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General Information
Symbol
Dmel\Pi3K92EGD11228
Species
D. melanogaster
Name
FlyBase ID
FBal0208070
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Pi3K92EGD11228 in an otherwise wild-type posterior wing disc compartment, under the control of Scer\GAL4en.PU, results in mild growth-suppressing defects.

Adults expressing Pi3K92EGD11228 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 40-50% or 50-60% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Pi3K92EGD11228 suppresses the tissue overgrowth seen upon expression of ykiScer\UAS.cHa in the eye imaginal disc.

Knockdown of Pi3K92E in Ras85DV12.Scer\UAS-dlg1GD4689 cells, through expression Pi3K92EGD11228, causes a complete suppression of neoplastic growth and even causes a near-complete absence of mutant eye cells. Only small structures, which contain few cells, remain.

Co-expression of Pi3K92EGD11228 suppresses the tissue overgrowth seen upon expression of osScer\UAS.cZa in the eye imaginal disc.

Co-expression of Pi3K92EGD11228 suppresses the tissue overgrowth seen upon expression of both ykiScer\UAS.cHa and osScer\UAS.cZa in the eye imaginal disc.

Co-expression of Pi3K92EGD11228 suppresses the tissue overgrowth seen upon expression of both ykiScer\UAS.cHa and dlg1GD4689 in the eye imaginal disc.

Co-expression of Pi3K92EGD11228 suppresses the tissue overgrowth seen upon expression of both ykiScer\UAS.cHa and Ras85DV12.Scer\UAS in the eye imaginal disc.

Co-expression of Pi3K92EGD11228 together with Ras85DV12.Scer\UAS and dlg1GD4689, under the control of Scer\GAL4en.PU, strongly reduces the size of the Ras85DV12.Scer\UAS-dlg1GD4689 tumours in the posterior wing disc compartment. There is an almost complete absence of cellular proliferation in this compartment.

Co-expression of Pi3K92EGD11228 suppresses tumour growth in Ras85DV12.Scer\UAS MARCM third instar imaginal disc clones, although this suppression is weaker than that seen upon expression of Pi3K92EGD11228 in Ras85DV12.Scer\UAS-dlg1GD4689 MARCM third instar imaginal disc clones.

Co-expression of Pi3K92EGD11228 suppresses tumour growth in dlg1GD4689 MARCM third instar imaginal disc clones, although this suppression is weaker than that seen upon expression of Pi3K92EGD11228 in Ras85DV12.Scer\UAS-dlg1GD4689 MARCM third instar imaginal disc clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Pi3K92EGD11228
Name Synonyms
Secondary FlyBase IDs
    References (9)