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General Information
Symbol
Dmel\bmmUAS.cGa
Species
D. melanogaster
Name
FlyBase ID
FBal0195575
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-bmm
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an embryonic bmm cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  obesity
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

lipid droplet & larval oenocyte, with Scer\GAL4Lsp2.PH

lipid droplet & larval oenocyte, with Scer\GAL4ppl.PP

Detailed Description
Statement
Reference

Expression of bmmScer\UAS.cGa using Scer\GAL4ppl.PP increases neutral lipids in oenocytes.

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4fat decreases the fat content of flies compared to controls.

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4Lsp2.PH rescues the increase in triglyceride levels and the heart defects normally caused by a high-fat diet.

Expression of bmmScer\UAS.cGa under the simultaneous control of both Scer\GAL4Scer\UAS.cHa and Scer\GAL4tin.cBa does not rescue the increase in triglyceride levels caused by a high-fat diet. However, the heart defects normally caused by a high-fat diet are rescued in these animals.

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4ppl.PP results in an accumulation of lipid droplets in the oenocytes of 92% of fed larvae (this contrasts with wild-type larvae, where oenocytes accumulate lipid droplets specifically under starvation conditions).

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4Lsp2.PH results in an accumulation of lipid droplets in the oenocytes of 100% of fed larvae.

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4fat in fed flies depletes the storage fat (measured as triacylglycerol content) of immature (less than 1 day old) and mature (6 days old) adults by 96% and 46%, respectively, compared to controls.

Fat body cells of immature adults expressing bmmScer\UAS.cGa under the control of Scer\GAL4fat have storage droplets that are reduced in number and size.

Mature adults expressing bmmScer\UAS.cGa under the control of Scer\GAL4fat show no difference in carbohydrate storage (measured as glycogen content) compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4ninaE.PT fails to rescue the neurodegeneration and electrophysiology defect seen in fh1 mutant photoreceptor clones.

Expression of bmmScer\UAS.cGa in sicilyE mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

Expression of bmmScer\UAS.cGa in Aats-metFB mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

Expression of bmmScer\UAS.cGa in MarfB mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

Neuronal expression of bmmScer\UAS.cGa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in MarfGD11094-knockdown glia.

Neuronal expression of bmmScer\UAS.cGa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in MarfGD11094-knockdown glia.

Neuronal expression of bmmScer\UAS.cGa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in Aats-metKK108492-knockdown glia.

Neuronal expression of bmmScer\UAS.cGa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in ND-42GD6220-knockdown glia.

Knockdown of Marf in neurons (MarfninaE.GD11094) and overexpression of bmmScer\UAS.cGa in glia (under the control of Scer\GAL454C) lowers lipid droplet accumulation and delays neurodegeneration.

Knockdown of ND-42 in neurons (ND-42ninaE.GD6220) and overexpression of bmmScer\UAS.cGa in glia (under the control of Scer\GAL454C) lowers lipid droplet accumulation and delays neurodegeneration.

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4fat suppresses the increase in fat content which is seen in Lsd-11 flies and the double mutant flies are leaner than flies expressing bmmScer\UAS.cGa under the control of Scer\GAL4fat in a Lsd-1[+] background.

Immature adult flies co-expressing Lsd-2Scer\UAS.cGa and bmmScer\UAS.cGa under the control of Scer\GAL4fat have storage fat levels (measured as triacylglycerol content) intermediate between control flies and flies expressing bmmScer\UAS.cGa alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4Act5C.PI almost completely rescues the lethality of embryos maternally and zygotically mutant for bmm1.

Expression of bmmScer\UAS.cGa under the control of Scer\GAL4Act5C.PI reverts the obese phenotype of bmm1 mutant flies.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
bmmScer\UAS.cGa
bmmUAS.cGa
Name Synonyms
Secondary FlyBase IDs
    References (16)