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General Information
Symbol
Dmel\pog1
Species
D. melanogaster
Name
FlyBase ID
FBal0244169
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos derived from homozygous pog1 germ line clones show severe defects in germ band extension, but no defects in ventral furrow formation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

The Mon1156 mutation was identified as an amber mutation within the Mon1 coding sequence on the chromosome carrying the pog1 mutant allele. Lethality of the chromosome in transheterozygous combination with the Mon1Δ181 mutant can be rescued by overexpression of Mon1, confirming that Mon1 gene function is disrupted by the Mon1156 mutation. However, the homozygous lethality of this chromosome cannot be rescued by overexpression of Mon1, indicating that the chromosome also carries a second site mutation that contributes to the lethality of the chromosome. FlyBase curator comment: it is not yet clear whether the 'poor gastrulation' phenotype for which the unmapped pog1 mutation was named is due to disrupted function of the Mon1 gene (caused by the Mon1156 mutation) and/or due to the second site mutation on the chromosome, thus the pog1 allele and parent pog gene have been kept as separate entities in FlyBase from Mon1156 and Mon1 until more information becomes available [date: 200812].

Comments
Comments

The pog1 mutation was initially incorrectly ascribed to 'CG31660'/'smog' (in FBrf0208913) - FBrf0231092 shows that pog1 complements the smognull deletion of CG31660.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)