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General Information
Symbol
Dmel\Pex107
Species
D. melanogaster
Name
FlyBase ID
FBal0245129
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EPgy2}CG12099EY23523 generates a deletion in pex10 that removed part of exon 1 and exon 2 of pex10.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

pex107 mutants exhibit reduced female fertility and male sterility. pex107 mutant testes contain many spermatocytes and some 'cotton ball'-like spheres but completely lack elongated spermatid bundles and mature sperm. The mutant testes appear much thinner and longer on the seventh day after eclosion than they do immediately after eclosion.

pex107 mutants display growth defects, with mutants exhibiting a 2-day delay in eclosion.

pex107 mutant testes do not contain hardly any normal mature spermatocytes. Instead, only a few fused spermatocytes with condensed chromosomes are found. In addition, there are more spermatocytes in pex107 mutants than wild-type. In pex1010 mutants, cysts of 16 spermatocytes without cell-cell boundaries and with large round nuclei are present. This suggests that the spermatocyte growth stage is defective. The majority of spermatocytes do not mature, and some are fused. the fused spermatocytes are able to continue develop but exhibit profound defects in spermatid differentiation. Only a few round spermatids are found compared with wild-type and they often exhibit four or more nuclei associated with a single enlarged mitochondrial derivative, indicating a failure of cytokinesis during meiotic division. Chromosome segregation appears unaffected. Unlike wild-type testes, which have very long spermatid bundles, the few spermatids in pex107 mutants, presumably from a cyst, form 'cotton ball'-like spheres. Thus pex107 mutant spermatids can initiate the extension of sperm tails, but this process is abnormal.

pex107 mutant spermatocytes go through G1/S phase normally but do not reach the G2/M transition.

Peroxisomal membrane protein targeting and peroxisomal structures appear quite normal in pex107 mutants.

Growing pex107 mutants on medium to which 2.5% VLCFA has been added results in a significant enhancement of the pex107 testis phenotype compared to pex107 flies grown on non-supplemented food. In contrast, adding 2.5% LCFA to the food does not enhance the testis phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

bondZ5274, pex10[+]/Pex107 has male sterile phenotype, suppressible by Pex2HP35039/CG7081[+]

bondZ5274, pex10[+]/Pex107 has abnormal cytokinesis phenotype, suppressible by Pex2HP35039/CG7081[+]

Suppressor of
Statement
Reference

pex10[+]/Pex107 is a suppressor of male sterile phenotype of bondZ5274, Pex2HP35039/CG7081[+]

pex10[+]/Pex107 is a suppressor of abnormal cytokinesis phenotype of bondZ5274, Pex2HP35039/CG7081[+]

pex10[+]/Pex107 is a suppressor | partially of male sterile phenotype of bondZ5274

pex10[+]/Pex107 is a suppressor | partially of abnormal cytokinesis phenotype of bondZ5274

Phenotype Manifest In
NOT suppressed by
Statement
Reference

Pex107 has spermatid phenotype, non-suppressible by Scer\GAL4nos.PG/Pex2UAS.cCa

Pex107 has testis phenotype, non-suppressible by Scer\GAL4nos.PG/Pex2UAS.cCa

Pex107 has spermatid phenotype, non-suppressible by Pex2UAS.cCa/Scer\GAL4Hsp83.PA

Pex107 has testis phenotype, non-suppressible by Pex2UAS.cCa/Scer\GAL4Hsp83.PA

Pex107 has testis phenotype, non-suppressible by Scer\GAL4ptc-559.1/Pex2UAS.cCa

Pex107 has testis phenotype, non-suppressible by Scer\GAL4nos.PG/Pex2UAS.mCherry

Additional Comments
Genetic Interactions
Statement
Reference

Expression of pex2Scer\UAS.cCa under the control of Scer\GAL4nos.PG, Scer\GAL4Hsp83.PA or Scer\GAL4ptc-559.1 fails to suppress the male sterility and spermatocyte developmental phenotypes associated with pex107 mutants.

Expression of pex2Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4nos.PG, Scer\GAL4Hsp83.PA or Scer\GAL4ptc-559.1 fails to suppress the male sterility and spermatocyte developmental phenotypes associated with pex107 mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Pex107
Name Synonyms
Secondary FlyBase IDs
    References (1)