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General Information
Symbol
Dmel\carΔ146
Species
D. melanogaster
Name
FlyBase ID
FBal0194558
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Approximate location of deletion resulting from the imprecise excision of P{lacW}carG0447. The deletion extends from the insertion site (~150 bases upstream of the car ATG through codon 584.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion that removes almost the entire car coding sequence (sequences encoding amino acid residues 1-584 out of 617 residues are removed), without disrupting neighbouring genes..

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous mushroom body gamma neuron clones show normal axon pruning.

Homozygotes do not develop beyond the second larval instar, although the second instar larvae can survive up to 6 days from the day of egg laying.

Homozygous clones in the eye lack almost all pigmentation. All photoreceptor cells are present in the mutant ommatidia and are arranged in their normal trapezoidal configuration. The rhabdomeres in the mutant ommatidia are smaller than normal (this phenotype is cell-autonomous) in 2 day old adults, and the mutant photoreceptors have an extensive accumulation of vacuoles, many of which have the double membranes typical of autophagosomes.

Homozygous clones in the eyes of 20 day old flies show extensive degeneration of retinal cells, with most cellular structures, including rhabdomeres, being barely recognisable. This phenotype is not light dependent.

2 day old flies with homozygous clones in the wing show a darkening of the wing as the first sign of degeneration. In older flies, the wings start to become frayed and end up notched.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Vps33BScer\UAS.T:Hsap\MYC under the control of Scer\GAL4tub in carΔ146 clones in the eye does not restore pigmentation in the clones and does not prevent the late degeneration seen in single mutant carΔ146 patches in the eye.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (7)