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General Information
S. cerevisiae
FlyBase ID
Feature type
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
C161-GAL4, C161, smid-GAL4
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
Additional Notes
Associated Sequence Data
DNA sequence
Protein sequence
Progenitor genotype
Nature of the lesion
Insertion components
Product class / Tool use(s)
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Tissue/Position (including subcellular localization)
small field neuron

Comment: expression starts 32 hr APF

sensory neuron of tibia | subset

Comment: Located at the tibial-tarsal joint

sensory neuron of metatarsus | subset

Comment: Located at the distal joint.

sensory neuron of tarsal segment 2 | subset

Comment: Located at the distal joint.

sensory neuron of tarsal segment 3 | subset

Comment: Located at the distal joint.

sensory neuron of tarsal segment 4 | subset

Comment: Located at the distal joint.

sensory neuron of central nervous system | subset

Comment: Neuron is probably mechanosensory

Additional Information

Drives expression in sensory neurons. Also drives expression in small field neurons associated with the ellipsoid body, protocerebral bridge, and nodulus.

Scer\GAL4smid-C161 drives expression in larval multidendritic neurons ldaB, ddaC and ddaE.

Third instar expression is observed in vbd- and dbd-neurons, one lateral chordotonal organ, multidendritic neurons, and most likely to the vpda-neurons. See diagram in Fig 3C of FBrf0160715.

Adult expression is observed in small field neurons that connect the ellipsoid body with the nodulus and the protocerebral bridge.

Reporter gene expression was examined in early to mid larval stages. Expression is observed in sensory neurons and neuroblasts in the cephalic and thoracic neuromeres of the CNS and in imaginal discs. No expression was observed in embryos.

Expression of Scer\GAL4smid-C161 is found in internal sensory neurons associates with the trochanter/femur articulation, an internal receptor associated with the tibial/tarsal joint and internal receptors associated with each of the tarsal segment. Expression of Scer\GAL4smid-C161 is also seen in neurons at the articulations of the more distal tibial and tarsal segments of the leg, which are thought to be stretch receptors. Expression of Scer\GAL4smid-C161 in the hair plates of the trochanter and the coxa is restricted to a small group of cell bodies at the base of the external sensilla that extend neurites into the sockets of the sensilla. Expression of Scer\GAL4smid-C161 is seen in approximately five sensilla of a cluster of eleven campaniform sensilla (believed to be the FeCS11) located on the ventral surface of the proximal femur. On the haltere, expression of Scer\GAL4smid-C161 is detected in two large groups of cells associated with a cluster of sensilla on the scabellum and pediculus. Furthermore, expression is detected in two clusters of scolopale cells in the scabellum. Abdominal expression of Scer\GAL4smid-C161 is seen, in each segment, in bilaterally symmetrical sensory structures: a pair of small neurons on either side of the midline that extend along the lateral muscles; a single neuron attached to one of the dorsal muscles; a midbody positioned neuron that extends processes both ventrally to the CNS and dorsally to arborise on the dorsal alar muscle. CNS expression is seen in the nerves originating from the leg and the haltere, nerves from the abdominal segments, and axons from the prothoracic stretch receptor which enter the CNS within the leg nerve.

Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Modifiers Based on Experimental Evidence ( 0 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
Disease-implicated variant(s)
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

prothoracic femoral chordotonal organ & axon, with Avic\GFPUAS.S65T.I167T.Tag:MT(btau)

Detailed Description

Inhibition of neural activity in Scer\GAL4smid-C161-expressing neurons (in which expression is suppressed in the ventral nerve cord using Scer\GAL80tsh-GAL80) does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

External Data
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Xenogenetic Interactions
Complementation and Rescue Data
Images (0)
Stocks (1)
Notes on Origin
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
  • FBal0052390
  • FBal0181626
References (43)