cathD1 homozygotes or heterozygotes do not exhibit a significant increase in the proportion of hyperplastic testes, as compared to controls.
cathD1 mutant males exhibit ~60% less spermatogonial cyst death compared to controls.
cathD1 homozygous adults exhibit an apparently normal lifespan and their brains exhibit apparently normal levels of apoptosis (as visualized with TUNEL), DNA replication (as visualized with PCNA) and vacuolization, as compared to controls.
33% of cathD1 stage 14 egg chambers show persisting nurse cell nuclei, compared to 7% in controls. 2% of egg chambers display a dumpless phenotype where nurse cell cytoplasm has not been transferred to the oocyte.
Forty-five day old cathD1 mutant retina exhibit slight vacuolar changes (due to eye degeneration) compared to wild-type controls.
Significant numbers of apoptotic nuclei are observed in the brains of 45-day old cathD1/Df(2R)CA53 or cathD1 homozygous flies, compared to rare apoptotic nuclei observed in control brains. A normal number of apoptotic cells are observed in 1, 15 and 30-day old mutant flies.