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General Information
Symbol
Dmel\EatoGD1133
Species
D. melanogaster
Name
FlyBase ID
FBal0202996
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of EatoGD1133 under the control of Scer\GAL4GR1 results in nurse cell clearance defect in mutant stage 14 egg chambers that contain persistent nurse cell nuclei, while in wild-type egg chambers all the germ-line derived nurse cells have undergone programmed cell death and been cleared by this stage. Scer\GAL4nos.UTR.T:Hsim\VP16-driven expression of EatoGD1133 does not lead to clearance defects.

Similarly, Scer\GAL4GR1>EatoGD1133 mutants exhibit defects in engulfment of nurse cells by the follicle cells during starvation-induced programmed cell death: While phase 0 and phase 1 egg chambers resemble the control, in phase 3 eggs their follicle cells show fewer engulfed Dcp-1-positive vesicles and by phase 5 the dying mutant egg chambers display severe engulfment defects and follicle cell death, leaving behind completely unengulfed germline. No obvious engulfment defects in dying egg chambers are observed if EatoGD1133 is controlled by Scer\GAL4nos.UTR.T:Hsim\VP16.

Adults expressing CG31731GD1133 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG31731GD1133
EatoGD1133
Name Synonyms
Secondary FlyBase IDs
    References (4)