FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\vtdγ26-6
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General Information
Symbol
Dmel\vtdγ26-6
Species
D. melanogaster
Name
FlyBase ID
FBal0221045
Feature type
allele
Associated gene
Dmel\vtd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Mutation in the splice donor site at the 3' end of exon 5, resulting in a premature stop codon.

    (Hallson et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:27,146,884..27,146,884 [+]
    Nucleotide change:

    G27146884A

    Reported nucleotide change:

    G?A

    Comment:

    Mutation in the splice donor at the end of exon 5.

    (Hallson et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In embryos derived from vtdγ26-6 females and undergoing mitosis 13, there is an increase in the number of nuclei showing the loose alignment of chromosomes seen at the metaphase to anaphase transition, and the chromosomes appear to be less condensed than normal. No mitotic abnormalities are seen in these embryos before mitosis 11, and the embryos subsequently achieve normal metaphase figures with proper condensation and alignment.

        Imaginal discs are not evident in vtd80Fh-35/vtdγ26-6 third instar larvae.

        Metaphase chromosome spreads of vtd80Fh-35/vtdγ26-6 third larval instar neuroblasts consist of individual sister chromatids that are not conjoined at the centromere. In addition, the chromosome complements are often aneuploid.

        (Hallson et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        vtdγ26-6/vtd[+] is an enhancer of visible phenotype of Nspl-1

        (Schaaf et al., 2009)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        vtdγ26-6/vtd[+] is an enhancer of eye phenotype of Nspl-1

        (Schaaf et al., 2009)

        vtdγ26-6/vtd[+] is an enhancer of scutellar bristle phenotype of Nspl-1

        (Schaaf et al., 2009)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The lack of scutellar bristles seen in Nspl-1 flies is enhanced by vtdγ26-6/+.

        (Schaaf et al., 2009)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        vtdγ26-6
        (Schaaf et al., 2009, Hallson et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)