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General Information
Symbol
Dmel\vtdγ26-6
Species
D. melanogaster
Name
FlyBase ID
FBal0221045
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G27146884A

    Reported nucleotide change:

    G?A

    Comment:

    Mutation in the splice donor at the end of exon 5.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Mutation in the splice donor site at the 3' end of exon 5, resulting in a premature stop codon.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    In embryos derived from vtdγ26-6 females and undergoing mitosis 13, there is an increase in the number of nuclei showing the loose alignment of chromosomes seen at the metaphase to anaphase transition, and the chromosomes appear to be less condensed than normal. No mitotic abnormalities are seen in these embryos before mitosis 11, and the embryos subsequently achieve normal metaphase figures with proper condensation and alignment.

    Imaginal discs are not evident in vtd80Fh-35/vtdγ26-6 third instar larvae.

    Metaphase chromosome spreads of vtd80Fh-35/vtdγ26-6 third larval instar neuroblasts consist of individual sister chromatids that are not conjoined at the centromere. In addition, the chromosome complements are often aneuploid.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference

    vtdγ26-6/vtd[+] is an enhancer of visible phenotype of Nspl-1

    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    vtdγ26-6/vtd[+] is an enhancer of eye phenotype of Nspl-1

    vtdγ26-6/vtd[+] is an enhancer of scutellar bristle phenotype of Nspl-1

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The lack of scutellar bristles seen in Nspl-1 flies is enhanced by vtdγ26-6/+.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (2)