FlyBase Allele Report: Dmel\bmm[GD5139]

General Information

Symbol

Dmel\bmm^GD5139

Species

D. melanogaster

Name

FlyBase ID

FBal0209157

Feature type

allele

Associated gene

Dmel\bmm

Associated Insertion(s)

Carried in Construct

P{GD5139}

Also Known As

UAS-bmm^RNAi, UAS-BMM-RNAi, Bmm RNAi

Key Links

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Dickson et al., 2007.7.18)

in vitro construct - regulatory fusion

(Dickson et al., 2007.7.18)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{GD5139}

Cytology

Nature of the lesion

Statement

Reference

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

bmm

Associated Sequence Features

dsRNA-GD5139

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage | female, with Scer\GAL4^da.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^C587

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^da.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^elav.PU

(Wat et al., 2020)

decreased memory | adult stage | calorie restriction conditional, with Scer\GAL4^GMR54H02

(Silva et al., 2022)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

chaeta | increased number, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Adults expressing bmm^GD5139 for 2 days under the combined control of Scer\GAL4^GMR54H02 and Gal80[ts] (for temporal control of expression) exhibit decreased associative olfactory memory under starvation conditions, but not when fed.

(Silva et al., 2022)

Expression of bmm^GD5139 under the control of Scer\GAL4^da.PU leads to an increase in starvation resistance in both males and females while its expression under the control of Scer\GAL4^C587 or Scer\GAL4^elav.PU leads to an increase in starvation resistance only in males.

(Wat et al., 2020)

Expression of bmm^GD5139 under the control of Scer\GAL4^sal.BO (in combination with a Dicer-2 transgene to enhance RNAi efficiency) does not result in larval lethality at the L2/L3 transition.

(Wicker-Thomas et al., 2015)

Expression of bmm^GD5139 in enterocytes under the control of Scer\GAL4^{Myo31DF-NP0001} has no effect on larval hemolymph diacylglycerol (DAG) levels.

(Palm et al., 2012)

Adults expressing bmm^GD5139 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in extra bristles on the notum in 0% or 10-20% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development