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General Information
D. melanogaster
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Feature type
Associated gene
Associated Insertion(s)
Carried in Construct
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Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
Additional Notes
Associated Sequence Data
DNA sequence
Protein sequence
Progenitor genotype
Carried in construct
Nature of the lesion

UAS regulatory sequences drive expression of an inverted repeat (IR) that targets all known (3) isoforms of cindr.

Allele components
Product class / Tool use(s)
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Expression Data
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Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description

Co-expression of cindrdsRNA.Scer\UAS and cindrdsRNA.PC.PD.Scer\UAS under the control of Scer\GAL4GMR.PF results in defects in the position and shape of interommatidial precursor cells, primary primary pigment cells and cone cells.

Co-expression of cindrdsRNA.PC.PD.Scer\UAS and cindrdsRNA.Scer\UAS under the control of Scer\GAL4GR1 results in a significant increase in the number of binucleate follicle cells compared to control egg chambers. The increase in binucleate follicle cells is accompanied by a significant decrease in the average number of follicle cell intercellular bridges per nucleus.

Expression of cindrdsRNA.Scer\UAS under the control of Scer\GAL4306 results in a weak border cell migration defect in the egg chamber.

Ubiquitous expression of cindrdsRNA.Scer\UAS under the control of Scer\GAL4tub leads to embryonic and early larval lethality.

Expression of cindrdsRNA.Scer\UAS and cindrdsRNA.PC.PD.Scer\UAS in the eye for at least 24 hours (under the control of Scer\GAL4GMR.PF) does not generate any developmental defects.

Initial recruitment of 1[o] cells in Scer\GAL4GMR.PF>cindrdsRNA.PC.PD.Scer\UAS, cindrdsRNA.Scer\UAS eyes commences normally and many, though not all, fledgling 1[o] cells successfully encircle a central cone cell quartet. However, these emerging 1[o] cells commonly fail to maintain their niches: 1[o] cells often lose contact with their partners, a loss typically coupled with dissolution of their shared junction. As a result, one proto-1[o] cell is often replaced by another cell to generate a new 1[o] cell. Remarkably, this instability of the 1[o]-1[o] interface continues throughout the stages of interommatidial precursor cell patterning hours after 1[o] cells have normally completed their movements.

Expression of cindrdsRNA.Scer\UAS in the pupal eye (under the control of Scer\GAL4GMR.PF) results in misplacement of cells, misorientation of pattern elements within the ommatidial field, and a variable number of pigment cells. An additional one to two pigment cells surround approximately 16% of Scer\GAL4GMR.PF>cindrdsRNA.Scer\UAS ommatidia. Patterning of the interommatidial precursor cells is delayed or lost in these flies.

Small clonal patches of 1[o] cells expressing cindrdsRNA.PC.PD.Scer\UAS and cindrdsRNA.Scer\UAS under the control of Scer\GAL4Scer\FRT.Act5C are consistently smaller than their wild-type neighbours. Paired cindrdsRNA.PC.PD.Scer\UAS 1[o] cells frequently retract, permitting a neighbouring wild-type interommatidial precursor cell direct contact with the central cone cells and often leads to an ectopic third 1[o] cell.

Strongly reducing cindr activity (in Scer\GAL4GMR.PF>cindrdsRNA.PC.PD.Scer\UAS, cindrdsRNA.Scer\UAS mutants) has a marked effect on F-actin during interommatidial precursor cell patterning: at 28 hours APF, the density of F-actin fibrils and spikes filling the cytoplasm of interommatidial precursor cells is markedly increased. At later stages of patterning, a more dense and disorganized cytoskeletal network is observed in interommatidial precursor cells and the radiating arrangement of actin fibrils in 1[o] cells absent at 41 hours APF. Within cone cells, F-actin levels are mildly elevated at 28 hours APF, and distinct F-actin spikes fail to radiate from cell membranes.

External Data
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Additional Comments
Genetic Interactions

CblF165/+ enhances the mis-patterning of interommatidial precursor cells, primary primary pigment cells and cone cells caused by co-expression of cindrdsRNA.Scer\UAS and cindrdsRNA.PC.PD.Scer\UAS under the control of Scer\GAL4GMR.PF.

Expression of cindrdsRNA.Scer\UAS under the control of Scer\GAL4306 in a mimnull background restores the ability of border cells in the egg chamber to migrate.

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Synonyms and Secondary IDs (2)
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