et al., 2020)

yki^B5/yki^B5 is a suppressor of neoplasia | somatic clone | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei^GD3587

(Ma et al., 2020)

yki[+]/yki^B5 is a suppressor | partially of abnormal size | larval stage phenotype of mir-285^KO.w-

(Li et al., 2017)

yki^B5 is a suppressor of neoplasia | third instar larval stage phenotype of scrib¹

(Bunker et al., 2015)

yki^B5 is a suppressor of neoplasia | somatic clone phenotype of slmb^UU11

(Skwarek et al., 2014)

yki[+]/yki^B5 is a suppressor of decreased body size phenotype of Pez²/Pez¹

(Poernbacher et al., 2012)

yki[+]/yki^B5 is a suppressor of abnormal size | adult stage | somatic clone - Minute background phenotype of Df(3L)H99, mop^sfv11

(Gilbert et al., 2011)

yki[+]/yki^B5 is a suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype of ft⁸

(Napoletano et al., 2011)

yki^B5 is a suppressor of increased cell number | somatic clone phenotype of Scer\GAL4^FRT.Act5C, tkv^{Q253D.UAS.cNc}

(Oh and Irvine, 2011)

yki^B5 is a suppressor of abnormal neuroanatomy phenotype of l(3)mbt^GM76

(Richter et al., 2011)

yki[+]/yki^B5 is a suppressor of lethal - all die before end of P-stage phenotype of Scer\GAL4^GMR.PU, dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

yki[+]/yki^B5 is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

yki[+]/yki^B5 is a suppressor of lethal | pupal stage phenotype of kibra¹/kibra⁰²⁴⁰⁴

(Baumgartner et al., 2010)

yki[+]/yki^B5 is a suppressor | partially of lethal - all die before end of pupal stage phenotype of ft⁸/ft⁴²²

(Bennett and Harvey, 2006)

yki[+]/yki^B5 is a suppressor of increased cell number | somatic clone | larval stage phenotype of ft⁸

(Silva et al., 2006)

yki[+]/yki^B5 is a suppressor of increased occurrence of cell division | somatic clone | larval stage phenotype of ft⁸

(Silva et al., 2006)

yki^B5 is a suppressor of increased cell number | somatic clone phenotype of ft⁸/ft^G-rv

(Willecke et al., 2006)

NOT Suppressor of

Statement

Reference

yki[+]/yki^B5 is a non-suppressor of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-suppressor of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-suppressor of decreased cell number | somatic clone | cell non-autonomous phenotype of Apc2^g10, Apc^Q8

(Suijkerbuijk et al., 2016)

yki[+]/yki^B5 is a non-suppressor of increased cell number | somatic clone phenotype of Apc2^g10, Apc^Q8

(Suijkerbuijk et al., 2016)

yki[+]/yki^B5 is a non-suppressor of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

yki[+]/yki^B5 is a non-suppressor of visible phenotype of hid^GMR.PG

(Schoenherr et al., 2012)

Other

Statement

Reference

bam^BG, yki^B5 has cell lethal | germline clone | oogenesis phenotype

(Zhang et al., 2024)

M(2)39F¹, yki^B5 has visible | adult stage phenotype

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has visible | adult stage phenotype

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has increased cell death | larval stage phenotype

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has decreased size | adult stage phenotype

(Wada et al., 2021)

RpS26^KG00230, yki^B5 has visible | adult stage phenotype

(Wada et al., 2021)

RpS26^KG00230, yki^B5 has decreased size | adult stage phenotype

(Wada et al., 2021)

M(2)39F¹, yki^B5 has decreased size | adult stage phenotype

(Wada et al., 2021)

M(3)96C², yki^B5 has visible | adult stage phenotype

(Wada et al., 2021)

M(3)96C², yki^B5 has decreased size | adult stage phenotype

(Wada et al., 2021)

RpS17⁴, yki^B5 has visible | adult stage phenotype

(Wada et al., 2021)

RpS17⁴, yki^B5 has decreased size | adult stage phenotype

(Wada et al., 2021)

cno², yki[+]/yki^B5 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Scer\GAL4^GMR.PU, dia^{CA.UAS.Tag:HA}, yki[+]/yki^B5 has partially lethal - majority live phenotype

(Sansores-Garcia et al., 2011)

kibra⁰²⁴⁰⁴, yki[+]/yki^B5 has viable phenotype

(Baumgartner et al., 2010)

ft⁸/ft⁴²², yki[+]/yki^B5 has visible | adult stage phenotype

(Bennett and Harvey, 2006)

ft⁸/ft⁴²², yki[+]/yki^B5 has abnormal size | adult stage phenotype

(Bennett and Harvey, 2006)

Phenotype Manifest In

Suppressed by

Statement

Reference

RpS3^Plac92, yki^B5 has wing phenotype, suppressible by Scer\GAL4^nub.PU/RpS3^UAS.cAa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible by Scer\GAL4^en.PU/RpS3^UAS.cAa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by Scer\GAL4^nub.PU/Dronc^{C318G.UAS.EGFP}

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by Scer\GAL4^nub.PU/puc^UAS.cMa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by bsk¹/bsk[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by egr¹/egr[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by hep[+]/hep^r75

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by Tak1[+]/Tak1¹

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by grnd^GD12580/Scer\GAL4^nub.PU

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by Scer\GAL4^nub.PU/grnd^KK109939

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by Scer\GAL4^en.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by Scer\GAL4^nub.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype, suppressible | partially by Scer\GAL4^en.PU/Diap1^UAS.cHa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/puc^UAS.cMa

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by bsk¹/bsk[+]

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by Tak1[+]/Tak1¹

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by grnd^GD12580/Scer\GAL4^nub.PU

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by hep[+]/hep^r75

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/grnd^KK109939

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype, suppressible | partially by egr¹/egr[+]

(Wada et al., 2021)

yki^B5 has wing disc | somatic clone phenotype, suppressible | partially by Ncoa6::sd^{DB.UAS.Tag:FLAG}/Scer\GAL4^Tub.PU

(Qing et al., 2014)

yki^B5 has eye disc | somatic clone phenotype, suppressible by sd¹²

(Koontz et al., 2013)

yki^B5 has eye disc | somatic clone phenotype, suppressible by sd^del

(Koontz et al., 2013)

yki^B5 has eye disc | somatic clone phenotype, suppressible | partially by Tgi^ΔP

(Koontz et al., 2013)

yki^B5 has eye disc | somatic clone phenotype, suppressible | somatic clone by Scer\GAL4^mirr-DE/mir-ban^as.A.UAS

(Morrison and Halder, 2010)

yki^B5 has wing disc | somatic clone | cell autonomous phenotype, suppressible by Scer\GAL4^Tub.PU/Diap1^V85M.UAS

(Neto-Silva et al., 2010)

yki^B5 has wing disc | somatic clone | cell autonomous phenotype, suppressible by mir-ban^EP3622/Scer\GAL4^Tub.PU

(Neto-Silva et al., 2010)

yki^B5 has wing disc | somatic clone phenotype, suppressible by Scer\GAL4^Tub.PU/vg^UAS.cKa

(Wu et al., 2008)

yki^B5 has wing disc | somatic clone phenotype, suppressible | partially by Scer\GAL4^hh-Gal4/mir-ban^EP3622

(Nolo et al., 2006)

NOT suppressed by

Statement

Reference

yki^B5 has wing disc | somatic clone phenotype, non-suppressible by Scer\GAL4^Tub.PU/Ncoa6^UAS.cQa

(Qing et al., 2014)

yki^B5 has wing disc | somatic clone phenotype, non-suppressible by Scer\GAL4^FRT.Act5C/tkv^{Q253D.UAS.cNc}

(Oh and Irvine, 2011)

yki^B5 has wing disc | somatic clone | cell autonomous phenotype, non-suppressible by Myc^UAS.cZa/Scer\GAL4^Tub.PU/Diap1^V85M.UAS

(Neto-Silva et al., 2010)

Enhancer of

Statement

Reference

yki[+]/yki^B5 is an enhancer of wing blade posterior compartment | adult stage phenotype of Hsap\LATS1^UAS.s, Scer\GAL4^en.PU

(Matsui et al., 2019)

yki^B5/yki^B5 is an enhancer of larval RP2 motor neuron | embryonic stage phenotype of mats^e03077

(Keder et al., 2015)

yki[+]/yki^B5 is an enhancer of wing phenotype of sd^ETX4

(Wu et al., 2008)

yki[+]/yki^B5 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, sd^UAS.cSa

(Wu et al., 2008)

yki[+]/yki^B5 is an enhancer of wing phenotype of Scer\GAL4^vg.PU, sd^UAS.cSa

(Wu et al., 2008)

NOT Enhancer of

Statement

Reference

yki[+]/yki^B5 is a non-enhancer of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-enhancer of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-enhancer of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-enhancer of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki^B5 is a non-enhancer of NMJ bouton | third instar larval stage | increased number phenotype of Abca3^GD3708, Scer\GAL4^elav.PLu

(Ueoka et al., 2020)

yki[+]/yki^B5 is a non-enhancer of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

yki[+]/yki^B5 is a non-enhancer of eye photoreceptor cell phenotype of Gug^75QN.UAS, Scer\GAL4^ninaE.PT

(Napoletano et al., 2011)

Suppressor of

Statement

Reference

yki^B5/yki^B5 is a suppressor of adult midgut | somatic clone phenotype of EMC3^GD1074, Scer\GAL4^unspecified

(Shi et al., 2023)

yki[+]/yki^B5 is a suppressor of eye-antennal disc | somatic clone | larval stage phenotype of Ras85D^V12.UAS, Rox8^GD11645, Scer\GAL4^Act.PU

(Guo et al., 2020)

yki^B5/yki^B5 is a suppressor of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei^GD3587

(Ma et al., 2020)

yki[+]/yki^B5 is a suppressor | partially of perineurium | larval stage phenotype of mir-285^KO.w-

(Li et al., 2017)

yki[+]/yki^B5 is a suppressor | partially of perineurium | adult stage phenotype of mir-285^KO.w-

(Li et al., 2017)

yki[+]/yki^B5 is a suppressor of embryonic/larval CNS subperineurial glial cell | larval stage phenotype of mir-285^KO.w-

(Li et al., 2017)

yki[+]/yki^B5 is a suppressor of septate junction | larval stage phenotype of mir-285^KO.w-

(Li et al., 2017)

yki[+]/yki^B5 is a suppressor of larval brain | larval stage phenotype of mir-285^KO.w-

(Li et al., 2017)

yki[+]/yki^B5 is a suppressor | partially of nucleus | larval stage phenotype of mir-285^KO.w-

(Li et al., 2017)

yki^B5 is a suppressor of wing disc | third instar larval stage phenotype of scrib¹

(Bunker et al., 2015)

yki^B5 is a suppressor of intestinal stem cell | somatic clone phenotype of Scer\GAL4^Act.PU, Tao^GD8262

(Huang et al., 2014)

yki^B5 is a suppressor of intestinal stem cell | somatic clone phenotype of Scer\GAL4^Act.PU, Tao^RNAi.UAS.cHa

(Huang et al., 2014)

yki^B5 is a suppressor of wing disc | somatic clone phenotype of slmb^UU11

(Skwarek et al., 2014)

yki[+]/yki^B5 is a suppressor of wing disc | somatic clone phenotype of Scer\GAL4^unspecified, ptc^JF03223

(Kagey et al., 2012)

yki[+]/yki^B5 is a suppressor of eye | somatic clone - Minute background phenotype of Df(3L)H99, mop^sfv11

(Gilbert et al., 2011)

yki[+]/yki^B5 is a suppressor of head | somatic clone - Minute background phenotype of Df(3L)H99, mop^sfv11

(Gilbert et al., 2011)

yki[+]/yki^B5 is a suppressor of eye photoreceptor cell | somatic clone | progressive phenotype of ft⁸

(Napoletano et al., 2011)

yki^B5 is a suppressor of wing disc | somatic clone phenotype of Scer\GAL4^FRT.Act5C, tkv^{Q253D.UAS.cNc}

(Oh and Irvine, 2011)

yki^B5 is a suppressor of embryonic/larval optic lobe phenotype of l(3)mbt^GM76

(Richter et al., 2011)

yki[+]/yki^B5 is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

yki[+]/yki^B5 is a suppressor of eye | somatic clone phenotype of gang-of-four¹

(Beam and Moberg, 2010)

yki[+]/yki^B5 is a suppressor of wing disc | third instar larval stage phenotype of ft⁸/ft⁴²²

(Bennett and Harvey, 2006)

yki[+]/yki^B5 is a suppressor of eye disc | third instar larval stage phenotype of ft⁸/ft⁴²²

(Bennett and Harvey, 2006)

yki[+]/yki^B5 is a suppressor of eye disc | somatic clone | larval stage phenotype of ft⁸

(Silva et al., 2006)

NOT Suppressor of

Statement

Reference

yki[+]/yki^B5 is a non-suppressor of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-suppressor of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-suppressor of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki[+]/yki^B5 is a non-suppressor of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.cZa, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

yki^B5 is a non-suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Abca3^GD3708, Scer\GAL4^elav.PLu

(Ueoka et al., 2020)

yki[+]/yki^B5 is a non-suppressor of intestinal stem cell of posterior adult midgut epithelium | somatic clone | cell non-autonomous phenotype of Apc2^g10, Apc^Q8

(Suijkerbuijk et al., 2016)

yki[+]/yki^B5 is a non-suppressor of intestinal stem cell of posterior adult midgut epithelium | somatic clone phenotype of Apc2^g10, Apc^Q8

(Suijkerbuijk et al., 2016)

yki[+]/yki^B5 is a non-suppressor of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

yki[+]/yki^B5 is a non-suppressor of eye phenotype of hid^GMR.PG

(Schoenherr et al., 2012)

yki[+]/yki^B5 is a non-suppressor of eye photoreceptor cell phenotype of Gug^75QN.UAS, Scer\GAL4^ninaE.PT

(Napoletano et al., 2011)

Other

Statement

Reference

M(2)39F¹, yki^B5 has wing phenotype

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing disc | larval stage phenotype

(Wada et al., 2021)

RpS26^KG00230, yki^B5 has wing phenotype

(Wada et al., 2021)

M(3)96C², yki^B5 has wing phenotype

(Wada et al., 2021)

RpS17⁴, yki^B5 has wing phenotype

(Wada et al., 2021)

RpS3^Plac92, yki^B5 has wing phenotype

(Wada et al., 2021)

cno², yki[+]/yki^B5 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Debcl^UAS.Tag:HA, Scer\GAL4^en-e16E, yki^B5 has wing disc phenotype

(Grusche et al., 2011)

Myc^UAS.cZa, Scer\GAL4^Tub.PU, mir-ban^EP3622, yki^B5 has wing disc | somatic clone | cell autonomous phenotype

(Neto-Silva et al., 2010)

Myc^UAS.cZa, Scer\GAL4^Tub.PU, yki^B5 has wing disc | somatic clone | cell autonomous phenotype

(Neto-Silva et al., 2010)

ft⁸/ft⁴²², yki[+]/yki^B5 has eye | adult stage phenotype

(Bennett and Harvey, 2006)

ft⁸/ft⁴²², yki[+]/yki^B5 has wing | adult stage phenotype

(Bennett and Harvey, 2006)

Additional Comments

Genetic Interactions

Statement

Reference

yki^B5/+ fails to suppress the reduced growth seen in posterior midgut wild type clones when in the presence of Apc^Q8/Apc^Q8, Apc2^g10/Apc2^g10 mutant clones, and suppresses the growth of Apc^Q8/Apc^Q8, Apc2^g10/Apc2^g10 mutant clones.

(Suijkerbuijk et al., 2016)

yki^B5 heterozygosity suppresses the tumor phenotype of scrib¹ homozygous third instar larval wing discs.

(Bunker et al., 2015)

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in cno²/+;yki^B5/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

The high frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage characteristic for mats^e03077 homozygous mutant embryos is increased further by combination with yki^B5 in homozygous state.

(Keder et al., 2015)

The rough eye phenotype observed in adults expressing Magi^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PU is not modified by combination with single copy of yki^B5.

(Zaessinger et al., 2015)

yki^B5 suppresses the increase in intestinal stem cell clone size seen when Tao^GD8262 is expressed under the control of Scer\GAL4^Act.PU.

yki^B5 suppresses the increase in intestinal stem cell clone size seen when Tao^{dsRNA.shRNA.Scer\UAS} is expressed under the control of Scer\GAL4^Act.PU.

(Huang et al., 2014)

Expression of Ncoa6::sd^{DB.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^tub.PU partially suppresses the growth defect seen in yki^B5 mutant wing disc clones.

Expression of Ncoa6^Scer\UAS.cQa under the control of Scer\GAL4^tub.PU does not suppress the growth defect seen in yki^B5 mutant wing disc clones.

(Qing et al., 2014)

yki^B5 suppresses the neoplastic transformation seen in slmb^UU11 mutant wing discs.

(Skwarek et al., 2014)

sd¹² suppresses the reduction in clone growth seen in yki^B5 mutant eye discs. The clones comprise ~15% of the eye disc.

sd^del suppresses the reduction in clone growth seen in yki^B5 mutant eye discs.

Tgi^ΔP partially suppresses the reduction in clone growth seen in yki^B5 mutant eye discs. The clones comprise ~7% of the eye disc.

(Koontz et al., 2013)

yki^B5/+ suppresses the wing disc overgrowth caused by expression of ptc^JF03223 in clones in the wing disc.

(Kagey et al., 2012)

yki^B5/+ does not suppress the reduced eye size caused by W^GMR.PG.

(Schoenherr et al., 2012)

One copy of yki^B5 suppresses the eye and head overgrowth phenotype seen in mop^sfv11 Df(3L)H99 mutant clones (generated in a minute background).

(Gilbert et al., 2011)

yki^B5/+ wings subjected to increased levels of cell death (by expression of debcl^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^en-e16E) display a lower regenerative capacity than control wings.

(Grusche et al., 2011)

yki^B5/+ partially suppresses the retinal neurodegeneration seen in ft⁸ clones.

(Napoletano et al., 2011)

A yki^B5 mutant background suppresses the overgrowth seen when tkv^{Q253D.Scer\UAS.cNc} is expressed in wing disc clones under the control of Scer\GAL4^{Scer\FRT.Act5C}. As in yki^B5 mutants alone, very few clones are recoverable.

(Oh and Irvine, 2011)

The enlarged eye phenotype seen in mosaic animals in which the eye is homozygous for gfr¹ is suppressed by yki^B5/+.

(Beam and Moberg, 2010)

The small size of homozygous yki^B5 clones in the eye is rescued by expression of ban^A.Scer\UAS under the control of Scer\GAL4^mirr-DE in the dorsal part of the eye.

(Morrison and Halder, 2010)

Expression of th^{V85M.Scer\UAS} in wing disc clones (under the control of Scer\GAL4^tub.PU) in yki^B5 mutant animals increases clone size compared to yki^B5 alone. Co-expression of dm^Scer\UAS.cZa in this background fails to rescue the growth defect of yki^B5 mutant clones, and growth rates are similar to when th^{V85M.Scer\UAS} is expressed alone in yki^B5 mutant discs.

Expression of ban^EP3622 in wing disc clones (under the control of Scer\GAL4^tub.PU) in yki^B5 mutant animals increases clone size compared to yki^B5 alone. Co-expression of dm^Scer\UAS.cZa in this background fails to rescue the growth defect of yki^B5 mutant clones, and growth rates are similar to when ban^EP3622 is expressed alone in yki^B5 mutant discs. However, despite the small size of the clones, cell and nucleolar size are increased when dm^Scer\UAS.cZa and ban^EP3622 are expressed in yki^B5 wing discs.

Expression of dm^Scer\UAS.cZa in yki^B5 wing disc clones (under the control of Scer\GAL4^tub.PU) fails to rescue the growth defect of yki^B5 mutant clones. However, despite the small size of the clones, cell and nucleolar size are increased when dm^Scer\UAS.cZa is expressed in yki^B5 wing discs.

(Neto-Silva et al., 2010)

The reduction in eye size caused by expression of sd^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF is significantly enhanced by yki^B5/+.

yki^B5/+ enhances the notched wing phenotype of sd^ETX4/Y males.

Homozygous yki^B5 clones which are also expressing vg^Scer\UAS.cKa under the control of Scer\GAL4^tub.PU are readily recovered in the wing blade.

(Wu et al., 2008)

ft⁸/ft⁴²² mutants, heterozygous for yki^B5 exhibit a size and morphology similar to those of wild-type discs, indicating suppression of the ft⁸/ft⁴²² phenotype through yki^B5.

ft⁸/ft⁴²² mutants, heterozygous for yki^B5 progress to the late pupal stage of development, with some surviving to adulthood. ft⁸ yki^B5/ft⁴²² flies display defects in the size and morphology of eyes, wings, and some bristles.

(Bennett and Harvey, 2006)

yki^B5 mutant clones in the posterior of the wing disc that express ban^EP3622 under the control of Scer\GAL4^hh-Gal4, grow to larger sizes than yki^B5 clones in the anterior of the disc. These clones are not as large as the wild-type twin spots.

(Nolo et al., 2006)

The growth-promoting effects of ft⁸ clones induced in the eye is strongly suppressed by one copy of yki^B5.

(Silva, 2006, Silva et al., 2006)

Nearly all ft⁸ yki^B5/ft^G-rv mutant animals develop into adults, although they do not hatch from the pupal case as they have some leg defects and head overgrowths. In contrast, all ft⁸/ft^G-rv mutant animals die during the early stages of pupal development and show severely overgrown imaginal disc derivatives. This indicates that yki^B5 suppresses the overgrowth phenotypes of ft⁸/ft^G-rv mutant imaginal discs.

(Willecke et al., 2006)

Xenogenetic Interactions

Statement

Reference

Expression of the caspase inhibitor BacA\p35^Scer\UAS.cHa, under the control of Scer\GAL4^Act5C.PP, in yki^B5 clones only weakly rescues the yki^B5-induced growth defects.

(Nolo et al., 2006)

Complementation and Rescue Data

Rescued by

yki^B5 is rescued by Scer\GAL4^Tub.PU/yki^{UAS.cXa.Tag:FLAG}

(Xu et al., 2018)

yki^B5 is rescued by yki^UAS.cZb/Scer\GAL4^αTub84B.PL

(Zhang et al., 2012)

yki^B5 is rescued by yki^Δ.UAS/Scer\GAL4^αTub84B.PL

(Zhang et al., 2012)

yki^B5 is rescued by yki^{UAS.cOa.Tag:V5}/Scer\GAL4^ci.PC

(Oh and Irvine, 2009)

yki^B5 is rescued by yki^{UAS.cOa.Tag:V5}/Scer\GAL4^arm.PS

(Oh and Irvine, 2009)

yki^B5 is rescued by Scer\GAL4^ci.PC/yki^{S169A.S172A.UAS.Tag:V5}

(Oh and Irvine, 2009)

yki^B5 is rescued by yki^UAS.cZb/Scer\GAL4^GMR.PF

(Zhang et al., 2009)

yki^B5 is rescued by yki^S168A.UAS/Scer\GAL4^GMR.PF

(Zhang et al., 2009)

yki^B5 is rescued by yki^{UAS.EGFP,Tag:HA}/Scer\GAL4^arm.PS

(Oh and Irvine, 2008)

yki^B5 is rescued by Scer\GAL4^ci.PC/yki^{UAS.EGFP,Tag:HA}

(Oh and Irvine, 2008)

Not rescued by

yki^B5 is not rescued by Scer\GAL4^Tub.PU/yki^{UAS.Tag:FLAG,Tag:Myr(Src64B)}

(Xu et al., 2018)

yki^B5 is not rescued by yki^{ΔNH.UAS.Tag:FLAG,Tag:Myr(Src64B)}/Scer\GAL4^Tub.PU

(Xu et al., 2018)

yki^B5 is not rescued by Scer\GAL4^arm.PS/yki^{S169A.S172A.UAS.Tag:V5}

(Oh and Irvine, 2009)

yki^B5 is not rescued by yki^{-WW.UAS.Tag:V5}/Scer\GAL4^arm.PS

(Oh and Irvine, 2009)

yki^B5 is not rescued by yki^WW12.UAS/Scer\GAL4^GMR.PF

(Zhang et al., 2009)

Comments

Expression of yki^Scer\UAS.cZb under the control of Scer\GAL4^αTub84B.PL rescues the size of yki^B5 somatic clones.

Expression of yki^Δ.Scer\UAS under the control of Scer\GAL4^αTub84B.PL rescues the size of yki^B5 somatic clones.

(Zhang et al., 2012)

Expression of yki^Scer\UAS.cZb under the control of Scer\GAL4^GMR.PF rescues the growth defect seen in yki^B5 mutant clones.

Expression of yki^{S168A.Scer\UAS} under the control of Scer\GAL4^GMR.PF rescues the growth defect seen in yki^B5 mutant clones.

Expression of yki^{WW12.Scer\UAS} under the control of Scer\GAL4^GMR.PF fails to rescue the growth defect seen in yki^B5 mutant clones.

(Zhang et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

36290

l(2)gl⁴ yki^B5/CyO

600547

PBac{yki-YFP}VK00037 yki^B5

600525

w^*; P{neoFRT}42D yki^B5/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Yki^B5

(Suijkerbuijk et al., 2016, Napoletano et al., 2011)

YkiB5

(Wang et al., 2016)

yki^5B

(Bilak et al., 2014)

yki^B5

(Mitchell et al., 2024, Sun et al., 2024, Tokamov et al., 2024, Wang et al., 2024, Zhang et al., 2024, Zhang et al., 2024, Fulford et al., 2023, Ku et al., 2023, Shi et al., 2023, Zhao et al., 2023, Crucianelli et al., 2022, Kong et al., 2022, Liu et al., 2022, Neal et al., 2022, Yang et al., 2022, Wada et al., 2021, Guo et al., 2020, Hao et al., 2020, Ma et al., 2020, Tyra et al., 2020, Ueoka et al., 2020, Venugopal et al., 2020, Guo et al., 2019, Matsui et al., 2019, McSharry and Beitel, 2019, Sarpal et al., 2019, Skouloudaki et al., 2019, Sun et al., 2019, Yee et al., 2019, Albert et al., 2018, Azuma et al., 2018, Katsukawa et al., 2018, Xu et al., 2018, Yu and Pan, 2018, Anderson et al., 2017, Hsu et al., 2017, Li et al., 2017, Becker et al., 2016, Ding et al., 2016, Liu et al., 2016, Zhou et al., 2016, Bunker et al., 2015, Dong et al., 2015, Keder et al., 2015, Li et al., 2015, Sarikaya and Extavour, 2015, Wang and Baker, 2015, Zaessinger et al., 2015, Bilak et al., 2014, Huang et al., 2014, Qing et al., 2014, Skwarek et al., 2014, Jukam et al., 2013, Jukam et al., 2013, Koontz et al., 2013, Kagey et al., 2012, Poernbacher et al., 2012, Schoenherr et al., 2012, Zhang et al., 2012, Gilbert et al., 2011, Grusche et al., 2011, Oh and Irvine, 2011, Richter et al., 2011, Sansores-Garcia et al., 2011, Baumgartner et al., 2010, Beam and Moberg, 2010, Morrison and Halder, 2010, Neto-Silva et al., 2010, Ren et al., 2010, Ziosi et al., 2010, Oh and Irvine, 2009, Oh et al., 2009, Zhang et al., 2009, Oh and Irvine, 2008, Wu et al., 2008, Dong et al., 2007, Shcherbata et al., 2007, Bennett and Harvey, 2006, Emoto et al., 2006, Nolo et al., 2006, Silva, 2006, Silva et al., 2006, Willecke et al., 2006)

yki^b5

(Parker and Struhl, 2015)

yorkie^B5

(McSharry and Beitel, 2019)

Name Synonyms

Secondary FlyBase IDs

References (88)

Report Sections

Open Close