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General Information
Symbol
Dmel\Cul1GD9650
Species
D. melanogaster
Name
FlyBase ID
FBal0209934
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adults expressing Cul1GD9650 under the control of Scer\GAL4GMR.PU do not present any obvious eye defects.

Scer\GAL4sd.PU-mediated expression of Cul1GD9650 results in rudimentary wings showing morphological features of the notum.

Scer\GAL4sd.PU-mediated expression of Cul1GD9650 induces cell death in wing discs.

Expression of lin19GD9650 under the control of two copies of Scer\GAL4ppk.PG produces severe dendrite pruning defects in ddaC neurons at 16 hours after puparium formation. No difference is seen at the white prepupal stage.

Flies expressing lin19GD9650 under the control of Scer\GAL4GMR.PU have a slight rough eye phenotype.

Adults expressing Cul1GD9650 under the control of the cardioblast-specific Scer\GAL4tin.CΔ4 driver can show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies, depending on the particular P{GD9650} insertion line used.

Adults expressing Cul1GD9650 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies, early pupal lethality or late larval lethality.

Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

Expression under the control of Scer\GAL4pnr-MD237 may result in lethality, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
NOT Enhancer of
Other
Phenotype Manifest In
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Enhancer of
NOT Enhancer of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Scer\GAL4sd.PU-mediated expression of both Cul1GD9650 and RYBPdsRNA.Scer\UAS.cGa results in flies completely lacking wing tissue.

Expression of ciCe-2.Scer\UAS.T:Ivir\HA1 does not suppress the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of MicalN-ter.Scer\UAS does not suppress the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of sggS9A.Scer\UAS does not suppress the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of InRK1409A.Scer\UAS dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of NECN.Scer\UAS.cGa does not suppress the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation. No difference is seen in white prepupae.

Expression of PtenScer\UAS.cHa dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of Tsc1Scer\UAS.cPa and gigScer\UAS.cTa suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of TorTED.Scer\UAS suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of ThorT37A.T46A.Scer\UAS dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of S6kKQ.Scer\UAS dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of Akt1HM04007 dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Expression of Akt1HMS00007 dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

Xenogenetic Interactions
Statement
Reference

The eye defects induced by the expression of Hsap\ATXN3tr.Q78.UAS.Tag:HA under the control of Scer\GAL4GMR.PU are aggravated by the co-expression of either Cul1GD9650 or FipoQNIG.2010R to the point of even leading to necrotic scars.

Adults co-expressing Hsap\ATXN3tr.Q27.UAS.Tag:HA and Cul1GD9650 under the control of Scer\GAL4GMR.PU do not present any obvious eye defects.

Adults co-expressing Hsap\ATXN3fl.Q84.UAS.Tag:MYC and Cul1GD9650 under the control of Scer\GAL4GMR.PU display mild eye depigmentation; this phenotype is not enhanced by the additional expression of FipoQNIG.2010R.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Cul1GD9650
lin19GD9650
Name Synonyms
Secondary FlyBase IDs
    References (9)