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General Information
Symbol
Dmel\Max1
Species
D. melanogaster
Name
FlyBase ID
FBal0230159
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

An 1804 bp deletion resulting from the imprecise excision of P{EPgy2}Mettl5EY02775 extending from nt 19255898 to nt 19257703 of AE014296.4. Deletion affects both Max and Mettl5.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a 1804bp deletion extending from nucleotide 19255898 to nucleotide 19257703 (coordinates according to GenBank accession AE014296). The deletion removes the entire Max open reading frame. The deletion also disrupts the neighbouring CG9666 gene.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The survival rate and growth of Max1 larvae is not reduced if the animals are also expressing MaxdsRNA.Scer\UAS.IR under the control of Scer\GAL4Act5C.PI.

Expression of one copy of MaxdsRNA.Scer\UAS.IR under the control of Scer\GAL4Act5C.PI results in complete lethality at the pupal stage in the presence of Max1.

Eyes largely consisting of homozygous clones develop and grow as well as control eyes.

Bristles lacking Max1 function (induced as a somatic clone) are severely stunted in their growth compared to controls.

Homozygous clones in the fat body result in fat body cells that are only moderately reduced in overall size and that have nuclei that are only moderately reduced in size. These cells are often indistinguishable from surrounding wild-type cells.

Homozygotes survive embryogenesis and hatch at the same proportions as controls. Most homozygotes survive until the pupal stages, although homozygous larvae show some reduction in viability compared to controls. 42% of homozygous pupae undergo metamorphosis, becoming morphologically normal pharate adults, but these animals never eclose.

Homozygotes are smaller than controls at the larval, pupal and pharate adult stages.

Homozygotes show a normal rate of development up to the molt from second to third instar, but homozygous third instar larvae pupariate only between days 8 and 10 after egg deposition (wild-type animals pupariate at day 5 after egg deposition).

Homozygous third instar larvae have fewer teeth on their mouth hooks than normal, and occasionally the tips of these mouth hooks are forked. Most pupae fail to evert their anterior spiracles.

Max1 larval fat body and salivary gland cells grow markedly between days 5 and 8 after egg deposition and reach near wild-type sizes.

Homozygous 72 hour old clones in the imaginal discs of wandering third instar larvae are not significantly different in size from their wild-type twin spots and are made up of normally sized cells.

Homozygous clones in the eye generated using the ey-FLP system can occupy a large fraction of the eye, as occurs with wild-type clones generated using this method.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Max1 is a suppressor | partially of lethal | recessive phenotype of Myc4

Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

dmP0/Y ; Max1/+ flies take slightly longer for their development than controls.

dm4 Max1 and dm4 Mnt1 Max1 larvae grow better and survive to a greater extent than dm4 single mutant larvae.

Clones in the wing disc expressing wild-type levels of dm in a Max1 background and in which the surrounding wing disc cells are expressing dmαTub84B.PBb are smaller than genetically identical clones in the wing disc that are in a Max1 background and in which the surrounding wing disc cells express normal levels of dm.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (2)