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General Information
Symbol
Dmel\Sox102FJF02118
Species
D. melanogaster
Name
FlyBase ID
FBal0220607
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Sox102F-RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Sox102FJF02118 results in: microchaetae morphology and distribution defects including misorientation, accumulation of upper dorsal and loss of dorsal centre microchaetae (with the Scer\GAL4pnr.PU driver), courtship behavior defects, reduced brain size and brain tissue degeneration (with Scer\GAL4insc.PU) in adults as well as dendritic arbor morphology defects (reduced dendrite length, arbor surface area and its branching complexity) in dendritic arborizing neuron of third instar larvae (with Scer\GAL4ppk.PU), impaired larval crawling as well as adult climbing abilities along with reduced number of boutons at the larval neuromuscular junctions (with Scer\GAL4Toll-6-D42) and compromised larval olfactory perception as assessed by fructose preference assay (with the Scer\GAL4[Tab2-201Y] driver).

Flies expressing Sox102FJF02118 in the heart under the control of Scer\GAL4how-24B appear normal at eclosion. 30 day old flies exhibit cardiac hypertrophy, a decrease in size of the heart chamber and a decrease in heart rate and wall velocities compared to controls. This is accompanied by disrupted myofibril structure.

Expression of Sox102FJF02118 in the wing under the control of Scer\GAL4sd-SG29.1 results in a significant increase in the L2, L3 and wing marginal veins; in particular extra veins are formed in the distal part of L3.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Sox102FJF02118
Name Synonyms
Secondary FlyBase IDs
    References (6)