Co-expression of cindr^{dsRNA.Scer\UAS} and cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in defects in the position and shape of interommatidial precursor cells, primary primary pigment cells and cone cells.

Co-expression of cindr^{dsRNA.PC.PD.Scer\UAS} and cindr^{dsRNA.Scer\UAS} under the control of Scer\GAL4^GR1 results in a significant increase in the number of binucleate follicle cells compared to control egg chambers. The increase in binucleate follicle cells is accompanied by a significant decrease in the average number of follicle cell intercellular bridges per nucleus.

Expression of cindr^{dsRNA.Scer\UAS} under the control of Scer\GAL4³⁰⁶ results in a weak border cell migration defect in the egg chamber.

Ubiquitous expression of cindr^{dsRNA.Scer\UAS} under the control of Scer\GAL4^tub leads to embryonic and early larval lethality.

Expression of cindr^{dsRNA.Scer\UAS} and cindr^{dsRNA.PC.PD.Scer\UAS} in the eye for at least 24 hours (under the control of Scer\GAL4^GMR.PF) does not generate any developmental defects.

Initial recruitment of 1[o] cells in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS}, cindr^{dsRNA.Scer\UAS} eyes commences normally and many, though not all, fledgling 1[o] cells successfully encircle a central cone cell quartet. However, these emerging 1[o] cells commonly fail to maintain their niches: 1[o] cells often lose contact with their partners, a loss typically coupled with dissolution of their shared junction. As a result, one proto-1[o] cell is often replaced by another cell to generate a new 1[o] cell. Remarkably, this instability of the 1[o]-1[o] interface continues throughout the stages of interommatidial precursor cell patterning hours after 1[o] cells have normally completed their movements.

Expression of cindr^{dsRNA.Scer\UAS} in the pupal eye (under the control of Scer\GAL4^GMR.PF) results in misplacement of cells, misorientation of pattern elements within the ommatidial field, and a variable number of pigment cells. An additional one to two pigment cells surround approximately 16% of Scer\GAL4^GMR.PF>cindr^{dsRNA.Scer\UAS} ommatidia. Patterning of the interommatidial precursor cells is delayed or lost in these flies.

Small clonal patches of 1[o] cells expressing cindr^{dsRNA.PC.PD.Scer\UAS} and cindr^{dsRNA.Scer\UAS} under the control of Scer\GAL4^{Scer\FRT.Act5C} are consistently smaller than their wild-type neighbours. Paired cindr^{dsRNA.PC.PD.Scer\UAS} 1[o] cells frequently retract, permitting a neighbouring wild-type interommatidial precursor cell direct contact with the central cone cells and often leads to an ectopic third 1[o] cell.

Strongly reducing cindr activity (in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS}, cindr^{dsRNA.Scer\UAS} mutants) has a marked effect on F-actin during interommatidial precursor cell patterning: at 28 hours APF, the density of F-actin fibrils and spikes filling the cytoplasm of interommatidial precursor cells is markedly increased. At later stages of patterning, a more dense and disorganized cytoskeletal network is observed in interommatidial precursor cells and the radiating arrangement of actin fibrils in 1[o] cells absent at 41 hours APF. Within cone cells, F-actin levels are mildly elevated at 28 hours APF, and distinct F-actin spikes fail to radiate from cell membranes.

Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}, cindr^RNAi.UAS has interommatidial precursor cell phenotype, enhanceable by Cbl^F165/Cbl[+]

Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}, cindr^RNAi.UAS has primary pigment cell phenotype, enhanceable by Cbl^F165/Cbl[+]

Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}, cindr^RNAi.UAS has cone cell phenotype, enhanceable by Cbl^F165/Cbl[+]